@VikiLovesFACS @MarchandSurgery @drdrew 1/ I am going to retweet this, just an FYI. For posterity.
"Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression"
@Jikkyleaks
EMA has admitted non coding RNAs exist in the RNA ""vaccines". These are TGA.
ncbi.nlm.nih.gov/pmc/articles/P…
"Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression"
@Jikkyleaks
EMA has admitted non coding RNAs exist in the RNA ""vaccines". These are TGA.
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 2/ I can post more studies.
As I posted in anther thread under one of these videos,we have the regulatory lord and master of the UK medicine division, which is pro vaccine and pro RNA (and pro lockdown), that there are noncoding fragments in the vaccine. So that is proven.
As I posted in anther thread under one of these videos,we have the regulatory lord and master of the UK medicine division, which is pro vaccine and pro RNA (and pro lockdown), that there are noncoding fragments in the vaccine. So that is proven.
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 3/ that study I just posted about the fragments, come from plants! We are not even in vaccine world yet! I just posted about a plant. The kind that you eat!
Here is the full report right from the UK website and again, this is not up for debate. ema.europa.eu/en/documents/a…
Here is the full report right from the UK website and again, this is not up for debate. ema.europa.eu/en/documents/a…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 4/ When the EMA (that is the king--that is sovereign) which are pro vaccine, tells you, fragments are in there, that should be considered gospel. This one gets carved in stone now. Fragments verified of RNA via both EMA and TGA.
Whole RNA and LNP--considering it's been my job..
Whole RNA and LNP--considering it's been my job..
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 5/ Here is one (there is more) on covid infection before we dive into RNA and lipid nanoparticle and what the LNP can cross (everything).
"SARS-CoV-2 – the virus causing Covid-19 – can infect cells of the human placenta"
swissinfo.ch/eng/sci-tech/s…
"SARS-CoV-2 – the virus causing Covid-19 – can infect cells of the human placenta"
swissinfo.ch/eng/sci-tech/s…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 6/ I believe Google has removed many studies. Thankfully, I have academic access. :) I do more than listed in my bio. Many doctors state RNA and LNP do not cross the placenta.
I debated if effective to post one study, or to post more.
For effect, I must post all of them.
I debated if effective to post one study, or to post more.
For effect, I must post all of them.
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 7. Here we go. A lot of medical people think because they are doctors they know biotech, and I keep seeing errors made. And I have offered to teach, to go on podcasts, to share--I even said tonight one of the main companies I worked with on air! (I didn't violate NDA). And I get
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 8/ refused. I get told I am wrong. I am getting tired. I am the designer start to finish. Not a pipetter. Not a receptionist. My employment can be verified--I offer direct phone number and contacts if asked by podcasters. Now, back to RNA. The lipid nanoparticle is unstoppable.
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 9/ Now covid "vaccines" use RNA and LNP and therefor, are functional like any other LNP with RNA with similar formulation of LNP.
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy"pubs.acs.org/doi/10.1021/ja…
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy"pubs.acs.org/doi/10.1021/ja…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 10/ I also believe I deserve apologies for how some have treated me.
In the words of Benedict Cumberbatch, because I like humor, "Shall we begin?"
"Transport of Nanoparticles through the Placental Barrier"
The word "toxic" is used. Ouch.
jstage.jst.go.jp/article/tjem/2…
In the words of Benedict Cumberbatch, because I like humor, "Shall we begin?"
"Transport of Nanoparticles through the Placental Barrier"
The word "toxic" is used. Ouch.
jstage.jst.go.jp/article/tjem/2…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 11/ "Nanoparticulate Drug Delivery in Pregnancy: Placental Passage and Fetal Exposure"
researchgate.net/publication/49…
researchgate.net/publication/49…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 12/ *𝘸𝘩𝘪𝘴𝘵𝘭𝘦𝘴 𝘴𝘵𝘢𝘳 𝘵𝘳𝘦𝘬 𝘮𝘢𝘪𝘯 𝘵𝘩𝘦𝘮𝘦 𝘴𝘰𝘯𝘨*
"Lipid Nanoparticle Composition Drives mRNA Delivery to the Placenta"
pubmed.ncbi.nlm.nih.gov/36597546/
"Lipid Nanoparticle Composition Drives mRNA Delivery to the Placenta"
pubmed.ncbi.nlm.nih.gov/36597546/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 13/
"Nanoparticles can cross mouse placenta and induce trophoblast apoptosis"
I had to look up what trophoblast apoptosis means.
