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The Sato Lab (Kei Sato) Profile picture
@SystemsVirology
Dec 27, 2022 • 8 tweets • 5 min read • Read on X
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BREAKING🔔 The 15th preprint from G2P-Japan🇯🇵 is out @biorxivpreprint. We illuminated the virological characteristics of one of the latest SARS-CoV-2 lineages of concern, XBB, which was generated by recombination of two #Omicron subvariants. Please RT. 1/
biorxiv.org/content/10.110…
In late 2022, the Omicron subvariants have highly diversified. An example is BQ.1.1, which has convergently acquired amino acid substitutions at five critical residues in the spike protein: R346T, K444T, L452R, N460K & F486V. We reported it as below⬇️ 2/
Another variant of concern is XBB (aka #gryphon). First, two young talents, @jampei2 & @SpyrosLytras, showed that XBB emerged by recombination of two co-circulating BA.2 lineages, BJ.1 & BM.1.1.1 (a progeny of BA.2.75), during 2022 summer in India or its neighboring countries. 3/
We showed that the Re values of XBB lineages are comparable with or slightly higher than those of BQ.1 lineages, and notably, XBB and BQ.1 lineages are becoming dominants in Eastern and Western Hemisphere, respectively. 4/
Neutralization assay revealed that XBB is the most profoundly resistant variant to BA.2/5 breakthrough infection sera ever (!!). >30-fold more resistant to BA.2 breakthrough infection sera than BA.2, and >13-fold more resistant to BA.5 breakthrough infection sera than BA.2😵 5/
XBB spike is more fusogenic than BA.2.75 spike. Notably, the recombination breakpoint is located in the receptor-binding domain of spike, and each region of recombined spike respectively conferred both immune evasion and augmented fusogenicity to the XBB spike. 6/
Finally, we demonstrated that the intrinsic pathogenicity of XBB in hamsters is comparable to or even lower than that of BA.2.75, an ancestral lineage of XBB. 7/
Our multiscale investigation provided evidence suggesting that #XBB is the first documented example of a SARS-CoV-2 variant that increased its fitness (Re) through an recombination event rather than substitutions. 8/8

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More from @SystemsVirology

The Sato Lab (Kei Sato) Profile picture
Jun 6
#拡散希望 速報🔔 G2P-Japan🇯🇵の新しい研究成果「新型コロナウイルス変異株KP.3, LB.1, KP.2.3のウイルス学的特性の解明」について、プレプリント公開に先立って速報します。本研究では、最近いくつかの国で増加傾向にある、JN.1の子孫株である新しい3つの変異株の特性を検証しました。1/
春になり、JN.1の子孫株が出現し、それらが優勢になり始めています。そのひとつ、KP.2 (JN.1.11.1.2)の特性については、すでにG2P-Japan🇯🇵が論文として報告しています。2/
今回着目したのは、KP.2にやや遅れて出現した3つの株、KP.3 (JN.1.11.1.3)、LB.1 (JN.1.9.2.1)、KP.2.3 (JN.1.11.1.2.3)です。それぞれ、こんな変異を持っています。
（＊参考まで、JN.1=BA.2.86.1.1で、BA.2.86系統の子孫株）3/ Image
Read 8 tweets
The Sato Lab (Kei Sato) Profile picture
Jun 6
BREAKING🔔 Here I want to quickly report our new results from G2P-Japan🇯🇵 before the preprint publication. We have elucidated the virological characteristics of SARS-CoV-2 KP.3, LB.1 and KP.2.3 - progeny of JN.1. Please RT🔥 1/
Cf. A new one, KP.2 (JN.1.11.1.2), has been already elucidated. 2/
Here we focused on relatively new ones, KP.3 (JN.1.11.1.3), LB.1 (JN.1.9.2.1) and KP.2.3 (JN.1.11.1.2.3). These variants harbor these mutations⬇️ 3/ Image
Read 7 tweets
The Sato Lab (Kei Sato) Profile picture
May 20
#拡散希望 第2回新型コロナウイルス研究集会を、8月2日〜4日に東京・品川で開催します！　今年のテーマは「COVID-19の疫学、臨床医学、免疫学、ウイルス学」。新型コロナに関する科学のすべてを網羅した集会になるよう準備を進めています！ 1/
confit.atlas.jp/guide/event/co…
参加・演題登録はこちらから↓
今年は「オンデマンド配信」も予定しています。先約があったり、遠方で現地参加が難しい方や、医療従事者のみなさまにも広くご参加いただき、新型コロナの科学の最先端を知る機会を提供できればと思っています。2/
confit.atlas.jp/guide/event/co…
今年は、G2P-Japanが基礎ウイルス学を担当し、免疫学を⾼橋宜聖先生（感染研）、臨床医学を忽那賢志先生（阪⼤）@kutsunasatoshi 、公衆衛生学を押⾕仁（東北⼤）に担当いただきます。3/
confit.atlas.jp/guide/event/co…
Read 5 tweets
The Sato Lab (Kei Sato) Profile picture
Apr 27
BREAKING🔔 A new study from G2P-Japan🇯🇵 is out at bioRxiv @biorxivpreprint. We elucidated the virological characteristics of SARS-CoV-2 KP.2 - a progeny of JN.1. Please RT🔥 1/
biorxiv.org/cgi/content/sh…
Cf. This is KP.2 (aka JN.1.11.1.2). In spike, KP.2 = JN.1 + S:R346T, S:F456L & S:V1104L).

