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Anders Granholm Profile picture
Anders Granholm
@andersgranholm
MD, PhD-student, Intensive Care @Rigshospitalet. @INCEPTdk. Clinical trials, evidence-based medicine, research methods, #rstats, Bayes.
Feb 27, 2023 • 4 tweets • 2 min read
#MethodMonday 9: Interpreting subgroup analyses
doi.org/10.1001/jama.2…
This articles discusses the interpretation and assessment of the reliability of subgroup analyses results - from both trials and meta-analyses. Most important points are covered 1/.. although covering everything in a single paper is difficult. The article gives an overview of the key considerations and also describes how most trials/meta-analyses have limited power for subgroup analyses, and that we consequently need to be careful with interpretations.. 2/..
Jan 16, 2020 • 11 tweets • 6 min read
#65trial Primary outcome of 90-day mortality not "statistically significant", but point estimate favours perm. hypotension. Can a Bayesian re-analysis help us interpret these results? #CCR20 (1/...) First, the best way to interpret frequentist 95% CIs that I have encountered (@EpiEllie) is to consider them to be like ring tosses - either they contain the true value or they don't: medium.com/@EpiEllie/havi… (2/...)