This one is not a regular lipid so I suppose, not really fair.
sciencedirect.com/science/articl…
"Nanoparticles can cross mouse placenta and induce trophoblast apoptosis"
I had to look up what trophoblast apoptosis means.
This one is not a regular lipid so I suppose, not really fair.
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 14/This one is not very forgiving. not at all.
"Preclinical and Clinical Safety Studies on DNA Vaccines"
Granted DNA, LNP is used.
tandfonline.com/doi/epdf/10.41…
"Preclinical and Clinical Safety Studies on DNA Vaccines"
Granted DNA, LNP is used.
tandfonline.com/doi/epdf/10.41…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 15/ right now we are not establishing toxicity (we can do that too). we are establishing that the many studies I will post, a measly person who does not have AN MD, treated as gum on shoe, who only manages these things day in and day out not worthy and knows nothing, knows a lot
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 16/ Hey guess what: ask me if I ever was asked to design a study for in utero delivery of RNA.
(yes)
Also, one project I did is in stage three clinical right now (its actually doing good things).
"Ionizable lipid nanoparticles for in utero mRNA delivery"
science.org/doi/10.1126/sc…
(yes)
Also, one project I did is in stage three clinical right now (its actually doing good things).
"Ionizable lipid nanoparticles for in utero mRNA delivery"
science.org/doi/10.1126/sc…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 18/ that says fetal above (fetus). And LNP. Lipid nanoparticle. Driving RNA into fetus.
Here is another. "Fetal gene therapy for neurodegenerative disease of infants"
Hannibal from the new A Team said that "Overkill is underrated".
pubmed.ncbi.nlm.nih.gov/30013199/
Here is another. "Fetal gene therapy for neurodegenerative disease of infants"
Hannibal from the new A Team said that "Overkill is underrated".
pubmed.ncbi.nlm.nih.gov/30013199/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 19/ "Gene therapy in mouse fetuses treats deadly disease"
pubmed.ncbi.nlm.nih.gov/30018442/
pubmed.ncbi.nlm.nih.gov/30018442/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 20/ Yeehaw. Via LNP "In utero gene editing for monogenic lung disease"
pubmed.ncbi.nlm.nih.gov/30996081/
pubmed.ncbi.nlm.nih.gov/30996081/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 21/ ":Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
pubmed.ncbi.nlm.nih.gov/34742747/
pubmed.ncbi.nlm.nih.gov/34742747/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 22/ "In utero nanoparticle delivery for site-specific genome editing"
pubmed.ncbi.nlm.nih.gov/29946143/
How can I, a nothing ness person in biotech, come up with all of this stuff
pubmed.ncbi.nlm.nih.gov/29946143/
How can I, a nothing ness person in biotech, come up with all of this stuff
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 23/ I have gotten so much grief from many for being a biotech manager and not a doctor and told that I know nothing, I have reached that point.
"In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery"
pubmed.ncbi.nlm.nih.gov/27782131/
"In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery"
pubmed.ncbi.nlm.nih.gov/27782131/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 24/ "Engineered nanomaterial applications in perinatal therapeutics"
And remember, we are just establishing that the LNP and RNA cross the placenta, because it was stated, they do not. I can post 100 of these.
I am not kidding.
Over 100 exist.
pubmed.ncbi.nlm.nih.gov/29477479/
And remember, we are just establishing that the LNP and RNA cross the placenta, because it was stated, they do not. I can post 100 of these.
I am not kidding.
