🇮🇱 48,868 babies followed for first 120 days of life. Does being born after a #CovidVaccine booster in #pregnancy protect against hospitalisation for COVID?
👉🏻 Yes! With 53% effectiveness compared to two doses only.
👉🏻 Protection is greater when the booster dose is given later in pregnancy
👉🏻 Protection wanes as babies get older, with no significant protection after 90 days, in this study.
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A lot of parents and paediatricians have been in touch with me recently querying the policy of offering a booster as early as possible. Wouldn’t it be better to delay and maximise protection for babies? The authors have something to say here… 3/
The answer depends on the trade off between protection during pregnancy and protection of babies after they are born, and this may change as we move into an era where most people have been vaccinated and/or infected already. More to follow… 4/4
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@toadmeister Hi Toby! Our most up to date information on births and newly registered pregnancies in the NHS (to October 2022) shows no decline in either... 1/
@toadmeister It’s worth noting that the HES dataset, which you’re using there, isn’t yet finalised (though it will be shortly). So some births in the most recent months are not yet included in the dataset… but that doesn’t mean they didn’t happen. 2/
@DrAseemMalhotra Hi Aseem! It would be very surprising if this one study had really found what the author claims, given the overwhelming body of evidence now showing no increased risk of any pregnancy problems following COVID vaccination... 1/
@DrAseemMalhotra As the author said, he aims to compare the number of reports in VAERS for flu vaccines, from 1998 onwards, to those for COVID vaccines, from 2021 onwards.
This assumes that the rates of reporting over those periods are comparable, as the authors acknowledge in the preprint. 3/
This is particularly worth considering because a similar meta-analysis found that the rate of stillbirth was reduced by 15% among those vaccinated in pregnancy - rather less than the 27% reported here… 2/
We see these effects with all types of COVID vaccine (mRNA, adenovirus, inactivated virus), suggesting this is likely to be a result of the innate immune response – akin to side effects such as sore arm and fatigue – rather than an effect of any particular vaccine component. 2/
This is in line with previous reports on COVID vaccines, as well as some old reports from other types of vaccine. 3/