1/ Do you know who this man is? 🧵
He’s Fredrick W Mott, an English 🏴surgeon who identified cells with multiple spherical inclusions packed in their cytoplasm in the brains of monkeys with trypanosomiasis.
He’s Fredrick W Mott, an English 🏴surgeon who identified cells with multiple spherical inclusions packed in their cytoplasm in the brains of monkeys with trypanosomiasis.
2/ In the early 1900s, he identified them as plasma cells in inflammation and called them morular cells (Latin morus=mulberry). He was later given the honour of having these cells named after him.
Image credit: doi.org/10.1002/jha2.5…
Image credit: doi.org/10.1002/jha2.5…
3/ It was actually William Russell, a Scottish 🏴physician before Mott, who recognised these inclusions contain immunoglobulin. The individual cytoplasmic inclusions (Russell body) are hence named after him.
Image credit: imagebank.hematology.org/image/4192/rus…
Image credit: imagebank.hematology.org/image/4192/rus…
4/ Don’t confuse them with Dutcher bodies, intranuclear inclusions that invaginate or overlie the nucleus. They were described by Dutcher and Fahey (NIC Bethesda 🇺🇸) in 1959 in Waldenstrom Macroglobulinemia.
Image credit: bit.ly/3XeknKO and bit.ly/3vSVGYU
Image credit: bit.ly/3XeknKO and bit.ly/3vSVGYU
5/ Want to learn more about morphology? Check out our interactive cases 👉
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#hematology #hempath #biomedicalscientist #medicalstudent #medicallaboratoryscientist
Subscribe today @ blood-academy.com
#hematology #hempath #biomedicalscientist #medicalstudent #medicallaboratoryscientist
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