Over 100 exist.
pubmed.ncbi.nlm.nih.gov/29477479/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 25/ yikes on bikes. This does not look healthy. "Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome"
pubmed.ncbi.nlm.nih.gov/29321036/
pubmed.ncbi.nlm.nih.gov/29321036/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 26/ "How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets"
pubmed.ncbi.nlm.nih.gov/34893164/
pubmed.ncbi.nlm.nih.gov/34893164/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 27/ Nanoparticles can cross the placenta during pregnancy, potentially exposing fetus
Date:
April 20, 2022
These are not even in the jabs. Just talking about regular old nanoparticles. sciencedaily.com/releases/2022/…
Date:
April 20, 2022
These are not even in the jabs. Just talking about regular old nanoparticles. sciencedaily.com/releases/2022/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 28/ "Targeted nanoparticles in pregnancy: a new
frontier in perinatal therapeutics"
ajog.org/article/S0002-…
frontier in perinatal therapeutics"
ajog.org/article/S0002-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 29/ Just a little break from the pregnancy--proving they cross the blood brain barrier (probably 100 of these too)
"Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma."
x-mol.net/paper/article/…
"Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma."
x-mol.net/paper/article/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 30/ I have neve done a thread this long.
"Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications"
ncbi.nlm.nih.gov/pmc/articles/P…
"Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications"
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 31/ "Exploiting the placenta for nanoparticle-mediated drug delivery
during pregnancy"
mitchell-lab.seas.upenn.edu/wp-content/upl…
during pregnancy"
mitchell-lab.seas.upenn.edu/wp-content/upl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 32/ Heyo!
". In pregnancy, nanoparticle-based drug formulations could have the potential to selectively target either the placenta and/or fetus, enabling ‘fetal-friendly’ drugs to be administered in pregnancy"
This was 2015. We are already there. futuremedicine.com/doi/10.2217/nn…
". In pregnancy, nanoparticle-based drug formulations could have the potential to selectively target either the placenta and/or fetus, enabling ‘fetal-friendly’ drugs to be administered in pregnancy"
This was 2015. We are already there. futuremedicine.com/doi/10.2217/nn…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 33/ "Design of nanomaterials for applications in maternal/fetal medicine"
pubs.rsc.org/en/content/art…
pubs.rsc.org/en/content/art…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 34/ These are all unique, individual studies. "Engineered nanomaterial applications in perinatal therapeutics"
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 35/ Ohhhhhhhhhhhh
"Finally, in utero administration of lipid nanoparticle–mRNA formulations can be applied to deliver mRNA to mouse fetuses achieving protein expression in fetal livers, lungs and intestines"
Like, spike protein?
nature.com/articles/s4157…
"Finally, in utero administration of lipid nanoparticle–mRNA formulations can be applied to deliver mRNA to mouse fetuses achieving protein expression in fetal livers, lungs and intestines"
Like, spike protein?
nature.com/articles/s4157…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 36/ "Non-viral gene editing in utero with lipid nanoparticles complexed to mRNA"
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 37/ Wowsers
"Researchers identify nanoparticles that could deliver therapeutic mRNA before birth"
phys.org/news/2021-01-n…
"Researchers identify nanoparticles that could deliver therapeutic mRNA before birth"
phys.org/news/2021-01-n…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 38/ I am mining for at least 50. That should break a record.
"Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery"
sciencedirect.com/science/articl…
"Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery"
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 39/
"PEDIATRIC SURGERY
Ionizable Lipid Nanoparticle Platforms for in Utero Drug Delivery"
journals.lww.com/journalacs/Cit…
"PEDIATRIC SURGERY
Ionizable Lipid Nanoparticle Platforms for in Utero Drug Delivery"
journals.lww.com/journalacs/Cit…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 40/
2023 baby! Woohoo!
"Lipid nanoparticle structure and delivery route during pregnancy dictates mRNA potency, immunogenicity, and health in the mother and offspring"
biorxiv.org/content/10.110…
2023 baby! Woohoo!
"Lipid nanoparticle structure and delivery route during pregnancy dictates mRNA potency, immunogenicity, and health in the mother and offspring"
biorxiv.org/content/10.110…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 41/
I am tired.
Holy chite.
