Thread by @isciverse

Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease

@ScienceAdvances #Meded #MedTwitter #Alzheimers

science.org/doi/10.1126/sc…

Characterization of small EVs and macrosomes, and their influence on Aβ40 fibrillation.

Effect of small EVs or macrosomes on Aβ40-mediated cytotoxicity.

Impact of macosomes on Aβ40 aggregation–related cellular signaling pathway.

Assessment of cognitive decline in APP/PS1 Tg mice through Morris water maze and nesting building tests.

Macrosomes reduce Aβ accumulation and inflammatory responses in the brain of AD mice.

Binding affinity and sites of Aβ40 with macrosomes.

Proteomics of macrosomes and small EVs.