Thread by @EurekaHealthApp

#MicroClots are showing a lot of promise as a key piece of the #LongCovid puzzle (#TeamClots).

#nattokinase and #serrapeptase are supplements help break them down. They've provided relief to many, and are available today.

How do they work, and how do you get started? 🧵

1/ How do they work?

@resiapretorius's work identifying #MicroClots in #LongCovid patients was groundbreaking. These clots are different from stroke-causing clots, but could still be causing major issues.

nature.com/articles/d4158…

Covid spike protein can cause blood clots, and there's evidence that virus persists in the body for months after infection, which could contribute to ongoing clotting.

Micro-clots could be gumming up capillaries and reducing oxygenation of tissues, leading to brain fog, fatigue, PEM, shortness of breath, and others.

Treatments addressing this pathway seem to be working:
- Anticoagulant "Triple Therapy" has shown initial promise, though more trials are needed
- Hyperbaric oxygen therapy appears to be helping some
- Nattokinase and Serrapeptase appear to be helping many

What is Nattokinase (NK)?

Natto is a fermented soybean dish common in East Asia. It's associated with better circulation and cardiovascular health.

NK is enzyme that breaks down fibrin, which is present in blood clots. It also appears to break down spike protein.

What is Serrapeptase (SP)?

It's an enzyme found in bacteria in silkworms, and it digests proteins, including fibrin. It has anti-inflammatory and anti-viral properties, it could help break down biofilm-based viral reservoirs, and it could even help reduce histamine release.

NK and SP have complementary mechanisms of action, and seem to provide the most benefit when taken together.

You'll often see Lumbrokinase (LK) mentioned too - it's similar to NK, but a bit less common.

In one of @organichemusic's essential surveys, it was reported that NK (or LK) has >50% efficacy, and is in the top 5 most beneficial treatments.

https://twitter.com/organichemusic/status/1592852928267956225

2/ How to get started

This is not medical advice, check with your doctor before making any treatment changes!

It's a good idea to start with a small dose to assess tolerability, and slowly increase from there. People have seen benefit with 2-4000 FU per day of natto and 40-160000 SPU of serrapeptase, though some are trying higher doses.

Effects can usually be felt within two weeks.

It taking them on an empty stomach could help, and that enteric-coated capsules are helpful.

Both factors could help ensure that the enzymes make it through the stomach and are absorbed in the intestine.

Many are recommending the brand Doctor's Best:
amazon.com/Doctors-Best-N…

Cautions

Some report feeling worse after starting, possibly due to inflammatory markers being released from clots.

Exercise caution, esp with higher doses.

Also, watch out for drug interactions, more here:
pharmd.substack.com/p/drug-interac…

3/ More resources

Here's a (just released) video from @gezmedinger, @doctorasadkhan, @resiapretorius, @dbkell about NK, LK, and SP.

Here's a particularly strong testimonial from @montnicole who experienced dramatic improvement after starting NK + SP.

https://twitter.com/montnicole/status/1586536070526619648

@organichemusic survey on NK, LK, and SP timing, dose, coatings, and others

https://twitter.com/organichemusic/status/1550749456009674752

@organichemusic thread on some intuition why these NK and SP together could be beneficial (she is on a roll!)

https://twitter.com/organichemusic/status/1554822340122447873

@PutrinoLab demonstrating a relatively simple microclot assay:

https://twitter.com/PutrinoLab/status/1601223290273398784

A biomarker would be an absolute game changer, and fascinating to track while taking NK/SP.

4/ If you're thinking of trying NK/LK/SP, you can use Eureka to analyze how each dose impacts your fatigue, brain fog, HRV, and more.

Plus, you'll be helping the community learn what works on who.

Click here to learn more:
eurekahealth.com/plan/anti-clot…