"in vivo base editing or direct gene engineering on zygotes"
Base editing via LNP on zygotes. Sounds like the CRISPR babies.
science.org/doi/10.1126/sc…
I am tired.
Holy chite.
"in vivo base editing or direct gene engineering on zygotes"
Base editing via LNP on zygotes. Sounds like the CRISPR babies.
science.org/doi/10.1126/sc…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 42/ this one is 214 pages. 214 pages.
"Development of nanocarriers for
targeted drug delivery to the
placenta
"
University of Manchester
pure.manchester.ac.uk/ws/portalfiles…
"Development of nanocarriers for
targeted drug delivery to the
placenta
"
University of Manchester
pure.manchester.ac.uk/ws/portalfiles…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 43/
Sadly, science direct is having some issues loading tonight. Maybe because I am crashing it, heehee.
"Research on nanoparticles in human perfused placenta: State of the art and perspectives"
sciencedirect.com/science/articl…
Sadly, science direct is having some issues loading tonight. Maybe because I am crashing it, heehee.
"Research on nanoparticles in human perfused placenta: State of the art and perspectives"
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 44/
"In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles"
sciencedirect.com/science/articl…
"In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles"
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 45/ Did we do this one yet So far I have them all labeled as unique and no repeats.
#placentagate
"Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy"
pubs.acs.org/doi/abs/10.102…
#placentagate
"Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy"
pubs.acs.org/doi/abs/10.102…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 46/ "Exploiting the placenta..."
That's a statement.
"Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy"
#placentagate
sciencedirect.com/science/articl…
That's a statement.
"Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy"
#placentagate
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 47/
Of course this was already known back in Zika days.
A new extracellular vesicle delivered drug treatment can cross the placenta
exosome-rna.com/a-new-extracel…
Of course this was already known back in Zika days.
A new extracellular vesicle delivered drug treatment can cross the placenta
exosome-rna.com/a-new-extracel…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 48/ Teratogen in the womb is no joke. I have a lot of developmental classes under my belt. :)
F#CK YES my friends! F#ck yes!
@Jikkyleaks
#placentagate
"Potential preeclampsia treatment uses LNPs to deliver mRNA to the placenta"
2023 baby!
fiercebiotech.com/research/poten…
F#CK YES my friends! F#ck yes!
@Jikkyleaks
#placentagate
"Potential preeclampsia treatment uses LNPs to deliver mRNA to the placenta"
2023 baby!
fiercebiotech.com/research/poten…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 49. So someone tell them my background. More than biotech. Heehee
Use of RNA Interference by In Utero Electroporation to Study Cortical Development: The Example of the Doublecortin Superfamily
mdpi.com/2073-4425/3/4/…
Use of RNA Interference by In Utero Electroporation to Study Cortical Development: The Example of the Doublecortin Superfamily
mdpi.com/2073-4425/3/4/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 50/
50! This has to be one of the longest threads ever. Sorry Dr Drew, but I am trying to prove this point.
Nanoparticles to treat genetic diseases in utero
biotechscope.com/nanoparticles-…
50! This has to be one of the longest threads ever. Sorry Dr Drew, but I am trying to prove this point.
Nanoparticles to treat genetic diseases in utero
biotechscope.com/nanoparticles-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 51/
I don't know if I am gonna make 100, but I shall try. Eff sleep. Worth it.
Use of RNA Interference by In Utero Electroporation to Study Cortical Development: The Example of the Doublecortin Superfamily
ncbi.nlm.nih.gov/pmc/articles/P…
I don't know if I am gonna make 100, but I shall try. Eff sleep. Worth it.
