“LINES, SINES, & SARS—will COVID become an endogenous virus? asks his eminence, T “#Kraken” Gregory. (AFAIK, no Nidovirus has ever become part of a metazoan genome & coronaviruses rely on an entirely cytoplasmic replication cycle.. so this is **exceedingly** unlikely)
The convo itself should be linked & saved for comic value (I’m blocked by all of the major participants—someone sent me screenshots..). It’s entertainingly revealing.. Ed covers some of the logical issues here
But a quick FYI: if you had COVID-19, it’s VERY UNLIKELY it invaded your reproductive organs. Not sure where that claim is coming from or if the data behind it is robust. (Ebola does actually do weird stuff like that and of course, still isn’t integrating into people’s genomes).
The only reasonable person on the thread gets the smack down from The Omniscient Infallible Ones With Many Followers Who Know Everything And Shall Not Be Questioned™️

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More from @macroliter

Jan 29
Ok.. this one merits a tear down 🧵 https://twitter(dot)com/TRyanGregory/status/1619423229537550336?s=20 Image
This exposes: (1) T Ryan Gregory’s very poor knowledge of immunology, and (2) his thirst for followers via alarmist rhetoric. Let’s discuss what he’s getting wrong here …
Firstly, just because a statement appears in the scientific literature does not make it correct. The authors fail to correctly interpret their finding of limited evidence of adaptive immunity in kids.
Read 7 tweets
Sep 18, 2022
Fantastic preprint from Dr. Cao's group in Peking-- huge amount of data in the preprint. I do, however, think it's worth questioning the somewhat frightening conclusions about imprinting, aka "original antigenic sin".. 🧵
As the SARS-CoV-2 coronavirus has evolved, our bodies have come to rely on a subset of antibodies, called "broadly neutralizing" for their ability to contain a wide range of different variants. 2/
BA.4 & BA.5 had a Spike mutation F486V that escaped a key set of bNAbs that many people easily made. This change helped give BA.4 and BA.5 an edge. 3/ 🔑
Read 17 tweets
Sep 10, 2022
Yo! Please don’t amplify armchair variant doom predictors. “A new variant is coming…” Yes, there will be new ones. But we usually don’t know which will actually sweep, if they’ll cause a wave 🌊 while doing so or just displace each other as case numbers remain steady 🧵. 1/
Please chill.. this isn’t a zombie movie.. so many on Twitter waiting with bated breath for the next Delta or Omicron. 2/
There are a several experts on here I trust to give an early warning. None more than @Tuliodna. 3/
Read 4 tweets
Jul 6, 2022
People say: “Spike is mutating so fast it is escaping vaccines.” But in fact the gene that encodes Spike, S, is not mutating any faster than the rest of the viral genome. 🧵
On a related note, people also say, “why should we immunize only against Spike, it’s a terrible vaccine target because it evolves so quickly”.. this is also mostly an incorrect statement. Why?
Mutations in viral RNA (or DNA) genomes occur at a steady rate which is intrinsic to the error rate of their nucleic acid replication enzymes. Host cells sometimes have defenses wherein the host will “fight” the virus by helping to mutate the viral genome (see APOBECs)..
Read 20 tweets
Jun 9, 2022
There’s been some back & forth of late between Worobey & Bloom about early SARS-CoV-2 genome sequences from China, focusing on the meaning of deleted SRA files. Anyone else notice that none of this debate concerns what the existing data say about the #OriginOfCovid ? 🧵
Jesse’s main argument is “because the early viral genome data from China is incomplete, we can’t make strong conclusions about the #OriginOfCovid.” This assertion has some serious flaws..
Let’s not let the innuendo distract us: Jesse does not provide an alternative interpretation of the existing data. He merely states that Worobey et al’s conclusions are too strong.. Between the lines though, he is obviously implying a lab leak *might* still be plausible
Read 15 tweets
Jun 8, 2022
💥 T’was long predicted that colorectal cancers would respond well to immunotherapy since like melanoma, these tumors carry heavy mutational loads & hence produce “neoantigens” that can be targeted as non-self when inhibition is removed. This was correct. nytimes.com/2022/06/05/hea…
I’m no cancer biologist but from what I understand both melanomas and colorectal cancers end up losing a key set of DNA repair pathways called “mismatch repair,”.. melanomas lose it & get even more mutated from UV exposure, colon cancers from mutagens in our diet..
And there are clearly implications for whether or not immunotherapy—H/T @JimAllisonPhD & colleagues— will work. In other cancers, like a suppose pediatric lymphomas, there probably aren’t so many mutations & hence not many neoantigens that can be targeted as “non-self” ..
Read 5 tweets

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