We remember that R346T was observed in BQ.1.1 and XBB lineages, while F456L is a hallmark of EG.5 lineage. 2/ Image
Transmissibility/fitness (Re): molecular phylogenetic-epidemic dynamics modeling led by Jumpei @jampei2 and Kaho showed that the Re of KP.2 is ~1.2-fold greater than that of JN.1. 3/
Image
Image
Read 6 tweets
The Sato Lab (Kei Sato) Profile picture
Jan 9
BREAKING🔔 The 32nd paper from G2P-Japan🇯🇵 is out at Lancet Infectious Diseases @TheLancetInfDis. We show the breadth of antisera induced by XBB.1.5 monovalent vaccine - comparison between infection-naïve and XBB-infected individuals. Please repost🔥 1/
thelancet.com/journals/lanin…
To control SARS-CoV-2 infection, the XBB.1.5 monovalent vaccine is now available. However, we found that natural infection with XBB subvariants, including XBB.1.5, does not efficiently induce humoral immunity against the infecting XBB subvariants, e.g. 2/
These observations raise the possibility that the XBB.1.5 monovalent vaccine may not be able to efficiently induce humoral immunity against emerging SARS-CoV-2 variants, including a variety of XBB subvariants as well as BA.2.86 and JN.1. 3/
Read 12 tweets
The Sato Lab (Kei Sato) Profile picture
Jan 4
BREAKING🔔 The 33rd paper from G2P-Japan🇯🇵 is out at Lancet Infectious Diseases @TheLancetInfDis. We elucidated the virological characteristics of SARS-CoV-2 JN.1 - a progeny of BA.2.86 (#Pirola). Please retweet/repost 1/
thelancet.com/journals/lanin…
This is JN.1 (aka BA.2.86.1.1; in spike, JN.1 = BA.2.86 + S:L455S. We remember that the L455 substitution, S:L455F, was observed in the XBB lineage (e.g., HK.3 and these are known as "FLip" subvariants). 2/ Image
Transmissibility/fitness (Re):
Molecular phylogenetic-epidemic dynamics modeling led by Jumpei @jampei2 and Kaho showed that the Re of JN.1 is apparently greater than that of BA.2.86 and others, suggesting that S:L455S can contribute to the increased fitness of JN.1. 3/
Image
Image
Read 7 tweets

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