ATS Crit Care Profile picture
May 22, 2023 6 tweets 5 min read Read on X
Here we go #ATS2023

Let’s talk about next generation trials.

First up is Mattew Semler discussing the ABCs of future trials.

@atscommunity Image
The equilibrium is being disrupted and new evolving trial designs are emerging

#ATS2023 @atscommunity Image
@MichelleNgGong discussing advantages of platform trials compared to traditional trials which be costly and ineffective

Frequent analyses, multiple interventions can be studied and ability to add additional arms are advantages of platform trials

#ATS2023 @atscommunity ImageImage
🗑️vs⛱️are types of platform trials

✅ not all disease can be assessed with platform trials
✅ harder to secure funding

@MichelleNgGong @atscommunity #ATS2023 Image
@ecgoligher discussing adaptive and bayesian trial designs

Adaptive=modifiable features of the trial

✅ Can address the uncertainties of traditional trials
✅ Data will need to be analyzed during the trial

Bayesian=strength of evidence/learn as you go
@JonathanCaseyMD making the case for pragmatic trials to address challenges in critical care trials

✅ interventions are embedded in routine care
✅ results generalizable
✅ can be completed faster Image

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More from @ATSCritCare

May 23, 2023
C4: Making it Personal: Individualizing Resuscitation Targets - Pavan Bhatraju #ATS2023
Image
Can molecular phenotypes guide resuscitation? Image
Read 4 tweets
May 23, 2023
Next up: Dr Elizabeth Munroe, when do we add vasopressors in #sepsis ?

#ATS2023 @atscommunity

Early vasopressors will:
- control shock faster
- allow leas fluids

Look up the #CENSER and #CLOVERS trials
In #CLOVERS restrictive fluid groups show no difference in major outcomes compared to liberal group
How do we administer vasopressors?

Do we always need a CVC?

Check out the reviews 👇🏻 Image
Read 5 tweets
May 23, 2023
Dr Ivor Douglas discussing pathophysiology of IV fluids and vasopressors in #sepsis

#ATS2023

Follow below for highlights!

@atscommunity Image
Too much or too little fluids can have consequences.

What is the optimal range for fluids? Image
Excess fluid balance (> 5L in 1st day) is associated with increased mortality Image
Read 6 tweets
May 21, 2023
Next: This is your brain on (ICU) Drugs - Image
First up - Tackling delirium - an educational tool to improve nursing-level identification with Dr. Balaban
Nursing level education improvement with educational modules may improve detection of delirium in ICU ImageImage
Next up - Dr. Anderson presents standardized metrics for sedation and delirium assessment -
🗣️ Educational, time interval assessment and performance feedback resulted in greater fidelity to guideline recommendations. ImageImage
Read 8 tweets
May 21, 2023
Next: ⁦@MichelleNgGong⁩ and Ivor Douglas ⁦@com543⁩ presenting the CLOVERS trial - early or liberal fluid management for sepsis induced hypotension nejm.org/doi/full/10.10…
CLOVERS visual abstract Image
Complex protocols for both Fluid Liberal and Fluid Conservative arms.

Options in each arm to allow for "Rescue" for fluids or vasopressors based on pre-specified criteria
Read 12 tweets
May 21, 2023
Up next: @erinkkross presenting on investigation of methods to improve goals of card (GOC) communication for critically ill patients
jamanetwork.com/journals/jama/…
Study first author is the late and very missed @JRandallCurtis1.

mednews.uw.edu/news/curtis/in…
Rationale: clinicians don't discuss GOC communications, but pragmatic *and* efficient strategies to increase and improve these critical interactions are lacking

jamanetwork.com/journals/jamai…
Read 19 tweets

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