Simon Ash Profile picture
May 10, 2023 12 tweets 11 min read Read on X
Dr Daniel Katz presents on drug and equipment shortages at @SOAPHQ#SOAPAM2023. He’ll focus on why they occur, how we can prepare and discuss alternatives & substitutions. #OBAnes ImageImage
Why shortages occur (1): Generic drug manufacturing poses strain on supply chains, drugs require precursors (80% manufactured outside US). Supply chain has upstream and downstream components - removing precursors hampers upstream supply chain (before the drug is even… twitter.com/i/web/status/1… ImageImageImageImage
A case study: Fludarabine. Generic 2003: 12 application holders, 6 actively marketing. But who is actually making it? No real time database explaining who is making the product. All May have the precursors stocked. #SOAPAM2023 ImageImageImage
Why shortages occur (2): increased demand, natural disasters, regulations (maximum stores), no minimums, no stockpiles, cannot mandate production, and finally public opinion. #SOAPAM2023 ImageImageImage
Why shortages occur (3): they build on eachother. The case of Akron. Knock on effects tend to multiply. multiple drugs affected by one company. #SOAPAM2023 ImageImageImageImage
What’s different about equipment? Nothing really - a few extra choice points. #SOAPAM2023 Image
What can you do about shortages (1): communication is key, have multidisciplinary approach to planning, conservation when aware of shortage, multilevel advocacy… #SOAPAM2023 ImageImageImageImage
What can you do about shortages (2): substitutions. Be flexible, know what’s available, drugs probably easier than equipment? #SOAPAM2023 ImageImageImageImage
What can you do about shortages (3): drugs continued. Triage/ prioritization required. For antibiotics: know local sensitivity patterns, appropriate dosing of alternatives. #SOAPAM2023 ImageImage
What can you do about shortages (4): use @SOAPHQ #patientsafety resources, ASHP shortages list (ashp.org/drug-shortages…) #SOAPAM2023 ImageImage
Summary from Dr Daniel Katz. #SOAPAM2023 Image
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More from @OBsleepmerchant

May 9
@SQuashie presents an update on anesthesia for operative delivery. Declarations. Methodology and themes. #OAA24ASM #OBAnes

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Gastric USS. Oral rehydration has benefits over NPO wrt vasopressor use. #siptilsend safe, noting some patients have increased gastric volumes irrespective of starvation status. #OAA24ASM #OBAnes
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@SQuashie continues at a rapid pace. To DPE or not to DPE remains a question - 16min vs 19 min, is that 3 min clinically relevant? Esketamine for supplemental analgesia - >95% had psych effects, read @rjharrison79 editorial. #OAA24ASM #OBAnes
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May 9
@Jamesocarroll presents an Update on Labour and Delivery. Disclosures #OAA24ASM #OBAnes

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How the lecture was put together. Screening. Themes. How to interpret the slides. Very Ostheimer-esque @Jamesocarroll #OAA24ASM #OBAnes


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@Jamesocarroll Clinical practice theme: intrathecal catheters & ADP. Intrathecal catheters: No decrease in PDPH, but reduction in EBP. 10mL intrathecal saline decreased PDPH & need for EBP. Of note, the percentage of epidurals requiring multiple attempts. #OAA24ASM #OBAnes

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Read 17 tweets
May 5
8am-ish in Denver and time for a much anticipated session: PDPH beyond the guidelines. Moderated by Dr Lisa Leffert, featuring @Ropivacaine, @euklaas, @sharonOzynger and @WouterSchievink at #SOAPAM2024 #OBAnes

(HT: @Ropivacaine, bless his heart, he knows I hate missing out)

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Hot off the Press? August 2023! @JAMANetworkOpen with quite an illustrious team including @Ropivacaine @robin_russell1 @KalagaraHari @LimGrapes @claralexlobo @noolslucas @NarouzeMD (please tag others if you have their handles?) #SOAPAM2024 #OBAnes

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Introduction, Methods and the 10 questions. #SOAPAM2024 #OBAnes

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Read 11 tweets
Jun 12, 2023
Next up at #CASAM2023 - fittingly keeping the most important academic session to last: #OBAnes
@ValZaph moderating the Maternal Experience and Outcomes: Improving the care we provide. @DrWesleyEdwards

Bookends the 1st #OBAnes session, on intrapartum pain at cesarean section… twitter.com/i/web/status/1… Image
Dr Christina Lamontagne kicks off the session with: Use of Dexmedetomidine in improving maternal experience and outcomes. Nothing to disclose. Then an important disclosure: All indications discussed are OFF LABEL in Canada. Objectives.
#OBAnes #CASAM2023 ImageImageImageImage
Why does Dr Lamontagne use a lot of dexmedetomidine (not only in #OBAnes mind)? Clinical pharmacology of dexmedetomidine (1): highly selective alpha-2 agonist; sedation WITHOUT amnesia at locus coeruleus. #CASAM2023 ImageImageImage
Read 9 tweets
Jun 11, 2023
Dr Ning Nan Wang introduces @harshamd5 to open the chronic pain session: Perioperative use of opioid in the context of Opioid Epidemic. #CASAM2023 ImageImageImage
The opioid crisis isn’t new - China probably remembers the Opium wars that helped establish a British foothold on the continent. Opioids and OUR crisis. Is what we fear the real crisis? Are opioid-related deaths due to surgical prescriptions? No, mostly due to street fentanyl.… twitter.com/i/web/status/1… ImageImageImage
Opioid use around the time of surgery. Understanding nociception vs pain. Does eliminating opioids during surgery make a difference - no definitive conclusions. #CASAM2023 ImageImageImage
Read 11 tweets
Jun 10, 2023
@DrLucieFilteau introduces @CMA_Docs president @AlikaMD for his keynote address at #CASAM2023 Image
@AlikaMD starts with the state of the 🇨🇦 health system, including a little history. #CASAM2023 ImageImage
The 🇨🇦 health system approach to problems, creating new problems as a result with a dangerous lack of interoperability. #CASAM2023 ImageImageImage
Read 12 tweets

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