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Paul Maidowski Profile picture
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Mar 1 • 5 tweets • 3 min read
1. Does SARS strain XBB.1.5 replicate in retina or tear duct?

Practical implication for planners would be procuring N95 masks w/eye protection as PPE eg for HCW in hospital.

We just removed ANY protection/#Maskenpflicht in Germany so joke's on us, but worth keeping an eye open.
2. Links
thelancet.com/journals/lanmi…
cell.com/stem-cell-repo… (surely there's much more)

Thanks to @RealCheckMarker for warning most consistently, as the precautionary principle suggests.
3. Critically, this polemical lecture. I'm not sure I'd recommend following along, as I think it fails to follow the precautionary principle; but could also be rigorous scientific argument - you be the judge. Anecdote from the start of the eyeborne plague: bmjophth.bmj.com/content/7/1/e0…
4. This kind CM312 message meets the eye too. (I'm half joking in this thread for the eye-catching puns, but also note that XBB.1.5 has high hACE2 affinity and may efficiently infect through ocular surface epithelia for all I know.)
5. Behold and see: I'm still mostly just trying to understand what the plan for the coming years is. If we're optimizing SARS for another few years, You Bet this will be a good investment.

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More from @_ppmv

Paul Maidowski Profile picture
Mar 3
1. How can we solve climate and SARS?

Aviation drives the COVID-19 pandemic and climate breakdown.

Quarantine of intercontinental travelers at airports will (1) stop the pandemic - no need for lockdowns - and (2) buy time to rebuild supply chains for climate (IHR 2005).

Focus:
IHR 2005: cdc.gov/globalhealth/h…
2. This is how pandemics are ended in the modern age. It is harder now than in SARS 2003, given higher international mobility and a more rapidly evolving pathogen.
Read 14 tweets
Paul Maidowski Profile picture
Mar 2
1. In the SARS era, self-determination requires international cooperation. Image
2. Self-determination en.wikipedia.org/wiki/Self-dete…

Background en.wikipedia.org/wiki/Alma_Ata_…

The central lesson of SARS 2003 we still ignore:
3. Scholars, where are you in THE public health question of our times? SARS is a neurocognitive problem. Damage is cumulative and progressive; ignoring is not an option.

It's been eeriely quiet in the intellectual department!?
Read 16 tweets
Paul Maidowski Profile picture
Mar 1
Viral thread. Note that the UCSF studies found no evidence of Long COVID as an autoimmune disease.

Cannot be ruled out yet, but "what appears to be the most rigorous assessment of autoimmunity yet in long COVID didn’t find evidence of it." - Of interest also to ME/CFS patients. Image
2. What is ahead in the coming years?

States may force WHO to end the COVID-19 PHEIC.

This means freedom for SARS-CoV-2 to transmit and mutate unmitigated as the legal foundations for genetic surveillance, and test & trace, are removed in many countries.
3. Don't get lost in immunological detail that few people can follow -- and don't need to IF we end the pandemic. How?

Like every other pandemic by international cooperation (states under WHO guidance). THAT's the big story no one talks about.

Details:
Read 10 tweets
Paul Maidowski Profile picture
Mar 1
1. Calling good or goofy people

Today mask mandates ended in Germany. We saw the WORST increase in excess mortality of all major economies, with the possible exception of China, so that’s obvs an epic, deadly policy error. But there’s more
2. Actually there's not! It is that simple.

You don't get to end mask mandates, the only measure that helps after SARS variant XBB.1.5 mutated around all vaccines and treatments in record time, and get to claim you "ended" "the" "pandemic."
3. Western governments act like a mechanic who finds pressure low on a brake. What do they do?

Annoyed because they tried fixing it before, the mechanic doesn't fix the brake. This time they discard the whole brake system.

They take out ALL brakes, so they cannot break again. Image
Read 12 tweets
Paul Maidowski Profile picture
Mar 1
1. As a political scientist, my main question is why it took three years for most scientists to face reality. Biological warfare is a distinct possibility in the future, accidents happen even in benign or dual use research, and regulation and oversight are historically poor. 😂🤡
2. Read more, talk less, is generally good advice for people who don’t understand the precautionary principle or can’t be bothered to think questions to the end.
3. Understand that the origin question doesn’t even matter *except for law enforcements and prevention of future pandemics.*

SARS-CoV-2 eradication/elimination takes the same steps regardless of origin as SARS-CoV eradication in 2003. We know it will work sooner or later. 😈😴🤷‍♂️ Image
Read 4 tweets
Paul Maidowski Profile picture
Feb 16
Anyone is invited to do more professional modeling of long-term excess mortality trends, given the molecular and mechanistic analyses we share (of SARS pathogenesis) and politics (show your assumptions).

This is at best high school algebra. If I can do this, so can anyone else!
Before anyone thinks the above 'extreme' scenario is extreme, reread the available literature. If 1 out of 3 infected experience PASC or a form of Long COVID and many of them develop acquired lymphocytopenia, then the above is an underestimate.
Thought experiment II: worst case.

What does @RealCheckMarker say when she claims "SARS experts say it is no extinction level event"?

Recall such a no-policy world exists only in computer models.

In the real world, people read twitter, learn, wear N95 masks, and change policy.
Read 7 tweets

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