Dr. John Brooks, an internist at CDC office of prevention, speaks about #mpox. He notes that we've seen declines worldwide in new cases. 2/ 
Mpox likely transmitted most via contact with skin and the anorectal area. #CROI2023 3/
Dr. Brooks says, "We don't really know" why #mpox has declined so dramatically. He speculates vaccination and sexual behavior change in gay and bi men likely contributed. He does not mention my theory that the virus ran out of people with high frequency of new partners to infect.
Dr. Brooks calls for completion of the clinical trial of antiviral TPOXX , something that is difficult without many cases of #mpox occurring. He says people need to get vaccinated against mpox now before Pride season returns. #CROI2023
Dr. Sharon Frey, Clinical Director, Center for Vaccine Development, St. Louis University: MOLECULAR PATHOGENESIS AND THERAPEUTIC TARGETS FOR MPOX VIRUS lecture
Jynneos has been vaccinated intradermally:
Jynneos has been vaccinated intradermally:
Dr. Frey compares smallpox and #mpox at #CROI2023. "The presentation of mpox when it is sexually transmitted is very different from what we know of mpox in the past."
Dr. Frey reviews the history of smallpox vaccination. #CROI2023
Post-9/11, Iraq war era, Bush's administration was afraid that Iraq would use biological warfare. It turns out Iraq did not have smallpox on hand. Regardless, a program began to develop a new vaccine for smallpox. #CROI2023
The history of #mpox. #CROI2023
Dr. Frey says that quote about the virus disappearing because of ecological changes has the matter backward.
Dr. Frey says that quote about the virus disappearing because of ecological changes has the matter backward.
A play-by-play of the 2022 #mpox outbreak. Note that researchers later realized there had been signs of the virus in the UK by early April. #CROI2023
The CDC's John Brooks says that there are an est 2M Americans who would be good candidates for #mpox vaccination, because they are a man who has sex with men at risk of sexual acquisition and/or a person with HIV. 1.2M doses have been given; only 470,000 people have both doses.
A PhD student from @fredhutch says there has been "historical revisionism" going on in the talks in today's session. Yes, he says, there was decrease in sexual activity. "I think the LGBTQ community felt very let down by the public health infrastructure."
The @fredhutch student says, "We kind of had to take care of ourselves." He refers to the delay in the vaccine arriving on US shores. "I don't mean to tell you that this is bad or anything, but I don't necessarily think this is as rosy as being presented." (Applause)
"Now is the time to protect yourself. Prepare to be protected so you can take care of yourself in the future," said Dr. John Brooks of CDC at #CROI2023, anticipating that #mpox might rise again with the arrival of #LGBTQ Pride season. Will we see another mpox summer?
@MegDoherty_HIV of @WHO in Geneva says there's no guarantee that the public health emergency of international concern regarding #mpox will continue. She asks about the best way to continue monitoring and surveillance and not to lose momentum in combatting the virus. #CROI2023
Dr. John Brooks says, "We have the tools that work, how do we make sure we have equitable access to those around the world." The problem of #mpox, he says at #CROI2023, is growing in W and Central Africa.
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