Use of RNA Interference by In Utero Electroporation to Study Cortical Development: The Example of the Doublecortin Superfamily
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 52/
mRNA in utero, kids.
researchgate.net/figure/LNPs-de…
mRNA in utero, kids.
researchgate.net/figure/LNPs-de…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 53/In Utero Gene Therapy
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 54/
Clinical trial on LNP and pregnancy
"Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
clinicaltrials.gov/ct2/show/NCT05…
Clinical trial on LNP and pregnancy
"Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
clinicaltrials.gov/ct2/show/NCT05…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 55/
ooops
2018
"Potential adverse effects of nanoparticles on the reproductive system"
ncbi.nlm.nih.gov/pmc/articles/P…
ooops
2018
"Potential adverse effects of nanoparticles on the reproductive system"
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 56/
Break time, because I have designed this stuff, and THIS IS what it was designed for, not high throughput processes. It is for those who are suffering greatly, not the planet as a prophylactic. You should see the one I did for kids. fda.gov/news-events/pr…
Break time, because I have designed this stuff, and THIS IS what it was designed for, not high throughput processes. It is for those who are suffering greatly, not the planet as a prophylactic. You should see the one I did for kids. fda.gov/news-events/pr…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 57/
You betcha
"Nanoparticles Can Cross the Placenta During Pregnancy, Potentially Exposing Fetus"
rutgers.edu/news/nanoparti…
You betcha
"Nanoparticles Can Cross the Placenta During Pregnancy, Potentially Exposing Fetus"
rutgers.edu/news/nanoparti…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 58/
"CHOP and Penn Researchers Identify Nanoparticles that Could Be Used in Therapeutic mRNA Delivery before Birth"
chop.edu/news/chop-and-…
"CHOP and Penn Researchers Identify Nanoparticles that Could Be Used in Therapeutic mRNA Delivery before Birth"
chop.edu/news/chop-and-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 59/
"In-Utero Neurotoxicity of Nanoparticles"
#placentagate
2021!
intechopen.com/chapters/79886
"In-Utero Neurotoxicity of Nanoparticles"
#placentagate
2021!
intechopen.com/chapters/79886
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 60/
dude
it's even on their website
precisionnanosystems.com
dude
it's even on their website
precisionnanosystems.com
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 61/
Whoa. What is Clean Cap? Interesting. In Utero Delivery of CleanCap® mRNAs Using Ionizable Lipid Nanoparticles
trilinkbiotech.com/blog/in-utero-…
Whoa. What is Clean Cap? Interesting. In Utero Delivery of CleanCap® mRNAs Using Ionizable Lipid Nanoparticles
trilinkbiotech.com/blog/in-utero-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 63/
Kevin brought this up on the podcast we were on together last night, and I thought it interesting: This is for funsies. Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
ncbi.nlm.nih.gov/pmc/articles/P…
Kevin brought this up on the podcast we were on together last night, and I thought it interesting: This is for funsies. Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 64/ how cool is it when you are on a podcast, and you're talking about free floating bits of RNA in the mom from the baby? That doesn't happen every day!
Anyways...
"Exclusion of Reproductive-aged Women in COVID-19
Vaccination and Clinical Trials"
whijournal.com/article/S1049-…
Anyways...
"Exclusion of Reproductive-aged Women in COVID-19
Vaccination and Clinical Trials"
whijournal.com/article/S1049-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 65/ "
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease"
NOw this is something I know about. Homologous repair. KNockout. Different guides do not always work with different Cas9 from diff companies. cell.com/molecular-ther…
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease"
NOw this is something I know about. Homologous repair. KNockout. Different guides do not always work with different Cas9 from diff companies. cell.com/molecular-ther…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 66/ ask me why guide RNA matters from what company sometime for cas9 editing.
(or cas13)
How interesting is this???? Now doctors are linking infection to disease, even doing a three million dollar trial. And yet...elifesciences.org/articles/58716
(or cas13)
How interesting is this???? Now doctors are linking infection to disease, even doing a three million dollar trial. And yet...elifesciences.org/articles/58716
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 67/
I am so wiped out!
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
jci.org/articles/view/…
I am so wiped out!
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
jci.org/articles/view/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 68/
Intrauterine Fetal Gene Therapy: Is That the Future and Is That Future Now?
ncbi.nlm.nih.gov/pmc/articles/P…
Intrauterine Fetal Gene Therapy: Is That the Future and Is That Future Now?
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 69/
Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
ucsf.edu/news/2022/11/4…
Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
ucsf.edu/news/2022/11/4…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 70/
I feel as I am turning into veal at my desk.
