1/ #Cocaine is a powerful stimulant drug that has been around for thousands of years. It was originally used by indigenous people in South America for religious & medicinal purposes, and was later introduced to Europe and the US in the late 19th century.
2/ Cocaine works by increasing levels of #dopamine, a neurotransmitter that regulates pleasure and reward, by blocking its reuptake leading to an accumulation in the synpatic cleft. This leads to feelings of euphoria, increased energy and alertness, and decreased appetite.
3/ Serotonin and norepinehphrine reuptake are also inhibited, leading to increases in those neurotransmitters as well. Sodium channels are also blocked, slowing down the action potentials, thus leading to its medical use as a local anesthetic.
4/ Cocaine is typically used by snorting the drug through the nose, but it can also be smoked or injected. It is often used recreationally in social settings or to enhance performance, but can quickly lead to increased tolerance ➡️ dependence ➡️ withdrawal ➡️ addiction.
5/ Cocaine use can have serious physical and psychological effects on the body and brain. These can include heart attack, stroke, respiratory failure, seizures, anxiety, depression, and psychosis such as its trademark #formication, or feeling like bugs are crawling on the skin.
6/ Cocaine is illegal in most countries, including the United States. It is classified as a Schedule II drug, meaning it has a high potential for abuse but also has some accepted medical uses, such as a local anesthetic for certain procedures.
7/ Sigmund #Freud was a well-known user of cocaine and wrote extensively about its effects. He believed that cocaine could be used to treat depression and other mental health conditions, but later abandoned this belief and acknowledged the dangers of the drug.
8/ In the United States, cocaine use has been on the rise in recent years. According to the National Survey on Drug Use and Health from @samhsagov, the number of people who reported using cocaine in the past year increased from 1.5 million in 2015 to 2.2 million in 2019.
@samhsagov 9/ Cocaine has often been portrayed in popular media as a glamorous and exciting drug, leading to its romanticization and normalization in some circles. However, the reality of cocaine use is far from glamorous, and can have serious health consequences for users.
@samhsagov What do you think of the glamorization of cocaine in the media, such as the recent movie #CocaineBear? Share your thoughts below, and make sure to follow along for more education via #SubstanceSaturdays
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1/ 💊🧪👨🔬 #Methylphenidate was first synthesized by the chemist Leandro Panizzon in the 1940s. It wasn't until the 1950s that its therapeutic potential was recognized, and it was later introduced as a medication under the brand name #Ritalin.
2/ 😴😞🚀 In the early days, methylphenidate was primarily used to treat depression and fatigue. However, its stimulant properties were soon recognized as helpful for treating ADHD and narcolepsy.
3/ 🧠🚀 Methylphenidate works by blocking the reuptake of dopamine & norepinephrine, which increases the levels of these neurotransmitters in the brain. This leads to 🔼 activity in the prefrontal cortex, which is involved in executive functioning, attention, & decision-making.
1/ The concept of "hysteria" has a long and troubled history in psychiatry. It dates back to ancient Greece and was initially used to describe a wide range of physical and mental symptoms in women.
2/ "Hysteria" comes from the Greek word "hystera," meaning uterus, reflecting the historical belief that women's mental & physical symptoms were related to the uterus and its movements. This belief led to the notion that women's symptoms could be "cured" by removing the uterus.
3/ Over the centuries, the diagnosis of hysteria was used to blame women for their own suffering and pathologize normal emotions and behaviors. This led to a widespread belief that women were inherently unstable and prone to mental illness.
1/ Adderall is a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy; it works by increasing the levels of neurotransmitters in the brain, including dopamine and norepinephrine.
2/ Common side effects of Adderall include loss of appetite, trouble sleeping, and stomach problems. More serious adverse effects include heart problems, anxiety, mood swings or changes, and potential for dependence.
3/ Adderall is available in immediate-release and extended-release formulations, and it can be taken orally in tablet or capsule form, as well as some liquid formulations and oral disentegrating tablets (ODT): Adzenys, Dyanavel, Mydayis, and Vyvanse are all essentially Adderall.
1/ #Xylazine is a sedative and analgesic drug that is commonly used in veterinary medicine to sedate and immobilize animals. It is also used as an anesthetic in laboratory animals and as a tranquilizer in horse racing.
2/ Xylazine is a Schedule III controlled substance under the United Nations Convention on Psychotropic Substances, meaning that it has a potential for abuse and dependence, and it should be used under strict medical supervision. One of its nicknames is "#tranq".
3/ Unfortunately, Xylazine is being used to contaminate the drug supply, and it is being sold as a street drug. This is a dangerous practice as Xylazine can cause serious side effects, including respiratory and cardiovascular depression, and even death in high doses.