Daniel Gewolb, MD Profile picture
Dec 25, 2022 4 tweets 3 min read Read on X
62 y/o M presents with signs of raised intracranial pressure. CT shows a hyper dense mass crossing the corpus callosum. On MR, the mass is hypointense on T2WI, restricting diffusion, and homogenously enhancing along the periventricular surface.
#radtwitter #radres #neurotwitter ImageImageImageImage
The corpus callosum is composed of very dense white matter tracks. Only aggressive tumors or lesions that effect the white matter cross the midline through the CC.

Diff Diagnosis for CC masses

High grade astrocytoma/Glioblastoma
Primary CNS lymphoma
Tumefactive Demyelination
Dx: Primary CNS lymphoma

PCNSL has a highly variable imaging appearance. Classically, it presents as a hyperdense mass with restricted diffusion and relatively hypointensity on T2WI due to hypercellularity. The mass enhances homogeneously and may cross the CC. #Neurosurgery
High grade astrocytoma and/or glioblastoma have more necrosis with heterogenous rather than homogenous enhancement.

Tumefactive demyelination has less mass effect relative to the size of the lesion, peripheral incomplete ring enhancement and marginal restricted diffusion. @RSNA

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More from @daniel_gewolb

Dec 10
Back from Belize! 🇧🇿

🔷What is the most likely diagnosis in this 25 y/o F w/ a band-like scalp lesion and local alopecia?

#Medicine #radres #futureradres #ENT #Rheum #Neurology #neurosurgery #Ophthalmology #FOAMed Image
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Answer: Linear Scleroderma aka Scleroderma en coup de sabre

🔷Linear scleroderma is a focal form of scleroderma resulting in atrophy and alopecia of the frontal or frontoparietal scalp

🔷Atrophy involves the subjacent skull +/- underlying brain parenchyma (as seen in this case)
🔷Brain parenchymal abnormalities may have calcifications or micro-hemorrhage

🔷Linear scleroderma is associated w/ progressive facial hemiatrophy (Parry-Romberg syndrome) Image
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Read 4 tweets
Nov 27
⭐️ What is the most likely diagnosis in this asymptomatic patient? What would your recommendation be if any?

#ENT @ASHNRSociety #Medicine #radres #futureradres #Neurology #Neurosurgery #ophthalmology #FOAMed Image
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Answer: Benign-appearing notochordal lesion (formally ecchordosis physaliphora, EP)

💡 If no remote priors for comparison, recommend 6 month follow up which can be extended if unchanged at that time
🔷Pathologic nomenclature was revised from EP to benign notochordal cell tumor (BNCT)

🔷Notochordal remnants are a pathologic spectrum ranging from benign (EP/BNCT), indolent, intermediate, & aggressive chordomas
Read 7 tweets
Nov 24
⭐️What is the most likely diagnosis in this 40 y/o M presenting w/ 10 days of L neck/throat/ear pain, worsened by neck palpation and head turning?

🔷PMH: None
🔷ESR/CRP: Mildly ⬆️

#Medicine #Neurology #neurosurgery #ENT #radres #futureradres #FOAMed @ASHNRSociety Image
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⭐️ Answer: Transient Perivascular Inflammation of the Carotid Artery (Carotidynia or Fay syndrome)
🔷Pathology: Unknown inflammatory process of the carotid wall

🔷Epidemiology:
▶️Young and middle age adults
▶️No gender predilection
Read 7 tweets
Nov 22
What is the most likely diagnosis in this 30 y/o M presenting with seizures, fever & headache?

🔷CSF x2:
Worsening neutrophilic pleocytosis despite Abx
Negative infectious studies
No malignancy on cyto/flow
OCBs +

🔷CT CAP: normal
#neurology #medicine #radres @AlbanyMedRadRes Image
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Additional image 👇
#futureradres #Neurosurgery #FOAMed Image
Answer: FUEL “FLAIR-variable unilateral enhancement of the leptomeninges” in MOGAD

🔷MOG antibody-associated disease (MOG-AAD)

Path: MOG-AAD is an autoimmune inflammatory demyelinating disease targeting oligodendrocytes
Read 12 tweets
Nov 19
⭐️ Classic case: 45 y/o Female presents w/ intermittent R pulsatile tinnitus for 1-2 years, what’s the most likely diagnosis?

#meded #medicine #ENT #Neurology #radres #futureradres #neurosurgery @ASHNRSociety Image
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Answer: Glomus Tympanicum Paraganglioma

🔷PATHOLOGY: Benign tumor arising from glomus bodies along the inferior tympanic nerve (Jacobson nerve)
🔷CLINICAL:
▶️Vascular retrotympanic mass
▶️Pulsatile tinnitus
▶️Female predominance (~3:1)
▶️Generally middle age at diagnosis
Read 8 tweets
Nov 15
60 y/o F presents w/ several months of confusion, word finding difficulty & gait dysfunction

🔷What is your best guess and differential?

🔷More images in 🧵
#MedEd #radiology #Neurology #radres #neurosurgery #medicine #ENT #Ophthalmology #futureradres Image
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🔷More images 👇 Image
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Answer: Glioblastoma on pathology

🔷Imaging: Tumor, high grade glioma vs lymphoma

🔷This case of glioblastoma is not classic and has overlapping features with lymphoma
Read 11 tweets

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