Thread by @KetoCounselor

Research indicates that metabolic pathways play a significant role in regulating the aging process of organisms, suggesting that manipulating metabolism can potentially enhance healthspan and lifespan. (1/15)

So much so, that scientists are currently exploring dietary interventions and compounds that can modulate metabolism as potential anti-aging strategies. (2/15) doi.org/10.1016/j.bj.2…

One particular focus of metabolic interventions aimed at delaying aging is cellular senescence. (3/15)

Cellular senescence refers to a state of stable growth arrest accompanied by various structural and functional changes, including the activation of a pro-inflammatory secretome. (4/15)

What do all these fancy words mean? I will tell you. Because I want you to know all the ways you can feel better (5/15)

That sick cells don't die right. They stay in an in-between zombie state and ooze out a bunch of nonstop pro-inflammatory cytokines that make you sick and age you faster. (6/15)

Do you know what is a great intervention to keep your cells from turning into zombies and oozing inflammation throughout your body? You guessed it—a #ketogenic diet. (7/15)

Studies have shown that beta-hydroxybutyrate (BHB), a ketone body produced during ketosis, may have a positive effect on cellular senescence. (8/15)

BHB can reduce markers of cellular senescence and senescence-associated phenotypes in various cell types. In case you don't believe me, here is an article talking about it doing this with cartilage. (9/15)
sciencedirect.com/science/articl…

Unsatisfied? Need more. Here is one discussing these effects on the cardiovascular system. (10/15) ncbi.nlm.nih.gov/pmc/articles/P…

BHB, one of the ketone bodies you make on a ketogenic diet, has been found to decrease the expression of senescence-associated genes and reduce the secretion of pro-inflammatory factors associated with senescence. (11/15)

Seriously, I am not making this stuff up. It's all right here in the research literature. You just got to look! 🤷 (12/15) doi.org/10.1016/j.smai…

As if all that weren't enough, BHB has been shown to activate specific cellular pathways, such as the AMP-activated protein kinase (AMPK) pathway and the sirtuin 1 (SIRT1) pathway, which are involved in regulating cellular senescence and promoting cellular health. (13/15)

Need a citation to feel confident in your new knowledge? I got you! (14/15) mdpi.com/1752610

Do you want a less bumpy ride on the road to aging, with fewer zombies? Consider a ketogenic diet to upregulate the important pathways in cellular metabolism, energy regulation, and longevity.(15/15) #nozombies #cell #aging