So, exasperated with the total lack of mitigations against a pandemic, I settled in to write one of my verbose threads...then realised I'd done it already and the situation hasn't really changed much...aside from getting worse!

We STILL have next to no

investment into the future of clean air, no public awareness of viral prevalence (SARS-CoV2, and its' mates), little ability to act altruistically because testing has evaporated and supported isolation remains a figment of most people's imagination...there's nothing safeguarding
our workplaces, schools, universities, public transport, shops or other public spaces, no masks, mis/dis-information is rife and anti-vax narratives now echo round the house of commons thanks to certain feckless mockeries of public representatives...

Most people think the COVID
pandemic is over, that it's now just a cold...some even think it was made up and conspiracy abounds wrt how it has been used to poison/brainwash/reset/kill/or fool us into electing Mr Gates as Emperor of the the planet...🙄

Out of sight, out of mind, ignorance is bliss, and to
do anything outside the realms of "2019 normal" is some kind of crime against humanity.
Some of the press lambast the notion that an emergency resulted in extreme measures, they bash those responsible for implementing policy (rightly, weirdly) because their politics took priority
over public health, one rule/party/opticians appointment for them, quite another for everyone else...but they neglect to mention, ironically, that the eagerness to move on/ignore and reluctance to enact sensible, timely measures, actually resulted in more extreme restrictions...
Perhaps the worst thing is that the shoddy justification for ignoring population-scale risk, for assuming that vulnerable people would jolly well just have to get on with it, for disregarding long COVID and other morbidity, and for allowing children to be repeatedly reinfected by
a virus that NOBODY on this planet fully understands, is actually in a much worse state than it was when the "strategy" was announced...not to mention that our beloved #NHS has been brought well and truly even closer to the brink than I ever thought possible...
A strategy that
relied upon vaccination has systematically failed to protect the young, and, along with testing, CMDUs and everything else, is being wound down in the way that roadies dismantle a stage after a concert. I won't go into vaccine strategies, I'll run out of tweets, suffice to say...
The fact is, there is SO little provision for the vulnerable, most of all the #forgotten500K with profound immune deficiency, that many are completely trapped between concern for their own/family's safety and the MASSIVE peer pressure from literally everyone else moving on...
this isn't the public's fault, as my thread from last year says, we SHOULD mainly focus on our individual risk, but this relies upon adequate provision of public health...

There seems a UK-centric aversion to prophylactic therapies that might actually allow vulnerable folks to
take more risks...it took SO long to appraise #Evusheld that SARS-CoV2 eventually outpaced its use...of course, other countries used this to its best and achieved a period of relative solace for their most vulnerable...
Our monoclonal therapies are dropping like flies, and even
if we could overcome some limitations by increased dosing, nobody wants to pay for it...how much do ICU beds cost again?
So, the idea is to provide therapeutics to prevent severe disease...but we're dismantling the CMDUs, plus @NICEComms are proposing to only keep Paxlovid as an
acute therapy...not too many options there, esp with the ritonavir issue...there are one or two other agents in the pipeline, but WHERE are the combination trials? How long before monotherapy breeds resistance as is so easily done in culture? This is one comparison to influenza
that IS valid!
Where is the investment in further research into better vaccines and therapeutics? Have we not learned the lesson of having poor pandemic preparedness yet?
Of course we're all tired of this, but I can assure you that the vulnerable are more so...plus they can't yet
take a rest. They can't even enter a hospital safely to access treatment because people still haven't grasped such confounding concepts as airborne, aerosol and RIDICULOUSLY INFECTIOUS VIRUS...

getyarn.io/yarn-clip/289f…
Imagine being the only family who's kid can't attend school, who can't take the bus, can't have a family Xmas, and can't "get back to normal". Many people have decided to take the risks, of course mental health is critical, but many simply can't.
When will it dawn on those who
dictate policy that to ignore a pandemic, to do nothing to minimise prevalence, to allow FIVE waves per year, just serves to prolong the madness...?

So, as you can probably tell, this thread is more of a rant than any kind of sensible science-based blurb, and I'm not quite sure
where it will end...but I implore those currently, or soon to be in a position of power to listen and care for the millions of people that remain at risk. "living with COVID" has meant ~30K haven't since spring 2022, and millions more have to endure the long term consequences. If
nothing else, recognise the impact on our workforce, our NHS, and the future implications for our kids...

