Jeff Gilchrist Profile picture
Jan 23, 2023 42 tweets 13 min read Read on X
Real life example of impact from COVID infection and why we need clean air

@ahandvanish taught a grad course on generative music at NYU, works with machine learning, data sonification (auditory equivalent of data visualization), and more ( hannahishere.com/about-me/ ). 🧵1/ Photo of Hannah Davis. Imag...
An unrolled one-page web view for this long thread that may be easier to read or share can be found here ( ). 2/
Hannah Davis was recognized by Time Magazine as one of the 100 rising stars from across industries and around the world for 2022 ( time.com/collection/tim… ). 3.
@ahandvanish was also brave enough to share her real-life experience of COVID infection that drastically impacted her processing speed ( ). 4/
She happened to have done some neuro testing just before her COVID infection where she scored being faster than 96% of people. 5/
After her COVID infection, she started having brain issues and decided to redo the test again where she found out her processing speed had dropped from top 96% of people down to only faster than 14% of people. 6/ Graph showing processing sp...
Hannah explains in her thread how low processing speed affects everything from basic communication with people (talking, texting) not only in how long it takes but how much information you understand about what you are reading/hearing. 7/
This unfortunately makes relationships harder to maintain. She goes on to describe how actions that require you to make fast decisions such as driving are much scarier or often not possible to do at all. 8/
Even common sense decision making is related to processing speed and can be difficult. 9/
Processing speed also impacts memory by limiting how fast you can register memories and emotional awareness in how long it takes to know how you are feeling. Low processing speed ultimately impacts identity in a serious way. 10/
"Processing speed impacts how much you can hold in your head, how you weave the world together and make sense of it, the thoughts that come up when you think about the people, places, ideas that you love. It turns those processes into just a void, a blank wall." 11/
Hannah Davis wants people to understand what can happen after you become infected with COVID and how much #LongCOVID can change you, potentially permanently. This is not just a "mild" virus and should not be treated as such. 12/
Long COVID is not just happening to her or a small number of people, but it is estimated that at least 65 million people worldwide have Long COVID with cases increasing daily. 13/
Hannah Davis and others have put together and published major findings, mechanisms and recommendations on the subject ( nature.com/articles/s4157… ). 14/
This is why it is so important that we improve the infrastructure to provide clean air like we did for water to end the cholera epidemics two centuries ago ( thetyee.ca/Analysis/2023/… ). 15/
Unfortunately we can't easily see how dirty the air is and in many locations including schools and workplaces but if you could see the air in some places, it would look more like the left glass of water compared to the right glass of water ( ). 16/
Would you drink the glass of water on the left? If not, why are you still breathing in dirty air in poorly ventilated indoor spaces? 17/ Image of glass on the left ...
If spaces are not being regularly tested and monitored, you may have no idea how clean (or not) the air is that you are constantly breathing in or if equipment is actually functioning properly. 18/
For example, look at these two Corsi-Rosenthal (CR) boxes and how dirty the filters got in a school after 7 months despite have windows open 95% of the time and CO2 levels below 1200 ppm ( ). 19/ Image of two Corsi-Rosentha...
They were still removing that much crap from the air that otherwise would have been breathed in by our children and the teacher. 20/
Do you commute to work using the subway? Check out how dirty the filter on this respirator got (compared to the brand new clean one beside) after a few months taking the subway 2-3 times a week ( ). 21/ Image of a Prescient-X Brea...
People not wearing a respirator are all breathing this into their lungs every day they commute. 22/
We breathe so much more air (11,000L) than we drink water (4L) or consume food (2L) every day so it is even more important that we ensure we are breathing in clean air ( nasa.gov/mission_pages/… ). 23/
This image really helps you understand the relative difference in the amount ( ). 24/ Graphical representation of...
Did you know if you measure the amount of CO2 in an indoor space you can actually calculate how much of other people's exhaled breath you are breathing in? This handy calculate will help you ( docs.google.com/spreadsheets/d… ). 25/
I have seen some school classrooms measure higher than 3,000 ppm of CO2 which means all of those children are breathing in 28.3 liters of other people's breath every hour! 26/
Can you imagine yourself or your child breathing in the equivalent of 14 bottles of pop full of other people's air backwash every hour? 27/ Image of a 2L bottle of pop...
If you think it too hard to upgrade the infrastructure in current schools and buildings, Engineers are up for the challenge. They raised entire cities (Chicago, Seattle) almost 175 years ago to combat harmful pathogens ( ). 28/
Would improving ventilation actually help? A study in Italy actually found classrooms equipped with mechanical ventilation systems decreased the relative risk of COVID infection by at least 74% compared to classrooms with only natural ventilation ( frontiersin.org/articles/10.33… ). 29/ Graph comparison between th...
For classrooms that were able to obtain higher than ventilation rates greater than 10L per second per student, risk of infection decreased even further to at least 80% lower. 30/
Cleaner air not only reduces the risk from COVID infection but all other viruses that transmit in aerosols through the air like influenza and other respiratory viruses. Click "Show replies" 👇 to continue. 31/
This is important as there have also been links found with other viruses that significantly increased the risk of neurodegenerative disease ( cell.com/neuron/fulltex… ). H/T: @DFisman 32/ Graphical summary of hazard...
Even influenza with pneumonia was significantly associated with five of the six neurodegenerative diseases studied and some exposures were associated with an increased risk of neurodegeneration up to 15 years after infection. 33/
Are you sure you want to keep getting infected by multiple viruses each year if you don't have to? 34/
Remember, as we saw above, clean indoor air isn't just about COVID, but it can help protect against other pathogens and air pollutants linked to various health problems which you can learn more about here ( ). 35/
Ventilation is also important when cooking as harmful particulate matter (PM) particles can be generated and breathed in so please remember to turn on your kitchen fan when cooking if you have one. 36/
I was able to measure PM2.5 particle levels were 10x higher when I was frying vegetables on my induction stove with the range hood fan turned off using a CO2.click Model E IAQ monitor that was 7.6m (25 feet) away in our family room ( co2.click/ecommerce/en/M… ). 37/ Graph showing particulate m...
If you don't have a hood fan, a HEPA filter or Corsi-Rosenthal (CR) box may help reduce PM in your kitchen as well. You can learn how to build your own CR box here ( ). 38/
If you aren't sure how the filters in air cleaners or masks actually block viruses and other particles that are much smaller than the sizes of the holes in the filtering material, this thread explains *how* they do that ( ). 39/ Image visualizing the Relat...
If you want to read about another real-world example of the impact of COVID infection but this time from cardiovascular complications you can find that here ( ). 40/
The wealthy also believe it is important to clean the air of indoor spaces as they went out of their way to do for the recent WEF conference in Davos, Switzerland. The conference space before was not good enough so they upgraded it to be #DavosSafe ( ).41/
A real-world example of a young woman 28 years old disabled from the pandemic, infected in March 2020 before the vaccines were available with only a mild illness at first but then she never got better ( thetyee.ca/Analysis/2023/… ). 42/

