Announcing to the team we received acceptance at a top scientific journal of a 13 year study to test The Information Theory of Aging… 1/n #harvard 
With this discovery, we’re able to drive aging forwards and backwards in a mouse, and see the underlying processes that we believe cause us to age 2/n
The goal is to slow and reverse aging in the human body, to treat diseases by addressing their cause rather than the symptoms 3/n
The study suggests that aging is like scratches on a CD that can be polished off, or like corrupted software that can be reinstalled to reverse aging, as described in Lifespan 4/n
I’m so proud of the 60 person team and of Dr. Jae-Hyun Yang, lead scientist this past decade. He’s the guy at the end, to my right 5/n
Jae revealed that he wrote me a resignation email in 2021, it was so physically and emotionally difficult for him (and his family). Fortunately he never sent it 🙏 6/n
The lessons:
1. Aim the highest you can imagine
2. Don’t listen to the naysayers, they will always criticize what’s new or threatening
3. Never, ever give up. Have grit
4. Collaborate with people smarter & more skilled than you. It takes a diverse team to do the impossible 7/n
1. Aim the highest you can imagine
2. Don’t listen to the naysayers, they will always criticize what’s new or threatening
3. Never, ever give up. Have grit
4. Collaborate with people smarter & more skilled than you. It takes a diverse team to do the impossible 7/n
5. Always aim to improve your work
6. Utilize new technologies
7. Believe in yeast
8. What you do is more important than how long it takes you
9. Surround yourself with people who share the same goals and work ethic
10. Stick to what you believe in. Never compromise 8/n
6. Utilize new technologies
7. Believe in yeast
8. What you do is more important than how long it takes you
9. Surround yourself with people who share the same goals and work ethic
10. Stick to what you believe in. Never compromise 8/n
I was 39 when this project started in lab! In 2009, there was no such thing as a DNA methylation clock or CRISPR. It was initiated by postdoc Dr. Phillip Oberdoerffer and our lab’s manager Dr. Luis Rajman. Thanks guys. 9/n
The paper was rejected about 3 years ago. We improved the work for another year. We appealed. We won the appeal. We did another year of work. We merged the two papers, we did another year of work. We resubmitted & were accepted in Dec 2022. Publication date Feb 2023. 10/n
We dedicate the work to Drs. Michael Bonkowski (right) and Norm Wolf, who we lost on the journey
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