Thread by @andersgranholm

#MethodMonday 9: Interpreting subgroup analyses
doi.org/10.1001/jama.2…
This articles discusses the interpretation and assessment of the reliability of subgroup analyses results - from both trials and meta-analyses. Most important points are covered 1/..

although covering everything in a single paper is difficult. The article gives an overview of the key considerations and also describes how most trials/meta-analyses have limited power for subgroup analyses, and that we consequently need to be careful with interpretations.. 2/..

Both of subgroup analyses showing effects (may be due to random chance and multiple testing) and those that do not firmly show effects (which do not exclude underlying differences) 3/..

More next week - see

https://twitter.com/andersgranholm/status/1609912935320780800?s=20&t=fTDb6Fu57coF3sqqxofNlA

for an introduction to these threads. 4/4