Tin Man?
ojrd.biomedcentral.com/articles/10.11…
I feel as I am turning into veal at my desk.
Tin Man?
ojrd.biomedcentral.com/articles/10.11…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 71/
Delivery technologies for in utero gene therapy
mitchell-lab.seas.upenn.edu/wp-content/upl…
Delivery technologies for in utero gene therapy
mitchell-lab.seas.upenn.edu/wp-content/upl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 72/
An introduction to gene therapy and its potential prenatal use
obgyn.onlinelibrary.wiley.com/doi/full/10.10…
An introduction to gene therapy and its potential prenatal use
obgyn.onlinelibrary.wiley.com/doi/full/10.10…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 73/
"Study links small RNA molecule to pregnancy complication"
@Jikkyleaks
sciencedaily.com/releases/2016/…
#placentagate
"Study links small RNA molecule to pregnancy complication"
@Jikkyleaks
sciencedaily.com/releases/2016/…
#placentagate
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 74/
Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications
hindawi.com/journals/jp/20…
Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications
hindawi.com/journals/jp/20…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 75/
Association of Polymorphisms in the Long Non-Coding RNA HOTAIR with Recurrent Pregnancy Loss in a Korean Population
mdpi.com/2073-4425/13/1…
Association of Polymorphisms in the Long Non-Coding RNA HOTAIR with Recurrent Pregnancy Loss in a Korean Population
mdpi.com/2073-4425/13/1…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 76/
And now for something different, similar theme
nytimes.com/2021/12/13/hea…
And now for something different, similar theme
nytimes.com/2021/12/13/hea…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 78/
Multifunctional nanoparticles for real-time evaluation of toxicity during fetal development
journals.plos.org/plosone/articl…
Multifunctional nanoparticles for real-time evaluation of toxicity during fetal development
journals.plos.org/plosone/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 79/
Nanoparticles induced embryo–fetal toxicity
journals.sagepub.com/doi/abs/10.117…
Nanoparticles induced embryo–fetal toxicity
journals.sagepub.com/doi/abs/10.117…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 80/
Im too old to stay up this late
yucko
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic
mRNA delivery
mitchell-lab.seas.upenn.edu/wp-content/upl…
Im too old to stay up this late
yucko
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic
mRNA delivery
mitchell-lab.seas.upenn.edu/wp-content/upl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 81/ 3 am. 2 more hours mark 24 hr awake
news-medical.net/news/20230216/…
news-medical.net/news/20230216/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 82/
"stabilized lipid nanoparticles for in utero intra-amniotic mRNA"
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
discovery.researcher.life/article/nanopa…
"stabilized lipid nanoparticles for in utero intra-amniotic mRNA"
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
discovery.researcher.life/article/nanopa…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 83/
Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy
pci.testtechnologypublisher.com/?Test_Inteum_T…
Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy
pci.testtechnologypublisher.com/?Test_Inteum_T…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 84/
IN UTERO
Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma
jitc.bmj.com/content/6/1/125
IN UTERO
Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma
jitc.bmj.com/content/6/1/125
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 85/
In utero LNP patent
Cool
patents.google.com/patent/WO20200…
In utero LNP patent
Cool
patents.google.com/patent/WO20200…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 86/
I am definitely veal now at desk
Not to be confused with vale
Another in utero
dan-peer.tau.ac.il/wp-content/upl…
I am definitely veal now at desk
Not to be confused with vale
Another in utero
dan-peer.tau.ac.il/wp-content/upl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 87/
in utero as well
Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases
frontiersin.org/articles/10.33…
in utero as well
Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases
frontiersin.org/articles/10.33…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 91/
A little late, I would say. To Evaluate the Safety, Tolerability, and Immunogenicity of BNT162b2 Against COVID-19 in Healthy Pregnant Women 18 Years of Age and Older
clinicaltrials.gov/ct2/show/NCT04…
A little late, I would say. To Evaluate the Safety, Tolerability, and Immunogenicity of BNT162b2 Against COVID-19 in Healthy Pregnant Women 18 Years of Age and Older
clinicaltrials.gov/ct2/show/NCT04…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 92/
Did we do this one yet? Fetotoxicity of Nanoparticles: Causes and Mechanisms
ncbi.nlm.nih.gov/pmc/articles/P…
Did we do this one yet? Fetotoxicity of Nanoparticles: Causes and Mechanisms
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 93/
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials
in utero
…eandfibretoxicology.biomedcentral.com/articles/10.11…
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials
in utero
…eandfibretoxicology.biomedcentral.com/articles/10.11…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 94/
In utero transmission reported.
