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Mar 26 • 9 tweets • 3 min read
Aerosol exposure of monkeys to #Marburg virus.

Experimental conditions. Uniformly fatal.

ncbi.nlm.nih.gov/pmc/articles/P…
“…however, for the 2 cases in tourists visiting Uganda in 2008, unprotected contact with infected bat feces or aerosols are the most likely routes of infection.”

cdc.gov/vhf/marburg/tr…
Archived. 🙄

web.archive.org/web/2023032608…
Another 15 monkeys successfully infected by MVD and then sacrificed.

journals.asm.org/doi/10.1128/JV…
One of the case studies of MVD.

4 miners that lived at a mining camp site and entered a bay colonised cave/mine.

Possible person to person transmission seen.

ncbi.nlm.nih.gov/pmc/articles/P…
Case 3 is interesting in that there is some documentation of what PPE was used by the nurse.

Two hours of exposure with no PPE. Thereafter “mask” unspecified and gloves/gown.

ncbi.nlm.nih.gov/pmc/articles/P…
Can Marburg transmit via aerosol? Definite yes under experimental conditions.

Can it do so in clinical care? I think it could be possible. Patients produce copious quantities of vomit stools etc. coughing up blood is a possibility…
It’s very hard to tease apart physical contact with things in close contact with the patient and close range, high quantity aerosol.

Anyone that doesn’t want to try out being one of the Macaques… should wear a respirator when caring for patients with the haemorrhagic fevers.
No. Aerosol transmission does not necessarily mean “spreads like covid/measles”…

I hope we can appreciate that aerosol spread may have different efficiencies depending on the pathogen.

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More from @NjbBari3

Dr Noor Bari Profile picture
Mar 28
I have never used a surgical mask for PPE in my entire 20 year career.
20+ years…
Ever…
Read 10 tweets
Dr Noor Bari Profile picture
Mar 28
Pox viruses are hardy in the environment and historically have been predominantly airborne.
So no, I’m not surprised this one is probably showing it’s wings…
Also. I told you so.
Read 5 tweets
Dr Noor Bari Profile picture
Mar 28
I spoke to an elder family member about what is happening to other young unvaccinated family members in England, as the COVID infections accumulate.

The constant sickness.

His response… it’s public health’s job to inform us. Why haven’t they informed us? @NSWCHO
Parents, and in this case grandparents deserve to know the truth about COVID infections in children. Particularly the unvaccinated youngest cohort.

This grandparent will chose to keep exposing this child… but I expect will also be very angry if COVID complications occur.
They genuinely think COVID is safe in childhood…

Is it? Really?
Read 5 tweets
Dr Noor Bari Profile picture
Mar 27
Neurodevelopment of male babies in utero.

#COVID

n=883
3% in group tested positive SARS-CoV-2

1.8% in group that did not test positive to SARS-CoV-2

(Comparison to precovid cohort.)

medscape.com/viewarticle/99… Image
After adjusting for factors…race, insurance, maternal age, and preterm birth, SARS-CoV-2 during pregnancy was  associated with an increased risk for neurodev. diagnoses at 12 months among boys (adjusted odds ratio [OR], 1.94; 95% CI, 1.12 - 3.17; P = .01), but not among girls.
Pre vaccination era, but that means that waning immunity on expectant mothers may be an issue.
Read 5 tweets
Dr Noor Bari Profile picture
Mar 26
A person came over to my checkout at the supermarket to reset it (because I am a technology gremlin)… coughed, sneezed without covering their nose or mouth, wiped their nose on the back of their hands, and then used that hand to handle everything…
I don’t normally wipe down my groceries, but I’m making an exception!
I feel so let down by public health. Where is the messaging?
Read 6 tweets
Dr Noor Bari Profile picture
Mar 24
At the end of two years of preclinical medicine, I would say I had a basic grasp of the fundamentals of science that underpins medicine.

Despite that, it was a gruelling two years, jam packed with info.
The three years of clinical medicine training was a whistle stop tour through all the branches of medicine. It barely gives you a chance to grasp the basics… only if you put in a lot of hours on the ward might you start to hone your ability to pick up clinical signs.
The first two years after graduating, you are like a learner driver. Wobbling about on shiny new but unsteady wheels. You need supervision to help prioritise the snowstorm of work and avoid pitfalls.
Read 6 tweets

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