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Nick Krontiris Profile picture
@nick_krontiris
Apr 14 • 9 tweets • 2 min read Twitter logo Read on Twitter
Here, metabolic syndrome was found associated with elevated long term mortality risk in patients with or without obesity, and obesity was found associated with increased mortality risk even in individuals with metabolically healthy obesity, shedding doubt on the obesity paradox. Image
- The study aimed to evaluate the association between metabolic syndrome and long-term all-cause mortality.
- The LIPIDOGRAM studies were carried out in the primary care in Poland in 2004, 2006 and 2015.
- Metabolic syndrome was diagnosed based on the National Cholesterol Education Program, Adult Treatment Panel III (NCEP/ATP III) and Joint Interim Statement (JIS) criteria.
- Metabolic syndrome was associated with elevated long term mortality risk in both patients with or without obesity.
- Lean patients with metabolic syndrome, despite having more severe metabolic disorders, were less often treated with lipid-lowering drugs.
- Obesity remained associated with increased mortality risk in patients not fulfilling metabolic syndrome criteria...
"...therefore the concept of metabolically healthy obesity should be revised"
Metabolic syndrome is associated with similar long term prognosis in non-obese and obese patients. An analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004-2015 cohort studies

doi.org/10.1093/eurjpc…

#MetabolicSyndrome #Obesity

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More from @nick_krontiris

Nick Krontiris Profile picture
Apr 15
In this one, higher sedentary time was found associated with adverse cardiac structural measures, while higher light physical activity was associated with better cardiac function in adolescents. Image
- This study examined the independent relationships of device-based measured sedentary time and physical activity in relation to cardiac structural and functional geometry among adolescents.
- Higher sedentary time was associated with higher left ventricular mass indexed for height, while higher moderate-to-physical activity was also paradoxically associated with higher left ventricular mass indexed for height.
Read 12 tweets
Nick Krontiris Profile picture
Apr 15
The findings of this study suggest that even short-term inactivity can have a detrimental impact on bone density, even in young and mostly healthy individuals. Image
- The study examined changes in anthropometry, body composition, and physical activity associated with changes in estimated bone mineral density in young men at the beginning and again 18 weeks later at the end of basic military training.
- At the end of basic training, the participants were by average heavier, slightly taller, and had higher fat mass and grip strength.
Read 9 tweets
Nick Krontiris Profile picture
Apr 15
The findings of this one suggest that strength athletes have distinct mitochondrial characteristics with decreased mitochondrial profile size, increased numeric density, increased cristae density and increased surface-to-volume ratio, providing an optimised mitochondrial network. Image
- Substantial mitochondrial structural remodelling appeared to exist in the skeletal muscle of chronically strength-trained athletes (elite power and Olympic weightlifters).
- Despite similar mitochondrial volumetric density, the mitochondria of strength athletes were characterised by smaller size, increased number of mitochondrial profiles, increased cristae density, and increased surface-to-volume ratio.
Read 12 tweets
Nick Krontiris Profile picture
Apr 15
This one not only supports the notion that the physical contact between lipid droplets and mitochondria are a direct pathway for fatty acid delivery to the mitochondrion, it suggests exercise can mediate this contact and that this effect is not affected by metabolic health status Image
- The interconnected nature of the mitochondrial network in the skeletal muscle provides a rapid mechanism for energy production and cellular distribution during exercise.
- The intramuscular mitochondria also form physical membrane-to-membrane contact with triglycerides containing lipid droplets,which isconsidered a direct pathway for fatty acid delivery to the mitochondrion for beta-oxidation.
Read 13 tweets
Nick Krontiris Profile picture
Apr 14
In this one, NAFLD, as assessed by the fatty liver index (FLI), was found associated with the risk of type 2 diabetes in Japanese adults.
* LP (linear predictor) = 0.953*ln[triglycerides (mg/dL)] + 0.139 * BMI (kg/m2) + 0.718*ln[GGT (IU/L)] + 0.053 * waist circumference (cm) - 15.745

* FLI = [e^LP/(1 + e^LP)] * 100
- The FLI was positively associated with the risk of type 2 diabetes.
Read 5 tweets
Nick Krontiris Profile picture
Apr 14
In this one, US adults with higher total carotenoids levels had a lower prevalence of emphysema and chronic bronchitis and lower mortality of respiratory disease.
- This study examined the association of total carotenoids, alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin and lycopene with the prevalence of asthma, emphysema and chronic bronchitis, and mortality of all-cause and respiratory disease.
- Individuals with higher total carotenoids and beta-cryptoxanthin levels had a lower prevalence of emphysema and chronic bronchitis.
Read 5 tweets

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