Thread by @ABaliMD

@djc795 with his top 10 historical #IC trials to know; studies that have had fundamental impact on the field

(Note, this is a summary, but really was a lecture to attend in person. Phenomenal & super fun)

@rwyeh @nadia_sutton @DougDrachmanMD @SrihariNaiduMD
A thread🧵:
(1/6)

1️⃣ ACME & RITA2 - SIHD, randomized PCI v meds -> ⬇️angina (CCS class)

2️⃣ BOAT - directional atherectomy, “bigger is better”. Luminal gain is🤴🏼.

3️⃣ BARI & FREEDOM - angioplasty vs CABG, important interaction of diabetes; LIMA is 🔑

#Fellows2023 @crfheart
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4️⃣ PAMI - PTCA v tPA, significantly ⬇️death/MI, 🚫ICH w/ PTCA

5️⃣ STRESS, Benestent 1&2 - angioplasty vs stenting, showed ⬇️ in binary restenosis and ⬆️ luminal gain w/ stenting. Also, design of monitoring w/ meds v. rpt PTCA on f/u impacts modern trial design

#Fellows2023
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6️⃣ STARS - 💊DAPT v. ASA solo v. Coumadin, 90% ⬇️ in stent thrombosis

7️⃣ DIRECT - perc laser v max dose anti anginals v sham procedure, no difference in QOL. Proved importance of sham control in procedural trial

#Fellows2023 @crfheart
(4/6)

8️⃣ FRISC2, TACTICS - UA/NSTEMI looking at early revasc vs meds, showing benefits in death, MI - benefit confined to biomarker+ groups

9️⃣ SAFER - embolic protection in vein graft PCI, benefit of EPD, ⬇️MACE/death

#Fellows2023 @crfheart
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And lastly:

🔟 WOEST - triple therapy v OAC+clopidogrel, showing marked ⬇️ bleeding in dual therapy group with no difference in f/u ischemia/death/CVA

#Fellows2023

What a lecture! 👏🏽
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Also seeing Dr. Gruentzig’s original poster & a video of Dr. Rentrop’s first percutaneous STEMI angiogram/LVgram

Very inspiring to see how far and quickly this field has come 🙏🏽

@GruentzigSoc @NEJM @ACCinTouch @SCAI @TCTMD
#CardioTwitter #MedEd #ACCFIT