EXCLUSIVE: I interview lead author of Cochrane's #mask review, Tom Jefferson

He condemns the pandemic’s overnight experts, the multitude of scientifically baseless health policies & opens up about his disappointment in Cochrane maryannedemasi.substack.com/p/exclusive-le… @VPrasadMDMPH @davidemccune
This review comes off the back of 3yrs of governments mandating the use of face masks in the community, schools & hospital settings. Just last month, the WHO upgraded its guidelines advising “anyone in a crowded, enclosed, or poorly ventilated space” to wear a mask.
Jefferson says "governments completely failed to do the right thing and demand better evidence. At the beginning of the pandemic, there were some voices who said masks did not work and then suddenly the narrative changed."
Jefferson says "governments had bad advisors from the very beginning... They were convinced by non-randomised studies, flawed observational studies.  A lot of it had to do with appearing as if they were “doing something.”
Jefferson says in 2020, Cochrane held up their review for 7 months before it was finally published in Nov 2020. Those 7 months were crucial - it was when policy about masks was being formed.
Jefferson says "don't call me an 'expert'...

David Sackett, the founder of Evidence Based Medicine, once wrote a very famous article for The BMJ saying that ‘experts’ are part of the problem.

You just have to look at the so-called ‘experts’ that have been advising government."
"All you needed was for Tedros [from WHO] to declare it’s a pandemic and they could have randomised half of the United Kingdom, or half of Italy, to masks and the other half to no masks. But they didn’t. Instead, they ran around like headless chickens,’" said Jefferson
Jefferson says "I like Swiss cheese to eat -- the model not so much …It’s predicated on us knowing exactly how these respiratory viruses transmit, and that, I can tell you, we don't know....

..There’s no evidence that many of these things make any difference."

@goddeketal
For the full interview, sign up for free or upgrade and become a paid subscriber maryannedemasi.substack.com

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More from @MaryanneDemasi

Jan 25
We have responded to a critique of our 2022 analysis on statins (published in @JAMAInternalMed)

The critique was written by physician, podcaster @PeterAttiaMD

Join in the #statin discussion on Substack 👇👇

maryannedemasi.substack.com/p/response-to-… @pbyrne82 @mjones110164 @DrPaulMason

🧵👇
Too often, statin advocates will communicate a drug’s relative risk reduction (impressive number), without quoting the absolute risk reduction (trivial number), a practise we consider unethical (see graph)
The FOURIER trial was cited as evidence of benefit but it did not show a mortality benefit. In fact, there were more cardiovascular deaths and total deaths in the group taking the PCSK9 inhibitors compared to placebo, albeit not statistically significant.
Read 8 tweets
Jan 20
UK: Newly proposed guidelines say doctors may prescribe statins to adults, even if their risk of heart disease falls below the current 10% threshold.

Authorities say it could address the excess deaths from heart attacks & strokes seen since the pandemic.
maryannedemasi.substack.com/p/uk-statin-dr…
.@CMO_England says excess deaths from heart attacks since pandemic is coz people aren't getting statins & blood pressure pills BUT @carlheneghan shows no “evidence that lipid regulating & antihypertensive drugs were prescribed less in the last 3 years based on the NHS’s data.”
NICE says “high cholesterol is a significant risk factor” for heart disease, but ignores all evidence to the contrary.

Our study in @JAMAInternalMed demonstrated no consistent relationship between heart disease & lowering LDL-cholesterol with statins jamanetwork.com/journals/jamai…
Read 6 tweets
Jan 10
Trial data shows new FDA-approved Alzheimer's drug #lecanemab can lead to 'brain shrinkage'.

Advocacy groups celebrate its approval but critics question if the benefits outweigh harms & object to FDA decision without input from advisory committee.
maryannedemasi.substack.com/p/alzheimers-d… @RxRegA
No FDA advisory panel?

"The FDA once again has shown a lack of concern for the public, patients, and healthcare providers. Convening its advisory panel would have helped reassure everyone that the FDA’s decision was scientifically sound and transparent,” said @woodymatters
FDA 'accelerated' approval of #lecanumab accepted lower burden of proof for benefit e.g. showing lower amyloid protein in brain (surrogate marker) instead of showing a clinically meaningful benefit for person with Alzheimer's disease on a day-to-day basis.
Read 6 tweets
Jan 3
Have you been prescribed #rivaroxaban for #BloodClots?
A major trial of the anti-clotting drug rivaroxaban (XARELTO®) is now under scrutiny, after my BMJ investigation into the FDA's oversight of clinical trials.
maryannedemasi.substack.com/p/lancet-opens… @bmj_latest @rfsquared @drjohnm
Dubbed the "warfarin alternative," rivaroxaban has been prescribed more than 80 million times in the US alone. In 2020, it was rated 10th in the global sales rankings and generated almost US$7 billion that year.
The FDA identified numerous & serious data integrity deficiencies at 8 of the study’s 16 clinical trial sites. But when the trial was published in the Lancet in 2009 the investigators made no mention of the data integrity issues.
Read 6 tweets
Dec 8, 2022
🧵
Leaked email by former FDA criminal investigator says FDA "turned a blind eye" to Pfizer's "knowing submission of fraudulent data" involving the pivotal #mRNA trial.

@pfizer & @US_FDA respond to allegations 👇

theepochtimes.com/health/fda-bli… @IamBrookJackson @akheriaty @TheJikky Image
Allegations were made by a former federal agent in the FDA’s Office of Criminal Investigations (OCI).

This job of this law enforcement agent was to investigate healthcare fraud.

OCI consists of ~200 agents, hired from US Secret Service, FBI, IRS Criminal investigations unit etc
OCI was established by former FDA Commissioner David Kessler, off the back of the generic drug scandal in the late 80s. Kessler was determined to crack down on fraud after FDA employees were found guilty of accepting bribes from generic drug makers.
Read 7 tweets
Dec 1, 2022
Fauci during his recent deposition 👇🏼👇🏼

“There was no humility or admission of fallibility, no reflection that the lockdowns may have done more harm than good, especially to children’s schooling, or that vaccine mandates were pointlessly divisive” nypost.com/2022/11/30/as-…
Fauci exhibited stress when he was asked why he dismissed the “Wuhan lab leak” theory of the origins of COVID in favor of the less plausible “natural” hypothesis, and denied knowing about the proxy funding of dangerous gain-of-function research on viruses by the NIH.
Fauci was prickly when asked why he dismissed the advice of eminent medicos from the most prestigious universities in the US and the UK, who penned the Great Barrington Declaration in October 2020, urging a less extreme, more scientifically orthodox way of dealing with the virus.
Read 4 tweets

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