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🇺🇸🤝🇺🇦eastvillagetwt Profile picture
@eastvillagetwt
May 21 • 8 tweets • 6 min read Twitter logo Read on Twitter
A lot of people are starting to notice IMHO. $NWBO #DCVaxL
Phase 3 results: $NWBO #DCvaxL

Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination w/Extension of Survival Among Patients w/[BOTH] #NewlyDiagnosed & #Recurrent #Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial #CancerVaccine

jamanetwork.com/journals/jamao…
Mind blowing interim, unpublished data #DCVaxL data from UCLA #DrLindaLiau presentation for use with adjuvant #PolyICLC #TLR3Agonist #Hiltonol #glioblastoma #cancervaccine
Shorts can claim insane notions, but this is extremely credible data. Results with confirmations from doctors at major institutions who were involved & patients and side arm trial data. It’s a rare disease, orphan designation. Same disease that killed numerous luminaries.
Patient quality of life #QOL immensely improved w/very few to virtually no side effects. Easy treatment, injections at the doctor’s office, with less frequency over time. Not all doctors or oncology industry will love that part. Expected it can be used for other tumors. #DCVaxL
Thread with Patient stories, testimonials, tweets and more information including a spectrum tv feature of #DrLindaLiau #DCVaxL $NWBO.

As far as I know, these patients are still alive.
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More from @eastvillagetwt

🇺🇸🤝🇺🇦eastvillagetwt Profile picture
May 22
$NWBO #DCVaxL
The #PolyICLC adjuvant has already been approved for adjuvant use in other cancers. Under new FDA rules, real world data and validation of the results already seen may make it very easy not only to expand the label and access to #Hiltonol, but also ease insurance / Medicare if
If #DCVaxL is approved. It should be straightforward to add #PolyICLC $NWBO.

See, “Poly ICLC (Hiltonol®): an immune adjuvant targeting the Toll-like receptor 3 (TLR3) pathway; approved for subsets of patients with squamous cell carcinoma”

cancerresearch.org/treatment-type…
Read 8 tweets
🇺🇸🤝🇺🇦eastvillagetwt Profile picture
Mar 20
Granted: Commercial manufacturing license (MIA) at Sawston, for CDMO Advent at the $NWBO owned factory for manufacturing #DCVaxL, it’s successful #cancervaccine for #GBM & any solid tumor ultimately.

Next step, Marketing Approval, BLA.

cms.mhra.gov.uk/mhra/mia/uk-mi…
Background:

Northwest Biotherapeutics Announces Filing of Application for License for Commercial Manufacturing at Sawston, UK Facility

From July 6, 2022

nwbio.com/northwest-biot…
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients w/Newly Diagnosed & Recurrent Glioblastoma: Phase 3 Prospective Externally Controlled Cohort Trial | JAMA Oncology $NWBO #DCVaxL #Phase3

jamanetwork.com/journals/jamao…
Read 7 tweets
🇺🇸🤝🇺🇦eastvillagetwt Profile picture
Mar 20
Commercial manufacturing license for designated contract manufacturing manager for Sawston, the $NWBO factory for manufacturing #DCVaxL, it’s successful #cancervaccine for solid tumors, first for #GBM

Next step, commercial marketing approval, BLA, etc.

cms.mhra.gov.uk/mhra/mia/uk-mi
Background:

Northwest Biotherapeutics Announces Filing of Application for License for Commercial Manufacturing at Sawston, UK Facility

From July 6, 2022

nwbio.com/northwest-biot…
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients w/Newly Diagnosed & Recurrent Glioblastoma: Phase 3 Prospective Externally Controlled Cohort Trial | JAMA Oncology $NWBO #DCVaxL #Phase3

jamanetwork.com/journals/jamao…
Read 6 tweets
🇺🇸🤝🇺🇦eastvillagetwt Profile picture
Mar 19
Not just the Saudi deal, see this short thread for more and worse deals, involving what looks like blackmail, IMHO, with Qatar.
DEMOCRATS WANT ANSWERS ABOUT JARED KUSHNER’S VERY SHADY MIDDLE EAST DEAL (NO, NOT THE SAUDI ONE!)

This is the one involving a miraculous financial bailout for his family, Qatar, and his White House work in the Middle East.

vanityfair.com/news/2022/12/j…
Top senator seeks answers over Qatar link to $1.2bn Kushner property rescue

This article is more than 5 months old
Senate finance panel chair sends detailed questions to financial firm on deal for property owned by then White House aide’s family

theguardian.com/us-news/2022/o…
Read 5 tweets
🇺🇸🤝🇺🇦eastvillagetwt Profile picture
Mar 19
Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy from 2011, #DCVaxL with #PolyICLC #Glioblastoma #GBM

aacrjournals.org/clincancerres/…
#DCVaxL & #PolyICLC #TLR3Inhibitor as adjuvant, have been an impressive combination since 2011:

Results: DC vaccinations are safe and not associated with any dose-limiting toxicity.
The median overall survival from the time of initial surgical diagnosis of glioblastoma was 31.4 months, with a 1-, 2-, and 3-year survival rate of 91%, 55%, and 47%, respectively.
Read 7 tweets
🇺🇸🤝🇺🇦eastvillagetwt Profile picture
Mar 18
Now Tim Scott wants to embrace the likely false notion that COVID was manufactured and released intentionally. That leads to war with China. That is irresponsible absent evidence in reality. It's destructive, not constructive and embraces reactionary emotion, not rationality.
Whatever the case, all of us are against fentanyl being illegally smuggled and distributed and in fact Biden has been very effective at interdicting it at the border. Republicans use the seizures as if they are evidence of lack of enforcement, which is an absurdity.
We want all of our brothers and sisters in all states, but ESPECIALLY the red states, to stay off fentanyl and all addictive and destructive drugs and hopefully they can start then to see how insane GOP politics have become. They say one thing but mean the other thing.
Read 4 tweets

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