1/6
2022 is coming to an end, glad to share 15th publication from our department for the year
Severe alcohol hepatitis has no approved treatment
Recommended treatment is steroids
Some patients dont respond to steroids
They are offered other options... #livertwitter#medtwitter
2/6
...such as Pentoxifylline.
But even Pentoxifylline therapy does not improve survival in patients with severe alcohol hepatitis
In this study, we looked at how intestinal bacteria affect patients on Pentoxifylline therapy
and
compared them with a group on stool transplant
3/6
Very interestingly, we found that more dangerous groups of bacteria increased in patients on Pentoxifylline therapy
while those receiving healthy donor stool transplant developed good bacteria that reduced liver disease
Central influencer bacteria after Pentoxifylline..
4/6
..remained pathogenic (disease producing), while after stool transplant, the main influencer bacterial groups changed towards the good 'gut-health' promoting species
Bad guys: Bacillus, Eggerthella, Aerococcaceae
Good guys: Bifidobacterium, Bacteroides, Citrobacter
5/6
Study doesn't conclusively show cause-effect relationships & a prospective trial is needed - but bacterial changes were striking and methodology was strong for us to have a good idea about treatment related bacteria changes in intestine.
6/6
In case you missed a very cool and simple to understand report on how stool transplants are being investigated for treatment of liver diseases, please check out from @ThePrintIndia featuring our previous works theprint.in/health/poop-ha…
• • •
Missing some Tweet in this thread? You can try to
force a refresh
The best treatment for fatty liver disease is to prevent it by improving your cardiometabolic health. Here is a small list of tasks that I advise my patients to undergo to assess their "fitness" before I prescribe exercise for treating fatty liver.
1/7
Ayurvedic companies with huge bank accounts spend money on shoddy research and publish in open access journals to white wash ancient pseudoscience as scientific evidence. Here is how.
1/15