Yes. mdpi.com/1422-0067/24/3…
In utero transmission reported.
Yes. mdpi.com/1422-0067/24/3…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 95/
A popular one. No bueno
Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey
journals.sagepub.com/doi/full/10.11…
A popular one. No bueno
Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey
journals.sagepub.com/doi/full/10.11…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 96/
in utero
4 more!
Lipid nanoparticles for mRNA delivery
theconferenceforum.org/wp-content/upl…
in utero
4 more!
Lipid nanoparticles for mRNA delivery
theconferenceforum.org/wp-content/upl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 97/
a chite ton all in one page in utero is in there
scholar.google.com/citations?user…
a chite ton all in one page in utero is in there
scholar.google.com/citations?user…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 98/
Precision nano again! In utero baby! Pun intended!
precisionnanosystems.com/news-room/deta…
Precision nano again! In utero baby! Pun intended!
precisionnanosystems.com/news-room/deta…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 99/
In utero LNP in mice.
mhlw-grants.niph.go.jp/system/files/2…
In utero LNP in mice.
mhlw-grants.niph.go.jp/system/files/2…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 100/
In utero LNP trials tn.linkedin.com/posts/myles-ve…
In utero LNP trials tn.linkedin.com/posts/myles-ve…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 101/
𝓫𝓮𝓬𝓪𝓾𝓼𝓮 𝓘 𝓬𝓪𝓷 𝓪𝓷𝓭 𝓽𝓱𝓲𝓼 𝓯𝓮𝓮𝓵𝓼 𝓮𝓹𝓲𝓬 𝓽𝓸 𝓶𝓮 𝓷𝓸𝔀
RNA and LNP in utero aspirushealthplan.com/webdocs/60040-…
𝓫𝓮𝓬𝓪𝓾𝓼𝓮 𝓘 𝓬𝓪𝓷 𝓪𝓷𝓭 𝓽𝓱𝓲𝓼 𝓯𝓮𝓮𝓵𝓼 𝓮𝓹𝓲𝓬 𝓽𝓸 𝓶𝓮 𝓷𝓸𝔀
RNA and LNP in utero aspirushealthplan.com/webdocs/60040-…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 102/
in utero LNP (before birth)
nanomedicines.ca/lrd-2022-progr…
in utero LNP (before birth)
nanomedicines.ca/lrd-2022-progr…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 104/
UC Davis Health to develop in-utero therapy for Duchenne
LNP
health.ucdavis.edu/news/headlines…
UC Davis Health to develop in-utero therapy for Duchenne
LNP
health.ucdavis.edu/news/headlines…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 105/
yes it says in utero kids
sabinopaciolla.com/risposta-immun…
yes it says in utero kids
sabinopaciolla.com/risposta-immun…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 106/
in utero delivery
blog.seas.upenn.edu/new-lipid-nano…
in utero delivery
blog.seas.upenn.edu/new-lipid-nano…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 107/
Prenatal Gene Therapy for Metabolic Disorders
ncbi.nlm.nih.gov/pmc/articles/P…
Prenatal Gene Therapy for Metabolic Disorders
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 108/
Bonus round: we know there is ethanol present in the RNA "vaccines" because that is used in the self construction of the LNP.
In Utero Exposure to Ethanol Alters mRNA for Insulin-Like Growth Factors
academia.edu/21835778/In_Ut…
Bonus round: we know there is ethanol present in the RNA "vaccines" because that is used in the self construction of the LNP.