I expect I'll get a load of plonkas saying I'm saying this to sound important etc., well, whatever, all you really do is show you're incapable of walking in other people's
shoes, or acting outside of your own interests...plus, I'll hazard a guess you'll have an anonymous account anyway! 🤖🤖🤖

Finally, a huge nod to those that really DO care, and support others even though they have their own struggles during such times.
@LongCovidKids @cv_cev
@LongCovidAdvoc @LongCovidSOS and so many others...🙏🙏🙏

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More from @SGriffin_Lab

Mar 15
Today is #LongCovidAwarenessDay
This is SO important, because it's likely that a great many people are NOT aware of it...
Unseen disabilities and chronic health conditions are something that millions of Brits face and deal with on a daily basis.
This isn't helped by black and
white judgemental nonsense from folks that don't understand the nature of such things.
Remember the whole nonsense around disability benefit fraud in the 2010s, people with blue badges being attacked when they didn't have a wheelchair in their car boot?
Sometimes people can
outwardly seem to function reasonably normally in public (ideally with reasonable adjustments in place), but to carry on like that costs them dear when they get home...
Then, there are the people that remain unseen, forgotten, behind closed doors and relying on others for their
Read 12 tweets
Mar 8
So, COVID vax entering preschool programme is frowned upon by some...after all "kids are all infected anyway, and they don't get sick"...a 🧵

This excellent paper is often cited to support that protection from infection is equivalent to vaccines...

nejm.org/doi/full/10.10…
Sure, protection from infection and hospitalisation appear better in the infected cohort...

BUT, what's sometimes missed is the actual numbers reflecting how we get to these pretty graphs...

193K infections, 309 hospitalised, 7 died
273k vaccinees, 15 hospitalised, 0 died
Other important points:

The vaccinated cohort included either one or two shots...we know from adults that three is best, so efficacy could theoretically be improved.

Vaccinating pre-infected kids improves protection, the authors recommend boosters for both vaxd & infected kids
Read 16 tweets
Feb 26
So, according to certain cardiologists, MPs, disgraced former Pfizer employees and Harvard profs, non practicing pathologists, signers of declarations, presenters on nationalistic news channels, members of groups with monosyllabic acronyms and coloured pebbles, Z list celebs, a
worryingly large cohort in MSM, proponents of "evidence-based" pigeon chess, some in PH focused upon individual rather than population scale risk, and a plethora of anonymous social media accounts, the vast majority of the population is suddenly at risk from all manner of cardio-
vascular, or other terrible ways we might meet our ends, and whoever is left will be unable to have kids, or be put on some kind of trial for supposedly being paid and/or influenced by former software developers or "the WEF", all in a kind of end of WWII reenactment party...
Read 4 tweets
Feb 17
@georged00rs @AnnLHowarth @NICEComms The vaccines were trialled with efficacy end points concerning the prevention of hospitalisation, severe disease and death.
Transmission is a separate issue, there are very few vaccines that provide sterilising immunity, and this is always for invariant viruses...not like SARS2.
@georged00rs @AnnLHowarth @NICEComms However, there was clear efficacy vs transmission during the Wuhan/Alpha stages, which matched the vaccines.
Delta (also beta and gamma before) showed us the first signs of escape from antibodies, but like most biological concepts this is a spectrum.
Omicron and its offspring
@georged00rs @AnnLHowarth @NICEComms now represents a considerable genetic distance from the Wuhan strain. But, protection vs severe disease remains, at least for mRNA vax...less so for killed vax like in China.
Our antibody responses are therefore mismatched, are complicated due to prior infection/vax history, and
Read 12 tweets
Feb 15
This is getting beyond a joke...
JC is now accusing HCW following guidelines by @NICEComms of inflating #COVID deaths via iatrogenic means...yes, killing patients with medicines.
I'm not a clinician, but I do know that e.g. diamorphine and medazolam aren't given lightly.
JC is
also of the opinion that many of those who succumbed would have simply got better if left without intervention...
He goes to the trouble of explaining "evidence based medicine" whilst showing purely associative, speculative and offensive "correlations" between spikes in drug use
and the first two waves...
I wonder, what in the PRE-VACCINE era might have caused a load of palliative drugs to be needed during pandemic waves? Not that JC advocates vax anymore either...🙄

He gets the years wrong, wrongly asserts that COVID pneumonitis/ARDS was treatable with
Read 9 tweets
Feb 6
JC used to be a half-decent Sci Comms outlet, helping folks make sense of the pandemic.
Now, he promulgates blatant anti-mRNA (not a vaccine, apparently 🙄) 💩 with a chap who is an expert in rock pools and paddling (perhaps avoid both on British beaches at present?).
Aside from the massive viewing figures and the number of stumbles as JC looks down at his script, this is one of the worst examples of biological understanding I've ever witnessed.
I won't post the link, but a few examples...
1. Apparently mRNA vax are completely different to
ye olde vaccines from the good old days, which were "ALL dead or attenuated" except for yellow fever where "the antigen is essentially alive"...these "don't use the body's own genetic apparatus to produce them"..."it's a completely different thing with a completely different
Read 20 tweets

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