4/ The interesting thing about his symptoms are that they're stereotyped. Most vascular events are not stereotyped, maybe you get events that localize to the same hemisphere or vascular territory, but the exact same events??
Arm exercise and then dizziness??
5/ Dopplers were ordered.
which demonstrate ⬇️
Uh oh, no flow past this occlusion in the L ICA!
6/ Contralaterally, things aren't really looking great either.
Thats a very tight stenosis of the R ICA.
7/ TCDs demonstrate intracranial collateralization through the AComm, with inverted flow in the L A1.
So the L anterior circulation is largely supplied by the R critically stenosed ICA.😱😱
8/ But…. The guy did not present with transient right arm weakness or aphasia- symptoms of poor perfusion to the left hemisphere
& while you could make a case for artery-to-arty embolization from the R ICA to the R hemisphere to explain the L arm parestheisas.... why recurrent?
9/ And why the dizziness?
The answer…?
Inverted flow in the left vertebral artery!! And bidirection flow in the proximal basilar.
10/ What was happening?
MRA (not published in the issue, so I borrowed an example from our friends @radiopaedia.) confirmed severe stenosis of the proximal subclavian. His symptoms?
A subclavian steal effect!
11/ If subclavian steal is confusing, I like this diagram.
All suggested by a simple non-invasive, radiation free workup.
Patient underwent smoking cessation, lipid control and revascularization.
12/ 12/ But wait!
There was one more thing!
Lets go back to the very first image... He had one more stroke risk factor.
Can you tell? (I know some of you probably did in the first poll!)
13/ Yes! An irregular heart rate suggestive of (EKG confirmed) occult a fib! All that. Just from ultrasound. Isn’t it amazing what neurosonography can do?!
2/ Also @CroninNeuro pointed out that high RoPE (>= 7) and PFO and you should close regardless thus no testing needed for FVL or PT gene mutation.
True! You could throw away all venous testing… closing a PFO in this situation is evidenced based regardless of test outcome.
3/ BUT, TBH, I think I might want to know if I were at potentially higher than average for benefit from closure since no procedure has zero risk...But, has not been looked at in any RCT!
Just another data for personalization, and these tests aren't
2/
A 41 yo M w/ history of testicular cancer presents with a vague headache & several days of fatigue. A few days after these vague symptoms began, he developed burning over with left abdomen and right retroauricular pain. A day later his wife points out that he’s drooling.
🤤
3/
🛑Pause Here! (the book instructs you to do so!) 🛑
Just as suggested by this awesome chart shared by @LyellJ & @mayoneurores, all neurologic diagnosis starts with determining the tempo and focal/diffuse