In Utero Exposure to Ethanol Alters mRNA for Insulin-Like Growth Factors
academia.edu/21835778/In_Ut…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 109/ n Utero gene therapy: current challenges and perspectives
I have not even entered the nanotechnology journals yet.
Let that sink in
cell.com/molecular-ther…
I have not even entered the nanotechnology journals yet.
Let that sink in
cell.com/molecular-ther…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 11/
The fetal treatment center! Video! in utero use of LNP and RNA!
The fetal treatment center! Video! in utero use of LNP and RNA!
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 112/
now we are going to what appears to be dark places
Experimental models of maternal-fetal interface and their potential use for nanotechnology applications
pubmed.ncbi.nlm.nih.gov/31469205/
now we are going to what appears to be dark places
Experimental models of maternal-fetal interface and their potential use for nanotechnology applications
pubmed.ncbi.nlm.nih.gov/31469205/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 113/
Now this is interesting. Really. New research uses nanotechnology to prevent preterm birth
sciencedaily.com/releases/2016/…
Now this is interesting. Really. New research uses nanotechnology to prevent preterm birth
sciencedaily.com/releases/2016/…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 114/
ooofda!
Nanoparticles versus the placenta
nature.com/articles/nnano…
ooofda!
Nanoparticles versus the placenta
nature.com/articles/nnano…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 115/
New Research Uses Nanotechnology to Prevent Preterm Birth
wow ow
I have my own doc appt in a couple of hours. LOL no sleep
marchofdimes.org/about/news/new…
New Research Uses Nanotechnology to Prevent Preterm Birth
wow ow
I have my own doc appt in a couple of hours. LOL no sleep
marchofdimes.org/about/news/new…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 116/
Current understanding of the toxicological risk posed to the fetus following maternal exposure to nanoparticles
pubmed.ncbi.nlm.nih.gov/29086601/
Current understanding of the toxicological risk posed to the fetus following maternal exposure to nanoparticles
pubmed.ncbi.nlm.nih.gov/29086601/
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 117/
A Review of Nanotechnology for Treating Dysfunctional Placenta
frontiersin.org/articles/10.33…
A Review of Nanotechnology for Treating Dysfunctional Placenta
frontiersin.org/articles/10.33…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 118/
Nanoparticles can cross the placenta during pregnancy, potentially exposing fetus
@Jikkyleaks
#placentagate
nanowerk.com/nanotechnology…
Nanoparticles can cross the placenta during pregnancy, potentially exposing fetus
@Jikkyleaks
#placentagate
nanowerk.com/nanotechnology…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 119/
Le sigh
Nanotechnology in reproductive medicine: Emerging applications of nanomaterials
sciencedirect.com/science/articl…
Le sigh
Nanotechnology in reproductive medicine: Emerging applications of nanomaterials
sciencedirect.com/science/articl…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 120/
yewp
patially deliver drugs and retain them at the targeted site, pregnancy still represents a challenge
ncbi.nlm.nih.gov/pmc/articles/P…
yewp
patially deliver drugs and retain them at the targeted site, pregnancy still represents a challenge
ncbi.nlm.nih.gov/pmc/articles/P…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 121/
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
academic.oup.com/humupd/article…
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
academic.oup.com/humupd/article…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks 122/
I could keep going and post another 100.
So, over 100 unique studies
It crosses the placenta
But that is not all
#placentagate
Targeted Nanoparticle Delivery For In Uter or In Utero Treatment Of
Congenital Disorders
elischolar.library.yale.edu/cgi/viewconten…
I could keep going and post another 100.
So, over 100 unique studies
It crosses the placenta
But that is not all
#placentagate
Targeted Nanoparticle Delivery For In Uter or In Utero Treatment Of
Congenital Disorders
elischolar.library.yale.edu/cgi/viewconten…
@VikiLovesFACS @MarchandSurgery @drdrew @Jikkyleaks @ABridgen
@SenatorRennick
Just in case you need 100+ studies on the RNA/LNP crossing the placenta, toxicity, etc.
@SenatorRennick
Just in case you need 100+ studies on the RNA/LNP crossing the placenta, toxicity, etc.
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