Discover and read the best of Twitter Threads about #aging

Most recents (24)

1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 48 tweets
Excited to share our paper “Somatic genomic changes in single Alzheimer’s disease neurons”, published today in @nature!
nature.com/articles/s4158…
[1/19]
@Nature This was a wonderful collaboration with August Huang @tuihuaorjinhua, mentored by @ChrisAWalsh1 @EAliceLee2 and @_MikeLodato, with contributions from many others across multiple institutions. @BostonChildrens @BrighamWomens @HHMInews @harvardmed @UMassChan @broadinstitute
[2/19]
@Nature @tuihuaorjinhua @ChrisAWalsh1 @EAliceLee2 @_MikeLodato @BostonChildrens @BrighamWomens @HHMINEWS @harvardmed @UMassChan @broadinstitute Somatic mutations in the genome of cells are a major part of how we think about cancer, but recent studies found that somatic mutations also occur in “normal” cells, and build up in neurons and in other cells as we age.
[3/19]
Read 19 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Read 93 tweets
So excited to finally share our paper, now available as a #bioRxiv preprint!

We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..

biorxiv.org/content/10.110…

#newpublication #mitochondria
This project would not have been possible without the fantastic work from many people, so thank you all! @ASW_lab, @Kivela_lab, @WickstromLab, @JMitophile, @AWartiovaara et twitterless al.
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
Recent years have brought several promising approaches to treat different kinds of #mitochondrial dysfunction, and increasing #mtDNA amount has been proposed to be beneficial for certain defects.
Read 11 tweets
I fed a bot 100 of the worst tweets ever (bad takes/cringe) and here's what it came up with. 🧵
people never talk about how post 9/11 glow ups were definitely a thing ✨✨
Ladies, get yourself a bigger man. My husband is 30, 270 pounds and on the cusp of morbidly obese. The hottest blob I've ever known and *knock on wood* if we ever got into a domestic dispute: could not chase me if he tried. ❤️
Read 14 tweets
A landmark identical twin study indicates how a child is raised (e.g. type & amount of food, lack of exercise) influences their rate of aging & how healthy they will be for the rest of their life. How often do we hear, "Oh, they'll grow out of it"? tinyurl.com/4kemv9mb
A child's lifestyle appears to influence a variety of human conditions, such as obesity, type 2 diabetes, cardiovascular diseases, #cancer & #mentalillness
Non-genetic associations with DNA methylation patterns (epigenetic associations) #aging #Health
Read 5 tweets
🎹 I Got Rhythm 🎹

"..aging is associated with the loss of diurnally rhythmic innate immune responses, including MONOCYTE TRAFFICKING FROM BONE MARROW TO BLOOD, response to lipopolysaccharide and phagocytosis.
This decline in homeostatic immune responses was associated with a>
with a STRIKING DISAPPEARANCE OF CIRCADIAN GENE TRANSCRIPTION in aged compared to young tissue macrophages. CHROMATIN ACCESSIBILITY was significantly greater in young macrophages than in aged macrophages; however, this difference did not explain the loss of rhythmic gene>
transcription in aged macrophages. Rather, diurnal expression of Kruppel-like factor 4 (Klf4), a transcription factor (TF) well established in regulating cell differentiation and reprogramming, was selectively diminished in aged macrophages."
Read 7 tweets
🌲 一棵高大的樹抓住風 🌲

A bi0w3ap0n created by a collaboration of elderly scientists and bureaucrats and spread in a country with an ancient history, accelerates aging in a young, modern population.
Read 4 tweets
Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:

-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.
-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.

