@Twitter

@JAMA_current

This Thread may be Removed Anytime!

Twitter may remove this content at anytime! Save it as PDF for later use!

More from @DrDamluji

Abdulla A. Damluji, MD, PhD

@DrDamluji

Apr 4

@CircAHA

Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification: @CircAHA

Mechanistic study: Toll-Like Receptor 3 = TLR3

Here is few point summary

👇👇👇

1/ 🧪 This study identifies TLR3 as a key element in aortic valve calcification. BGN, a central component of the extra cellular matrix (ECM), induces the TLR3 signaling cascade, resulting in valvular interstitial cells (VICs) transforming into bone-forming osteoblast-like cells.

2/ 🔍 The study reveals the first direct interaction between BGN and TLR3 in the cell type primarily responsible for aortic valve calcification. This suggests that BGN may govern TLR3-dependent levels of basal type I interferons (IFN) in human fibroblasts.

Read 8 tweets

Abdulla A. Damluji, MD, PhD

@DrDamluji

Apr 3

@CircAHA

Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study: @CircAHA

5-point summary below: 👇👇

(1/5)

🚫 This trial is a single-arm, open label, phase IV clinical study that evaluated coronary atherosclerotic plaque regression with a PCSK9 inhibitor in asymptomatic patients with familial hypercholesterolemia (FH)

(2/5)

💊 The study tested alirocumab (PRALUENT) at 150 mg every 14 days for 78 weeks + high-intensity statin therapy, and assessed plaque burden by noninvasive coronary CTA imaging in both men and women.

Read 7 tweets

Abdulla A. Damluji, MD, PhD

@DrDamluji

Apr 2

@AnnalsofIM

Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort: @AnnalsofIM

Subclinical disease is common; CTA for prognostication!

Summary 👇👇👇👇

1. This Danish study found that subclinical coronary atherosclerosis may be found in more than half of middle-aged men and one third of middle-aged women without known ischemic heart disease.

2/ The most common type of subclinical disease was nonobstructive and/or nonextensive coronary atherosclerosis.

Read 14 tweets

Abdulla A. Damluji, MD, PhD

@DrDamluji

Mar 31

@CircIntv

Angina After Percutaneous Coronary Intervention: Patient and Procedural Predictors: @CircIntv

1 in 3 patients post FFR guided PCI had symptoms, but delta FFR (pre vs post) may be useful predictor of post PCI angina!

Here is 10 point summary 👇👇👇

1. The TARGET-FFR randomized trial found that one in three patients reported angina 3 months after undergoing percutaneous coronary intervention (PCI), which is a substantial proportion but reported previously in literature.

2. Defining a level of post-PCI angina that might be acceptable to patients or represent a clinically meaningful improvement would be arbitrary metric, as improved but persistent symptoms may be considered a success by some patients yet be completely unacceptable to others.

Read 14 tweets

Abdulla A. Damluji, MD, PhD

@DrDamluji

Mar 30

@JACCJournals

Influence of Culprit Lesion Intervention on Outcomes in Infarct-Related Cardiogenic Shock With Cardiac Arrest: @JACCJournals

Excellent: culprit-only is for AMI-shock and now for AMI-cardiac arrest - @thiele_holger

Here are few highlights, but pls read full study

👇👇

1. In CULPRIT-SHOCK, a cohort with infarct-related cardiogenic shock (CS), more than 54.2% had cardiac arrest (CA) before admission.

That is quite high!

2. Patients with cardiac arrest were younger and had fewer comorbidities, but had a higher rate of impaired end-organ perfusion on admission.

Read 13 tweets

Abdulla A. Damluji, MD, PhD

@DrDamluji

Mar 30

@JAHA_AHA

Prognostic Value of Machine-Learning- Based PRAISE Score for Ischemic and Bleeding Events in Patients With Acute Coronary Syndrome Undergoing PCI: @JAHA_AHA

Editorializing: 3 major applications of AI/ML in medicine: automation, prediction, cognitive reasoning!

Summary 👇👇

1/📊This study investigates PRAISE score for predicting 1-year all-cause mortality, recurrent AMI, and major bleeding events in post-PCI ACS patients treated with DAPT.

Application for #prediction in medicine using 6433 ACS pts

2/🔍Study finds PRAISE score has moderate discrimination for all-cause mortality but poor discrimination for recurrent AMI and major bleeding in an Asian population.

(Chinese cohort)

Read 12 tweets

Share this page!

Abdulla A. Damluji, MD, PhD

People who liked this thread also liked...

Try unrolling a thread yourself!

More from @DrDamluji

Abdulla A. Damluji, MD, PhD

Abdulla A. Damluji, MD, PhD

Abdulla A. Damluji, MD, PhD

Abdulla A. Damluji, MD, PhD

Abdulla A. Damluji, MD, PhD

Abdulla A. Damluji, MD, PhD

Did Thread Reader help you today?

Don't want to be a Premium member but still want to support us?

Send Email!