Paul Maidowski Profile picture
Apr 4 4 tweets 3 min read Twitter logo Read on Twitter
1. SARS associated neurocognitive disorder (SAND) in children

I’m glad to not work in a Kita (kindergarten) even though it’s a great job: this is where the early warning signals - SAND from serially infecting all children with a highly pathogenic SARS virus - will be seen first.
2. SAND owes to @dbdugger, who applies the lessons from 40 years of HIV science to SARS-CoV, a different but comparable virus. The equivalent to SAND is HIV associated neurocognitive disorder (HAND) - same mechanism, both have no cure even after 40 years.
3. Science is a team sport, politics doubly so. I’m willing to answer questions or pilot through the thicket of @RealCheckMarker threads on real public health solutions.

IF you want to think you or your kids can ‘live with’ COVID-19, you should probably stop reading now. #twKita
4. She tries to warn so we don’t repeat the errors of COVID-2003. As political scientist I add that it is up to leadership (legislative, executive) and the courts. That’s who you need to address.

But first, to be effective, you need to learn to protect your own families. #twKita

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More from @_ppmv

Apr 4
1. Dynamics of ZeroCovid policy #ZeroSARS #清零政策

Did it fail as China abandoned ZC policy? No.

A covid-conscious colleague calls me, concerned re conflict. They rightly observe conservative values match ZC:

Sanctity of life
National security
Sense of authority and hierarchy
2. I lost track of who follows me, beyond 1/3 climate, 1/3 SARS-health-systems, 1/3 dad jokes.

Yet this new follower somehow caught my eye.

Obvs conservatives are organizing to hold Biden and Democrats/liberals accountable for their horrific pandemic policy.

No surprise there.
3. Effective policy requires understanding the mechanics of SARS.

Transmission sustains the pandemic: "one ship every three months".

The ONLY way to eliminate SARS is to stop the ship before it leaves harbor. Before the virus gets on a plane on two legs.
Read 8 tweets
Apr 4
Wear a N95—and what eye protection?

Dräger x-pect 8510 here—type/model will depend on fit.

Feel free to share what works in your experience in everyday/work settings. We need to generate such knowledge ourselves as long as ppl are in "Don't stick out and live with Covid" mode.
Note: This is probably not ideal / doesn't provide airborne (just droplet) protection! Some learning ahead 😌
Read 6 tweets
Apr 4
The key subject in school?

Fun question, and I see @_david_ho_ & climate scientists mean well. You can have perfect understanding of physics, yet be clueless about how to change society. (Climate isn’t a physics problem.)

Most relevant is learning to think, i.e. the humanities.
Why is this relevant? We’ve been trying to get climate scientists - key messengers - to speak meaningfully about integrated systems problems for many years, mostly the unphysical (=sadly wrong) models of climate economics.

Hasn’t happened, so here we are.
You see, @_david_ho_ is right, thermodynamics matters. If this is in any way counterintuitive, continue reading.
Read 18 tweets
Apr 3
Political scientist here. Share this thread with scientists. Apply the lessons from 40 years of HIV medicine to SARS-CoV, a virus that establishes persistence (until apoptosis occurs) and knows no cellular-level sterilizing immunity. Elimination, effective policy, is the way out.
Why scientists? - The basics are still not widely understood. As politics remains dysfunctional, you need to organize and learn fast. Use system dynamics / systems analysis. SARS is not the shape of a policy problem that your conventional thinking can solve.
Why do you need political scientists on your teams? Look at the current mess after $ billions for biomed & 100,000s of papers*. We have no political goal or work programme to end the pandemic, in year Four!

* good, but low-leverage to systems scientists.
Read 4 tweets
Apr 2
1. How does SARS-CoV cause lymphopenia (~AIDS)?

This review article is from 2015, well before SARS-CoV-2 emerged. Still, it is far more accurate than 99% of COVID-19 discussion. Read carefully.

You can fool some people some of the time, but not nature. sciencedirect.com/science/articl… Image
2. "Unlike other RNA viruses, CoVs encode a 3′-5′ exonuclease that has *proofreading activities* [...]. CoVs are also capable of *genetic recombination* if two viruses infect the same cell at the same time.

That's what drives the pandemic yet you'll only hear it on twitter. lmao Image
3. "All CoVs develop exclusively in the cytoplasm of infected cells." SARS does NOT behave like influenza, which takes over the cell, and replicates until it explodes like a balloon. (SARS even EXTENDS its lifecycle.) Western intellectual laziness and hubris cost them the future. Image
Read 44 tweets
Apr 1
We mentioned this last year. @stkirsch is textbook case of bodyguard manipulation, a host helping SARS-CoV spread in the population.
#BlockDontMock. Don’t give them a platform to spread their hallucinations.
Read 4 tweets

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