Nick Krontiris Profile picture
Apr 26 10 tweets 2 min read Twitter logo Read on Twitter
In this one, obesity, but not overweight, was associated with a higher risk of death from middle to older age, irrespective of the adiposity index used, suggesting that obesity should be prevented across the lifespan, including in individuals up to 85 years of age. Image
- Lower risk of mortality in older participants with overweight compared with normal weight when adiposity was assessed by the fat mass index was observed.
- However, the magnitude of this association was small and probably not clinically meaningful.
- A higher risk of mortality was observed in participants with obesity (class I and class II) with similar magnitudes of association whether adiposity was measured by BMI or fat mass index.
- An attenuation of the associations between higher levels of BMI and mortality risk with age was not observed.
- These results contradict previous studies reporting attenuated BMI-mortality associations in older individuals.
- Attenuated associations with higher age in individuals with the highest obesity when adiposity was measured by fat mass index were also not observed.
- However, mortality rates remained higher than in same-aged participants with low-fat mass levels.
- "Our results, therefore, question the idea that moderate levels of fat mass could be protective, which has been based on the hypothesis that higher body fat could provide larger metabolic reserves against frailty and diseases in older populations."
Body composition and mortality from middle to old age: a prospective cohort study from the UK Biobank

doi.org/10.1038/s41366…

#MetabolicSyndrome #Obesity

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Nick Krontiris

Nick Krontiris Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @nick_krontiris

Apr 26
The findings of this one suggest that even though exercise may be beneficial for some aspects of children's cognition (information processing speed), those with higher levels of habitual physical activity may also benefit in other aspects too (executive control efficiency).
- A 15 min bout of physical exercise benefited children's overall information processing speed the most, whereas the efficiency of executive control and other attention networks (alerting and orienting) was unaffected by the duration of the bout.
- However, exercise duration affected the interactive functioning of executive control and orienting networks in more active children, suggesting that the dose–response relation of interest may be moderated by children's habitual physical activity level.
Read 9 tweets
Apr 26
This review tries to address the ideal duration and intensity of physical activity, and the types of exercise for optimizing lifelong cardiovascular health, longevity, and healthspan. Image
Summary:
- Physical fitness is the single best predictor of life expectancy and healthspan. Try to achieve and maintain a high level of physical fitness throughout life.
Read 10 tweets
Apr 25
In this one, a high dose (2.5mg) of phenylcapsaicin was associated with a plausible ergogenic effect on strength performance, muscle damage and peripheral perceived exertion in comparison to a placebo and a lower dose of 0.625mg during resistance training. Image
- The aim of this study was to explore the effects of low dose (0.625 mg) and high dose (2.5mg) of phenylcapsaicin on full squat performance, active muscle and overall body ratings of perceived exertion, muscle damage, protein breakdown, metabolic response, and 24-h recovery.
These assessments were approached under a randomized, triple-blinded, placebo-controlled, crossover design.
Read 9 tweets
Apr 25
This one in hyperinsulinemia- and hyperglycemia- prone mice suggests that both endurance and strength training can be effective ways to mitigate the impacts of hyperglycemia and hyperinsulinemia. Image
- In this study, both short-term endurance and strength training protocols controlled the elevated fasting glucose and insulin, leading to improved whole-body insulin sensitivity and glucose tolerance.
- While endurance exercise appeared to play a vital role in transcriptome and mitochondrial activity, strength exercise mainly affected post-translational mechanisms and protein synthesis.
Read 10 tweets
Apr 25
In this one, females with high levels of physical activity showed a more pronounced flexion-relaxation phenomenon compared to those with moderate and low levels of physical activity, suggesting that high levels of physical activity may lower risk for low back pain. Image
- The flexion relaxation phenomenon is characterized by the reduction of paraspinal muscle activity at maximum trunk flexion.
- This phenomenon is often absent or disrupted in individuals reporting lower back pain.
Read 7 tweets
Apr 25
The findings of this one suggest a possible defect in the transfer of PUFA from peripheral tissues to the liver in NAFLD, with HDL composition being tightly connected to the rewiring of hepatic PUFA composition that occurs in NAFLD. Image
- NAFLD was characterised by a depletion in phospholipids (phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and sphingomyelins) specifically driven by their PUFA fraction.
- NAFLD patients had higher saturated and lower polyunsaturated FFAs.
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(