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Dr Elisa Perego Profile picture
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Jan 12 • 6 tweets • 3 min read
The first sequences of SARS-CoV-2 from 3 years ago showed the novel coronavirus was similar to SARS CoV, the virus causing the severe SARS. This is why the Covid virus is called SARS-CoV-2. Many SARS survivors were ill for years or never recovered. Why then "living with" covid?
On the long-term health effects of the first SARS, see preliminarly a thread I curated in 2021 (#longSARS). We have been aware of the dangers of SARS CoV since early in the pandemic. This has been a huge red flag for SARS-CoV-2

The similarities between the novel coronavirus and SARS were already picked up in January 2020 in top scientific journals like @TheLancet. Concerns about the risk for a pandemic like the devastating "Spanish" flu pandemic of 1918 were also raised

thelancet.com/journals/lance…
"Living with" this dangerous SARS virus is something we shouldn't have been pushed into. The consequences for human health of this disaster will reverberate for generations

#LongCovid #longSARS
By the way, SARS-COV-2 is an airborne virus i.e. it spreads and lingers in the air a bit like cigarette smoke. And there was evidence and discussion of airborne transmission for SARS-CoV at the time of the early 2000s outbreak

bmj.com/content/378/bm…

nejm.org/doi/full/10.10…
I do agree with Dr Tedros in the video above, however, on the fact it's imperative countries do more sequencing of SARS-CoV-2: it's fundamental to find out about new variants as soon as possible after they emerge

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More from @elisaperego78

Dr Elisa Perego Profile picture
Jan 13
I've tweeted many times about it, but worth remembering: the biomedical literature and patient experience are crystal clear that acute and #LongCovid come with heightened, sometimes severe risk of cardiovascular—thrombotic events and sequelae. It was published in 2020—1 already
We're reading about a lot of cardiovascular events in the press, including among celebrities in their youth—middle age. In some cases, a covid link is established and even openly recognized. In others, there might be not: of course cardiovascular disease existed before covid!
We must remain concern about any raise of such events above the pre-pandemic average as well as the proven link between covid and cardiovascular—thrombotic sequelae, which we know to be documented even after mild and asymptomatic/pauci-symptomatic covid

#LongCovid
Read 10 tweets
Dr Elisa Perego Profile picture
Jan 13
I agree with MvanK that we need more research on #LongCovid. I also underline we already have a huge amount of research available since 2020 and 2021, which isn't translated into care and treatment. The "mysterious" trope is critical to deny people care for what we already know
We know #LongCovid is linked to coagulopathy i.e. coagulation issues, diabetes, myocarditis, pericarditis, arrhythmias and other cardiac complications, pulmonary embolism and thromboembolism, arthritis, various types of vasculopathy and endothelial dysfunction, immune dysfunction
lung impairment, including perfusion defects, microvascular damage to the lung bed and presumptive micro-clotting as shown by the VQ/SPECT scan cc @LongCovidItalia, multi-organ impairment including in the liver and kidney, metabolic problems, dyslipidaemia, and much more
Read 18 tweets
Dr Elisa Perego Profile picture
Jan 10
Many people ask for how long we should be keeping protecting ourselves from covid. Many cite being "tired" of the pandemic. Yes, it's a difficult period for many. But the virus doesn't care if you're tired. If you get severe acute or Long Covid, there might not be a turning back
Even for known commorbities of #LongCovid, for which treatment would be possible, access to care is severely restricted, unless you're wealthy. Some damage might be irreversible. Covid is still killing thousands a week across multiple countries. Cases fall and grow in new waves
We don't know if there will be a "cure" to restore previous health in all patients; when; and how accessible such "cure" would be (I obviously hope as everyone). You won't be "cured" anyway if you're dead. And people are still dying from treatable diseases for a lack of access
Read 4 tweets
Dr Elisa Perego Profile picture
Jan 10
A search for "covid-19" on the repository for medical papers PubMed currently holds 328,840 results. Not exactly a "medical mystery" right? Of course, we have *a lot* to learn about the disease. But I hope the press will spare us the "mystery" narrative

pubmed.ncbi.nlm.nih.gov/?term=covid-19
I say it again. There is still a lot we have to learn about acute and Long Covid. We need to translate knowledge into trials and treatment. But we're not talking about an unknown condition. We know SARS-CoV-2 infection is dangerous, with impact on basically all body systems
There is no justification for policymaking inaction as regards the spread of this dangerous SARS virus. There is no justification for the delay in looking for treatment, for a disease which was compared to SARS by knowledgeable actors since the early emergence of SARS-CoV-2
Read 5 tweets
Dr Elisa Perego Profile picture
Jan 9
The pandemic isn't over. Reinfections are rampant. #LongCovid and death will continue to rise as new variants spread and wreak havoc. We need to curbing the spread of this dangerous SARS virus, which is hitting the least privileged particularly hard. It's deranged not to do so
It's not human or ethical to have people infected at the hospital, where they go at their most vulnerable for getting medical care. It's not human or ethical to have children, some of whom cannot be vaccinated, to be infected and reinfected with this dangerous SARS virus
It's not human or ethical to have people who can't be vaccinated or don't have a good response to vaccination to be infected and reinfected with SARS-CoV-2. It's not human or ethical to have those who are immunocompromised or with commorbities to be exposed to covid
Read 5 tweets
Dr Elisa Perego Profile picture
Jan 9
Case report of a post-covid myocardial infarction (MI) in a 9-year-old. Negative for PCR, positive for antibodies.
MI due to total occlusion of the main coronary artery. Multi-system involvement: cardiovascular, gastrointestinal. Final diagnosis: MIS-C

ncbi.nlm.nih.gov/pmc/articles/P…
"A 9-year-old boy presented to the emergency department with 1-day duration of acute-onset chest pain. Other symptoms included nausea and mild abdominal pain." No previous and family history of cardiovascular disease, no known commorbities
Elevated body temperature of 38.1°C. Slightly increased to 38.6°C in follow-up, with persistent fever for 5 days.
Abnormal ECG findings. Multiple abnormal findings on bloodwork including high troponin, liver function tests, ddmer, ferritin, C rective protein etc.
Read 9 tweets

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