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May 27, 2023 8 tweets 3 min read Read on X
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease

@ScienceAdvances #Meded #MedTwitter #Alzheimers

science.org/doi/10.1126/sc…
Characterization of small EVs and macrosomes, and their influence on Aβ40 fibrillation. Image
Effect of small EVs or macrosomes on Aβ40-mediated cytotoxicity. Image
Impact of macosomes on Aβ40 aggregation–related cellular signaling pathway. Image
Assessment of cognitive decline in APP/PS1 Tg mice through Morris water maze and nesting building tests. Image
Macrosomes reduce Aβ accumulation and inflammatory responses in the brain of AD mice. Image
Binding affinity and sites of Aβ40 with macrosomes. Image
Proteomics of macrosomes and small EVs. Image

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