Thanks to Italy's press agency of pharmacists for publishing the research and advocacy note @MartaEsperti (@longcoviditalia) and I wrote on #LongCovid in occasion of #LongCovidAwarenessDay

rifday.it/2023/03/16/gio…
We underlined 15 March has been chosen by patients for patients to advocate for #LongCovidAwareness. We remembered Long Covid has been a term and a concept defined by patients from early 2020. We remembered the WHO recognized Long Covid in August 2020, and Italy in 2021
We underlined we have now a lot of scientific data on acute and #LongCovid (see PubMed). We noted Covid and Long Covid can basically hit all organs and body systems. We underlined the relapsing-remitting, sometimes progressive, and at times subclinical pathology in Long Covid
We underlined the need for striving for full social inclusion, a dignified life and care for all #LongCovid patients (in our note with a focus on Italy). We underlined the need for more research to fully elucidate the pathophysiology and find better treatments and a cure
Thanks to @LCawarenessInt for organising #LongCovidAwarenessDay #LongCovidAwarenessMonth #LongCovidAwareness and to the #LongCovid community to take part

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More from @elisaperego78

Mar 10
"We propose that SARS-CoV-2 ... threatens genome integrity and causes altered DNA damage response activation, induction of inflammation and cellular senescence"

"In addition to induce DNA damage, SARS-CoV-2 inhibits its repair"

nature.com/articles/s4155…
"In sum, our results obtained by different techniques and in three independent cell types indicate that SARS-CoV-2 infection causes DNA damage and an altered DDR; this is associated with the induction of pro-inflammatory pathways and cytokines and cellular senescence."
The study used different methods and samples to achieve its results, including analysis of human tissue from Covid patients and a "humanized" mice: "(our data were] observed in two immortal cell lines, in primary human cells and in vivo in mice and humans."
Read 5 tweets
Mar 9
"Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage"

Key clusters of genes impacted were uniquely altered by SARS-CoV-2 infection, and were distinct from pH1N1 (=2009 pandemic influenza)

onlinelibrary.wiley.com/doi/10.1111/im…
Small study, but interesting "we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches."
"In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. SARS-CoV-2 has been associated with acute and long-term cardiovascular disease"
Read 8 tweets
Mar 9
Endogenous Fungal Endophthalmitis (EFE) after COVID Hospitalization: evidence from a prolonged observational study of six patients (one died)

"EFE is a sight-threatening condition generally caused by fungemia and hematogenous seeding of fungal pathogens"

sciencedirect.com/science/articl…
The study involved six patients with severe acute Covid and prolonged hospitalization. Five males. All had commorbities (asthma, diabetes, hypertension or RA). Age ranged from 35 to 64. EFE manifested either in hospital or within 35 days post discharge. One had EFE in both eyes
Patiens had received dexamethasone and remdesivir during their COVID-related hospitalization. All presented with decreased vision, and 4/6 complained of floaters. [much more in depth description of symptoms, signs, and analysis done is in the paper for those interested]
Read 11 tweets
Mar 7
Covid—#LongCovid are already some of the most studied diseases in medical history. If you enter *Covid into the database for biomedical papers PubMed right now, you get 338,575 results. There is no excuse not to expedite more research, support and trials

pubmed.ncbi.nlm.nih.gov/?term=Covid
We have also a wide range, obviously! of pre existing research on a wide range of conditions found with Covid—#LongCovid from cardiovascular to neurological to viral-onset to metabolic and autoimmune diseases. Do we know everything about Covid? As I said many times before, no.
Do we know enough to try to give patients diagnostic and treatment for the issues we can at least treat? Yes, we do, including from patient-driven research done by many, who have been sharing their data and experiences on this platform since 2020—1 e.g.

mantovauno.it/salute/long-co…
Read 7 tweets
Mar 7
I've already tweeted about this a lot, but here we go again. We're on a de facto mass infection policy with an airborne, fast-evolving SARS virus, the risks of which were known about immediately. The evidence we uncovered in the last three years only incremented that knowledge
The developments of the last few months have been further concerning. There are countries and institutions planning to end the covid emergency, which still affords some protection to the population. We don't have clear plans forward about vaccination

nytimes.com/2023/01/30/us/…
Surveillance for SARS-CoV-2 is increasingly poor: many people have difficulties in accessing testing. Many don't report to authorities they home test results, or aren't testing because we're being told Covid isn't a big danger anymore. We're increasingly flying blind
Read 14 tweets
Mar 6
"Our mortality is out of this world because for weeks we have been unable to take care of patients properly ... Milan is risking an hecatomb [a slaughtering, a massacre]"

—message by an healthcare official, from 21 March 2020

(Italy's Covid enquiry)

milano.repubblica.it/cronaca/2023/0…
Translation to English and summary by myself. For the original message, as reported in Italian, please see the reporting I attached by a prominent Italian newspaper (La Repubblica).

milano.repubblica.it/cronaca/2023/0…
Milan, for those not familiar with Italy, is the main city of Lombardy, the early Covid epicenter outside China. Covid was first cataclysmic in smaller centres like Bergamo, Lodi, etc., but there was severe concern of unleashed spread in much bigger Milan

nytimes.com/2020/11/29/wor…
Read 4 tweets

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