nature.com/articles/s4358…
Read 4 tweets
Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159… Image
1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature" Image
2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level? Image
Read 13 tweets
🧵To mark the anniversary of the launch of my book "Neglected No More: The Urgent Need To Improve the Lives of Canada's Elders," I'm going to share some reflections on #eldercare #ageism, and lessons of #COVID19. penguinrandomhouse.ca/books/669793/n… @PenguinRandomCA @WCA_LitAgency /1
Elders in long-term care were victims of a "massacre of neglect" during #COVID19. Of the roughly 36,500 #COVID19 deaths in Canada to date, more than 20,000 have been in institutional care. @NoLore has collected the data, no government. docs.google.com/spreadsheets/u… via @NeglectedNo /2
A horror of this magnitude -- 20,000+ elders dead from neglect -- should prompt a dramatic response. But governments have mostly shrugged it off, promising more of the same, not substantive change, and bickering about jurisdiction. theglobeandmail.com/canada/article… via @NeglectedNo /3
Read 22 tweets
(1) A lot of Immunologists are (justifiably) obsessed with T cell exhaustion.

Very few discuss memory inflation 📈 despite its relevance to #vaccines and #aging

#Immunology #TCELL

Diagram and background info mainly from bit.ly/OHara2012
(2) Inflation: induction of memory [CD8+] T cells that increase in frequency over time to >10% of the entire T cell pool in blood and higher abundance in peripheral tissues (e.g. liver and lung)
(3) First reported (to my knowledge) in a mouse model of CMV (MCMV)

Recall (by contrast) how chronic LCMV (clone 13) induces T cell exhaustion
bit.ly/Holtappels2000
bit.ly/Karrer2003
Read 18 tweets
This systematic review and meta-analysis of RCTs comes to the conclusion that ~700 METs-min/week is the minimal dose to elicit clinically important changes in cognition in older adults.
- The estimated minimal exercise dose found that can elicit clinically relevant changes in cognition was 724 METs-min per week, with doses beyond the upper bound of WHO recommended level of physical activity providing less clear benefits.
- 724 METs-min per week is slightly above the lower bound of WHO recommended level of physical activity (i.e. 600 METs-min per week, equivalent to 150 min/week of moderate intensity or 75 min/week of vigorous activity).
Read 12 tweets
In this prospective analysis of the PREDIMED-Plus trial, higher increases of vitamin K dietary intake were associated with a better cognitive function, as assessed by the MMSE test in an adult high cardiovascular risk population followed for 2 years.
- Participants were men aged 55-75 years and women aged 60-75 years, with overweight or obesity, who at baseline met at least three components of the metabolic syndrome.
- This association was not found in the other considered cognitive function tests, with the exception of the semantic verbal fluency test.
Read 4 tweets
This one found an inverse dose–response relationship between diet quality and prevalence of both physical and comprehensive frailty in adults aged ≥ 65 years living in Kameoka City, Japan.
- Higher adherence scores signified a higher intake of vitamin C, vegetables, dairy products, and fruits.
- Higher scores of adherence to vegetable dishes and milk intake were inversely associated with both physical and comprehensive frailty.
Read 4 tweets
The objectives of this study were to examine whether weight loss, weight status, based on BMI categories, and abdominal obesity, as assessed by waist circumference, are associated with mortality risk in community-dwelling older adults during a 17-year follow-up.
- Self-reported weight loss was not associated with all-cause mortality after adjusting for health and lifestyle factors.
- However, men who self-reported weight loss of more than 3 kg had a 52% increased mortality risk compared to those who reported no weight loss.
Read 6 tweets
⏱️ The Sounds of Senescence ⏱️
"We have recently shown that SC2 SPIKE PROTEIN promotes an inflammatory cytokine interleukin 6 (IL-6)/IL-6R-induced trans signaling response and alarmin secretion. Virus-infected OR SPIKE TRANSFECTED HUMAN EPITHELIAL CELLS EXHIBITED AN INCREASE IN SENESCENCE.>
Read 12 tweets
Daily Bookmarks to GAVNet 02/19/2022 greeneracresvaluenetwork.wordpress.com/2022/02/19/dai…
How is the “Purcell principle” threatening voting rights in America? | The Economist
economist.com/the-economist-…
#PurcellPrinciple, #VotingRights, #USA
Read 13 tweets
🧵12 scientific Twitter accounts you should go follow for the latest updates on #GutMicrobiome-host interaction research: 🦠👩‍🔬🧪⬇️

