Thread by @E_A_Karlsson

I would like to clarify recent statements in the press regarding the ##H5N1 virus detected recently in #Cambodia that were taken out of context. The confusion surrounds the implication that the virus has already gone “through” humans, and may be misinterpreted. (A thread - 1/)

For clarification, #H5N1 virus sequenced from the case in Cambodia shows certain changes that are anticipated and have been found in previous avian and/or human strains when they go from a bird to a human. (2/)

This does *NOT* indicate that the virus is mutating or adapting to become human-to-human transmissible, nor does it state that the virus has already transmitted between humans. (3/)

The Cambodian #H5N1 sequence, available on @GISAID, indicates presence of natural changes previously found in both avian viruses and/or other isolated human cases. The virus does *NOT* have the PB2627 or HZ225 mutations experimentally associated with mammalian transmission. (4/)

The small adaptations we observe have been detected in spillover events into humans in the past, and have not resulted in sustained human-to-human transmission. **Rigorous experimental analysis is necessary to evaluate the effect of these mutations on this specific virus.** (5/)

#AvianFlu is of the utmost concern. However, any implication that this #H5N1 virus is fully human adapted or transmissible between humans can lead to unwarranted fear. It is important that we continue to go with scientific, accurate and balanced information. (6/)

@PasteurCambodia continues to work with Cambodian and international authorities surrounding this case, and no implications of human-to-human transmission have been found. (7/)