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Mar 15 • 5 tweets • 2 min read
🇺🇸 30,311 babies followed from birth to 6 months, of whom 10,893 were born following #CovidVaccination in #pregnancy.

👉🏻 Protection against COVID infection in the delta period was 56%

👉🏻 In the omicron period, 13%

1/
nature.com/articles/s4146…
This study quite nicely shows how protection declines over time as maternal antibodies wane. For delta, protection against infection is:

84% in the first two months

62% in the first four months

56% in the first six months

2/2
Important additional note 👇🏻
Second note! Clare Craig asked why we can’t just divide COVID cases by number of babies and compare the rates. For anyone interested in the analytic approach, the answer to that is here…
The thread has come out kind of messy in the tweet above, so starting further down…

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More from @VikiLovesFACS

Viki Male Profile picture
Mar 4
@toadmeister Hi Toby! Our most up to date information on births and newly registered pregnancies in the NHS (to October 2022) shows no decline in either... 1/

@toadmeister It’s worth noting that the HES dataset, which you’re using there, isn’t yet finalised (though it will be shortly). So some births in the most recent months are not yet included in the dataset… but that doesn’t mean they didn’t happen. 2/

@toadmeister And here's more from an epidemiologist working on these datasets... 3/

Read 4 tweets
Viki Male Profile picture
Feb 24
@DrAseemMalhotra Hi Aseem! It would be very surprising if this one study had really found what the author claims, given the overwhelming body of evidence now showing no increased risk of any pregnancy problems following COVID vaccination... 1/

@DrAseemMalhotra But the study he is talking about has been preprinted, so we can take a look right now... 2/

preprints.org/manuscript/202…
@DrAseemMalhotra As the author said, he aims to compare the number of reports in VAERS for flu vaccines, from 1998 onwards, to those for COVID vaccines, from 2021 onwards.

This assumes that the rates of reporting over those periods are comparable, as the authors acknowledge in the preprint. 3/
Read 10 tweets
Viki Male Profile picture
Oct 29, 2022
@DarrellSpins That’s a good question. For increased cycle length, we can make two observations:

1. People on combined hormonal contraception are less likely to experience this

1/
frontiersin.org/articles/10.33…

medrxiv.org/content/10.110…
@DarrellSpins 2. People vaccinated early in their cycle are more likely to notice an effect.

2/
medrxiv.org/content/10.110…
@DarrellSpins Both these observations suggest a temporary effect of the innate (first phase) immune response on the hormones that drive the cycle. 3/
Read 7 tweets
Viki Male Profile picture
Oct 4, 2022
Just out! A new meta-analysis of 81,349 ppl receiving #CovidVaccine during #pregnancy compared to 255,346 unvaccinated. Vaccination...

👉🏻 Protects against infection

👉🏻 Lowers chance of stillbirth by 27%

👉🏻 Lowers chance of babies needing NICU by 12%

jamanetwork.com/journals/jamap…
I’ve been asked for some additional context around whether the 27% reduction in stillbirth reported by this paper is likely to be an overestimate…

🧵
This is particularly worth considering because a similar meta-analysis found that the rate of stillbirth was reduced by 15% among those vaccinated in pregnancy - rather less than the 27% reported here… 2/

nature.com/articles/s4146…
Read 11 tweets
Viki Male Profile picture
Sep 28, 2022
19,622 ppl tracking #periods, of whom 14,936 receive #CovidVaccine

👉🏻 Dose 1 associated with a 0.7d delay to the next period

👉🏻 Dose 2: 0.6d delay

👉🏻 2x doses in one cycle: 3.91d delay

👉🏻 Back to normal next cycle

👉🏻No change to period length

🧵…

bmjmedicine.bmj.com/content/1/1/e0…
We see these effects with all types of COVID vaccine (mRNA, adenovirus, inactivated virus), suggesting this is likely to be a result of the innate immune response – akin to side effects such as sore arm and fatigue – rather than an effect of any particular vaccine component. 2/
This is in line with previous reports on COVID vaccines, as well as some old reports from other types of vaccine. 3/

theguardian.com/commentisfree/…
Read 10 tweets
Viki Male Profile picture
Sep 27, 2022
This study looked at #breastmilk after #CovidVaccination in 11 people.

👉🏻 mRNA detectable in whole milk of 3 of them

👉🏻 Maximum concentration 0.1 parts per billion

👉🏻 This is roughly equivalent to a single tear in an Olympic pool

1/
jamanetwork.com/journals/jamap…
The findings are roughly in line with two previous studies which concentrated breast milk in order to detect very low quantities of vaccine mRNA (in fact, this one finds a little less). Low et al... 2/

And Yeo et al... 3/

ncbi.nlm.nih.gov/pmc/articles/P…
Read 11 tweets

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