#aging #immune #nutrition #probiotics #brain #SciComm
1/12. @bykriscampbell - Kristina Campbell, MSc, is a #SciComm extraordinaire. Her tweets give excellent summaries of cutting edge #GutMicrobiome-host publications primarily #FMT #probiotics and #Disease
2/12. @john_damianosMD - Dr. John Damianos tweets about all things #Microbes and #Medicine. We're talking #Probiotics, #IBD, and more, from the prospective of a clinician.
Read 18 tweets
Our latest work is now online @eLife! Studying gene exp. across #mice #lifespan, we show that tissues diverge from each other during #development but tend to converge back during #ageing - potentially losing tissue identity 🧵(1/n)
#aging #bioinformatics
elifesciences.org/articles/68048
(2/n) Studying gene expression trajectories, we found that developmental trajectories don't necessarily continue into ageing (gene expression trajectories show reversal). but, reversals were not shared across tissues 🤨
(3/n) We, then, hypothesised that reversals may contribute to tissue divergence during development while they are gaining a "tissue identity" but convergence during ageing as they lose their tissue-specific expression signatures 🤔
Read 7 tweets
Something is changing about how scientific research is funded.

@Jasonmmast @endpts covers a growing set of science funding experiments: endpts.com/inside-the-mul…
These include high-throughput grants (e.g. #Fast, #Impetus), new institutes (@ArcadiaScience, @AltosLabs, @arcinstitute... I guess A is for new beginnings?), and new structures like 'nonprofit startups' (@Convergent_FROs) & @newscienceorg.
As with all experiments, I expect that some of these will disappear and that others will be a central part of science in ten years.
But them happening at all is enough to renew a conversation about how science is funded and conducted.
Read 9 tweets
💸 98 Longevity Impetus Grants were awarded in 2021, thanks to generous donations from @juanbenet @jamesfickel @VitalikButerin @JedMcCaleb @KarlPfleger @FEhrsam and 1 anonymous donor.
I'll summarize outcomes in this thread, awardees listed in prior one:
🦸🏽 While I've been doing most of the tweeting, the Longevity Apprentices @LNuzhna @kush__sharma @edmarferreira & Tara Mei are the real heroes for running the operations.
This has been a great Apprenticeship project, merging action and exposure to research
martinborchjensen.com/apprenticeship
🚅 The review + awards process was fairly smooth, thanks in part to @kush__sharma's custom reviewer UI. Several reviewers told us unprompted that it was their best review experience ever; the UI took 2 wks to make, so there's low hanging fruit for other agencies in that area.
Read 13 tweets
#Read this new #Report while there’s still time to act!

bakerinstitute.org/research/us-ch…

“US-#China Competition Enters the Decade of Max Danger: #Policy Ideas to Avoid Losing the 2020s”

My latest with Gabe Collins @BakerInstitute!

@RiceUniversity
@RiceUNews
@CES_Baker_Inst
#Xi
#Taiwan
As #PRC/#CCP power peaks over this decade, #Xi may seek #Taiwan as historic prize.

To protect their security & rules-based order, US/Allies must mobilize immediately to deter aggression.

The mission is vital, the stakes are high, & the clock is ticking.

bit.ly/PLA2027 Image
US/Allies/#Taiwan now face “#DecadeOfDanger” w/ peaking #Xi/#CCP/#PRC as #China has extreme version of “S-Curved #slowdown.”

Xi’s risk acceptance will likely be amplified by his track record of largely-uncountered revisionist actions vs. neighbors & RBO.

bakerinstitute.org/research/us-ch…
Read 42 tweets

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