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Study discovers T cells in human blood secrete a substance that affects blood pressure and inflammation #POTS #LongCovid
medicalxpress.com/news/2023-03-c…
medicalxpress.com/news/2023-03-c…
medicalxpress.com/news/2023-03-c…
"Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear."
"Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear."
medicalxpress.com/news/2023-03-c…
"Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation."
"Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation."
medicalxpress.com/news/2023-03-c…
"The relative frequency of CD4+ ChAT+ T cells in blood correlated with survival."
"The relative frequency of CD4+ ChAT+ T cells in blood correlated with survival."
Cholinergic regulation of vascular endothelial function by human ChAT+ T cells
pnas.org/doi/10.1073/pn…
pnas.org/doi/10.1073/pn…
pnas.org/doi/10.1073/pn…
"ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined."
"ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined."
pnas.org/doi/10.1073/pn…
"T lymphocytes expressing choline acetyltransferase (ChAT), the enzyme catalyzing biosynthesis of the vasorelaxant acetylcholine (ACh), regulate vasodilation and are integral to the cholinergic antiinflammatory pathway in an inflammatory reflex in mice."
"T lymphocytes expressing choline acetyltransferase (ChAT), the enzyme catalyzing biosynthesis of the vasorelaxant acetylcholine (ACh), regulate vasodilation and are integral to the cholinergic antiinflammatory pathway in an inflammatory reflex in mice."
pnas.org/doi/10.1073/pn…
"Here, we found that human T cell ChAT mRNA expression was induced by T cell activation involving the PI3K signaling cascade."
"Here, we found that human T cell ChAT mRNA expression was induced by T cell activation involving the PI3K signaling cascade."
pnas.org/doi/10.1073/pn…
"Mechanistically, we identified that ChAT mRNA expression was induced following the attenuation of RE-1 Silencing Transcription factor REST-mediated methylation of the ChAT promoter,"
"Mechanistically, we identified that ChAT mRNA expression was induced following the attenuation of RE-1 Silencing Transcription factor REST-mediated methylation of the ChAT promoter,"
pnas.org/doi/10.1073/pn…
"and that ChAT mRNA expression levels were up-regulated by GATA3 in human T cells."
"and that ChAT mRNA expression levels were up-regulated by GATA3 in human T cells."
pnas.org/doi/10.1073/pn…
"In functional experiments, T cell-derived ACh increased endothelial nitric oxide-synthase activity, promoted vasorelaxation, and reduced vascular endothelial activation and promoted barrier integrity by a cholinergic mechanism."
"In functional experiments, T cell-derived ACh increased endothelial nitric oxide-synthase activity, promoted vasorelaxation, and reduced vascular endothelial activation and promoted barrier integrity by a cholinergic mechanism."
pnas.org/doi/10.1073/pn…
"Further, we observed that survival in a cohort of patients with severe circulatory failure correlated with their relative frequency of ChAT +CD4+ T cells in blood."
"Further, we observed that survival in a cohort of patients with severe circulatory failure correlated with their relative frequency of ChAT +CD4+ T cells in blood."
pnas.org/doi/10.1073/pn…
"These findings on ChAT+ human T cells provide a mechanism for cholinergic immune regulation of vascular endothelial function in human inflammation."
"These findings on ChAT+ human T cells provide a mechanism for cholinergic immune regulation of vascular endothelial function in human inflammation."
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