TheLiverDoc Profile picture
Dec 7, 2022 6 tweets 3 min read Read on X
1/6
2022 is coming to an end, glad to share 15th publication from our department for the year

Severe alcohol hepatitis has no approved treatment
Recommended treatment is steroids

Some patients dont respond to steroids
They are offered other options...
#livertwitter #medtwitter
2/6
...such as Pentoxifylline.

But even Pentoxifylline therapy does not improve survival in patients with severe alcohol hepatitis

In this study, we looked at how intestinal bacteria affect patients on Pentoxifylline therapy

and

compared them with a group on stool transplant
3/6
Very interestingly, we found that more dangerous groups of bacteria increased in patients on Pentoxifylline therapy

while those receiving healthy donor stool transplant developed good bacteria that reduced liver disease

Central influencer bacteria after Pentoxifylline..
4/6
..remained pathogenic (disease producing), while after stool transplant, the main influencer bacterial groups changed towards the good 'gut-health' promoting species

Bad guys: Bacillus, Eggerthella, Aerococcaceae
Good guys: Bifidobacterium, Bacteroides, Citrobacter
5/6
Study doesn't conclusively show cause-effect relationships & a prospective trial is needed - but bacterial changes were striking and methodology was strong for us to have a good idea about treatment related bacteria changes in intestine.

Full paper: academic.oup.com/gastro/article…
6/6
In case you missed a very cool and simple to understand report on how stool transplants are being investigated for treatment of liver diseases, please check out from @ThePrintIndia featuring our previous works
theprint.in/health/poop-ha…

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More from @theliverdr

Jul 27
We recently published our independent analysis of Homeopathic practitioner commonly prescribed and popular over-the-counter 134 Homeopathy products marketed and sold as "medicine."

The Placebo Project: An observational study and comprehensive analysis of 134 commonly prescribed homeopathic remedies in India uncovers potential for hepatotoxicity: journals.lww.com/md-journal/ful…

Here is our plain language and visual abstract summary of what these Homeopathy products are and what we found in them.

1/3 - Classical (Diluted) Homeopathy ProductsImage
2/3 - Homeopathic Mother Tinctures Image
3/3 - Homeopathic Proprietary Products Image
Read 4 tweets
Jul 19
Ok. Let's properly study Ayurveda.
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Read 16 tweets
Jul 17
Dear friends, the most important update from our Citizens Protein Project 2. Please read and understand. This is on "amino spiking," a fraudulent practice... 1/8 Image
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Read 8 tweets
Jul 16
1/4: AN UPDATE: The Citizens Protein Project 2 Image
2/4: Image
3/4: Image
Read 4 tweets
Jul 13
Here we go. Results of Citizens Protein Project 2. Please read, share max. We have to bring in change. Thank you for your contributions. Huge thanks to @arifhussaintm who led clinical research division on behalf of Mission for Ethics and Science in Healthcare to do this...1/15Image
2/15 Image
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Read 15 tweets
Jul 10
A new patient who came to me said he was promised a liver detox to 'improve functions' of cirrhosis liver. He spent ~ 200,000 INR (2333 USD) for 20 days of Ayurvedic therapy. And luckily escaped severe complications.

So, here is a...Public Service Announcement
1/17 Image
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Read 17 tweets

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