Believe it or not, the mitochondria in every cell in your body make the MAJORITY of your melatonin. (>95%) in response to infrared light (PMID 36671781, 29164625)
And almost NONE of us are getting enough of it.
We spend >97% of our lives indoors, where there is very little IR light.
If you live 86 years, you will spend 83 of them indoors.
Most of us spend less than 30 minutes per day truly outside. No bueno.
I am not a fan of methylene blue. The data clearly shows that unless you have a block in your electron transport chain, it LOWERS ATP production in your mitochondria.
I think most people are conflating MAO-A inhibition and serotonergic effects with mitochondrial benefit.
Yes, metabolic dysfunction is common but methylene blue is not the way to address this.
The easy root cause solution is to cut out seed oils and processed sugars rather than turning your tongue (and brain) blue.
Sugar is bad for you, but not for the reason you think.
Sugar is NOT bad for you because it raises your blood sugar.
Sugar is bad for you because it causes dysbiosis in your gut => increases endotoxin =>inflammation/metabolic dysfunction.
A thread... 🧵
From the outset, it's important to point out that "naked sugar" (think table sugar= sucrose and high fructose corn syrup) has different effects in the body than sugar consumed as a part of fruits/fruit juice/honey etc.. we'll get to this eventually...
Most believe that "naked sugar" is bad for you because if raises your blood glucose, but there is a dearth of evidence to actually suggest that raising your blood sugar is harmful for humans at all independent of pre-existing diabetes (PMID: 30249012).
Fasting insulin is a SINGLE, CHEAP, EASY BLOOD TEST that could change the health landscape in the United States over night.
If every doctor ordered a fasting insulin ($30) on their patients -and knew how to interpret it**- we would immediately understand how great the burden of metabolic dysfunction in our country is and we could begin targeting it effectively.
The problem here is doctors are NOT taught that:
a) metabolic dysfunction (aka insulin resistance) lies at the root of the MAJORITY of chronic illness in our country...
Increased LP-PLA2 is strongly associated with increased cardiovascular disease (PMIDs: 22499993, 17431184) and cleaves oxidized phospholipids in LDL.
3/8