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Jeff Gilchrist

Jeff Gilchrist Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @jeffgilchrist

Sep 19
Variants: JN.1 vs KP.2 vs KP.3.1.1

What do the variant designations like KP.3.1.1 mean and how does it compare to JN.1? How important is just 1 mutation? Can 1 mutation potentially affect our immunity and how vaccines are designed? Read on to find out more. @paulseaman31 🧵1/ Structural alignment of the AF2-predicted RBD conformational ensembles in the complexes with ACE2 for JN.1 (A), KP.2 (B) and KP.3 variants (C). Structural alignment of the AF2-predicted conformations with high pLDDT values > 80.0 and the cryo-EM structure of the BA.2.86 RBD-ACE2 complex (pdb id 8QSQ). The RBD conformations are shown in ribbons. The sites of unique BA.2.86 mutations D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q are shown in blue spheres on panels (A-C). Mutation L455S in JN.1 is shown in red spheres on panel A. The positions of KP.2 mutat...
The web version of this article with nice table of contents and is easy to share with others can be found here ( ) or ( ). 2/ tinyurl.com/VariantsSummer…
docs.google.com/document/d/1q0…
Table of Contents Variant Designations (e.g. KP.3.1.1) - Parent & Child Lineages - KP.3 vs KP.3.1 vs KP.3.1.1 - Variants that Start with X How does this relate to our immunity? How important is 1 mutation? What variants are circulating now? - Canada - USA - United Kingdom - Europe - Asia - South America -Oceania
Variant Designations (e.g. KP.3.1.1)

You have probably seen people refer to COVID-19 variants with specific codes containing both letters and numbers like JN.1 or XBB.1.5, but what does that mean? 3/
Read 89 tweets
Aug 28
Virus update for Ottawa, Canada (Aug 28, 2024)

COVID-19 #Wastewater levels in #Ottawa are up again with the circulation of a new KP.3.1.1 DeFLuQE variant ( ). Wastewater is still being updated but on a weekly basis now. 🧵1/3 covid.gilchrist.ca/Ottawa.html
Image
New hospitalizations in Ottawa *due* to COVID-19, Flu or RSV are unfortunately increasing again. There were two big spikes over the past month ( ). 2/3 ottawapublichealth.ca/en/reports-res…
Graph of New Hospitalizations in Ottawa *due to* COVID-19, Influenza or RSV. Weekly stats available at ( http://covid.gilchrist.ca/Ottawa.html )
One virus is causing a lot more hospitalizations than the other two over the past year. Even at the lowest point at the end of March 2024, COVID-19 still accounted for more than 40% of hospitalizations between the three viruses and more than 80% for almost half the year. 3/3 Graph of % of New Hospitalizations in Ottawa *due to* COVID-19, Influenza or RSV. Weekly stats available at ( http://covid.gilchrist.ca/Ottawa.html )
Read 4 tweets
Aug 23
#Variant update for #Ontario, #Canada (to Aug 13, 2024)

