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Paul Maidowski Profile picture
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Feb 12 • 4 tweets • 3 min read
You all understand what this means (My guess if you’re reading this; and may know how to protect yourselves). BUT it’s a public policy problem.

We really need people who are NOT medical doctors or scientists to get involved.

Very roughly: cause-effect ImageImageImageImage
Understand also that higher-order nonlinear societal feedbacks are long since at work, explaining the schizophrenic (no dad joke there) character of our age.
Take good care everyone! The questions to ask should be clear by now.
“Should be clear” means they are not. Good high-level overview of the steaks before #H5N1 adds complexity, IF it does:

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More from @_ppmv

Paul Maidowski Profile picture
Feb 13
1. How can we end the COVID-19 pandemic (again)?

A thread for a human without bat immune system.
2. One way to end the pandemic is to declare its end.

At its 27 January 2023 meeting, the International Health Regulations (IHR 2005) Emergency Committee found that COVID-19 still constitutes a public health emergency of international concern (PHEIC). who.int/news/item/30-0… Image
3. The COVID-19 PHEIC may fall in May 2023 if member states force WHO DG @DrTedros' hand.

Having successfully defunded WHO over many years, members states hold the upper hand over WHO.

(This thread begins to respond to @RealCheckMarker kind prompt here.)
Read 11 tweets
Paul Maidowski Profile picture
Feb 11
I copied this quote to my bio, following @LongDesertTrain, because we HAVE to develop the capacity to hold multiple truths. SARS, climate, war - whatever else. We cannot govern the complex paths ahead with the false truths of the past.

Right up there with Dan Kaminsky. @kali0x2a Image
Said previously,
Rip Dan/Michael,
Read 5 tweets
Paul Maidowski Profile picture
Feb 11
1. Was war die Lebenserwartung von SARS-CoV Patienten 2003? Woran sind sie gestorben?

Was ist die LE von Erwachsenen und Kindern mit und ohne Reinfektionen in SARS-COV-2? Ist Long COVID = Long SARS?

Warum sind diese Fragen im 4. Jahre der Pandemie offen?
academic.oup.com/ooim/article/3…
2. SARS-CoV-2 und HIV-1 weisen molekulare Parallelen auf und teilen ein außerordentliches evolutionäres Potential. ImageImageImageImage
3. “This advantage is conferred by mutations in the V3 loop of HIV-1 gp120 and at the surface of the NTD and of the RBD in the case of the spike protein of SARS-CoV-2. NTD and RBD can evolve in concert by increasing their surface electrostatic potential.” mdpi.com/1422-0067/24/3…
Read 6 tweets
Paul Maidowski Profile picture
Feb 6
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.

#SIDU 230206
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).

Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.

Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Read 28 tweets
Paul Maidowski Profile picture
Feb 5
1. Congrats us, SARS-CoV-2 mutational fitness is steadily increasing thanks to unmitigated pandemic spread. Genuinely impressive to watch evolution happening live!

#SIDU 230205
2. Direct link: For XAY.2 and XBF, click on the enlarged grey dots on the right (dis/activate search function on top or add your own). nextstrain.org/groups/neherla…
3. Stone Reality Check Mark if you can explain the emerging wave pattern. What we were sold as endemic is no sustainable quasi-equilibrium state.

In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
Read 7 tweets
Paul Maidowski Profile picture
Feb 5
Did we do a vulgar thread yet? Sweat words are fantastic political language, essential power move at some times:
Brilliant thread: zero ducks given about what others think; what really bothers me is knowing what awaits those who bought into the bullshit. - Many cannot intellectually evaluate such risk themselves (no value judgement! They have other qualities), hence fall for the grifters.
Read 4 tweets

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