Today's variant show is brought to you by the letters KP... Looks like KP.3.1.1 has really taken off and separated from the pack at 40% prevalence in Ontario. Graph tools by @Mike_Honey_ 🧵1/ Graph of top 7 COVID variants from PCR test genomic sequencing in Ontario, Canada. Visualization tool was created by @Mike_Honey_ ( https://app.powerbi.com/view?r=eyJrIjoiNzE5YzczODItMDQzMS00M2EzLWFjNWYtMjg3OTY3NTNhZDM3IiwidCI6ImRjMWYwNGY1LWMxZTUtNDQyOS1hODEyLTU3OTNiZTQ1YmY5ZCIsImMiOjEwfQ%3D%3D )
KP.3.1.1 has the #FLuQE mutations and also a key point in the spike protein deleted which gives it much more immune evasion than other variants. 2/
Testing with a recently released monoclonal antibody treatment (pemivibart) found that while it neutralized JN.1 and KP.2 with similar performance... ( ). 3/biorxiv.org/content/10.110…
Read 14 tweets
Jul 25
No Novavax JN.1 vaccine for Canada?

It seems Canada has not ordered any Novavax JN.1 vaccine doses for the fall which means this protein based vaccine option may not be available to anyone who wants or needs it. We are hoping you can help us change that. 🧵1/ English executive summary: A group of concerned stakeholders advocating for broader access to diverse COVID-19 vaccine options for Canadians, particularly those beyond the mRNA vaccines currently dominating the public offering wrote a letter to the Public Health Agency of Canada (PHAC), all the provinces/territories and immunization providers to address the pressing need for enhanced COVID-19 awareness and education, increased availability and access to protein-based vaccines, such as Novavax, which are currently limited in distribution.
A group of concerned stakeholders advocating for broader access to diverse COVID-19 vaccine options for Canadians, particularly those beyond the mRNA vaccines currently dominating the public offering wrote a letter to the Public Health Agency of Canada (PHAC)... 2/ Resume francais: Nous vous écrivons en tant que parties prenantes revendiquant un accès plus large aux différentes options de vaccins contre la COVID-19 pour les Canadiens, particulièrement au-delà des vaccins à ARNm qui dominent présentement l’offre publique. Nous exhortons l’Agence de la santé publique du Canada (ASPC), toutes les provinces et tous les territoires ainsi que tous ceux qui fournissent des vaccins à s’attaquer au besoin pressant d’une meilleure sensibilisation et éducation sur la COVID-19, ce qui inclut une plus grande disponibilité et un meilleur accès aux vaccins à base de...
...all the provinces/territories and immunization providers to address the pressing need for enhanced COVID-19 awareness and education, increased availability and access to protein-based vaccines, such as Novavax, which are currently limited in distribution. 3/
Read 10 tweets
May 22
Novavax JN.1 Vaccine Neutralization

Novavax revealed they had selected the original JN.1 variant as their fall booster and recently released neutralization results on non-human primates (Macaques) including a more recent KP.2 FLiRT variant. 🧵1/
Graph of JN.1 vaccine neutralizing response against JN.1 and JN.1 subvariants in non-human primates (macaques)
Graph of Novavax JN.1 Vaccine Neutralization Dose Schedule
Recall that the JN.1 variant became dominant in many parts of the world in December 2023 so by the time the fall 2024 vaccine program rolls out it will be almost a year old. 2/
Lets look more closely at the neutralization results that Novavax did provide in slide 14 of their investor presentation on May 10th ( ). 3/novavax.widen.net/s/gvwfqkhbhm/2…
Read 34 tweets
May 20
Indoor Air Quality: Wildfire Smoke & Cooking

With wildfire smoke season here, we all need to think about air quality inside where we spend most of our time. This thread provides multiple examples measuring the air quality inside my home from wildfire smoke and cooking. 🧵1/

Wildfire smoke making it difficult to see buildings in New York City from ( https://www.theguardian.com/environment/2023/jun/08/air-quality-record-smoke-hazard-wildfire-worst-day-ever-canada-new-york ).
Graph of PM 2.5 Wildfire Smoke Pollution Levels Inside & Outside House with significantly higher levels of PM outside and in garage, and higher levels of PM in unfinished sections of basement with very little PM in finished rooms and those with HEPA filters.
Graph from co2.click portal showing a massive spike in particulate matter (PM) levels past 50 ug/m3 on Christmas Eve. More info at: https://co2.click/
The web version of this article with nice table of contents and easy to share with others can be found here ( ) or ( ). 2/ tinyurl.com/AirQualityPoll…
docs.google.com/document/d/1x0…
Image
Particulate Matter (PM) Pollution

People now spend the vast majority of the time indoors. Adults in the USA with a 79 year life expectancy will spend on average 69 years inside of buildings and 54 of those years inside their own homes/residences ( ). 3/nap.nationalacademies.org/catalog/27341/…
Read 84 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(