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In this one in patients with acute coronary syndrome, reductions in LDL particle electronegativity were linked to alterations of the LDL lipidome, and were associated with all-cause and cardiovascular mortality beyond some established risk factors during a 1-year follow-up. 
"In a prospective cohort of contemporary patients with ACS, we demonstrate for the first time that attenuated LDL electronegativity, as assessed by the L1-L5 ratio...
"...unfavorably associates with all-cause and cardiovascular mortality after the index ACS, over and above the updated GRACE risk score...
"...Moreover, our data suggest that the lipidome of LDL particles markedly differs depending on their charge, with the majority of highest-ranked lipid species independently associating with adverse events...
"...Importantly, LDL electronegativity represented the second highest-ranked predictor of all-cause death, and superseded several clinical risk factors for the prediction of cardiovascular death at 1 year...
"...While the exact mechanism underpinning this phenomenon warrants further study...
"...it is interesting to note that electronegative properties of LDL particles determine their LDL-receptor (LDLR) affinity, with changes in LDL charge impinging on their pro-thrombotic and pro-atherogenic effects."
Low-density lipoprotein electronegativity and risk of death after acute coronary syndromes: A case-cohort analysis (open access)
doi.org/10.1016/j.athe…
#MetabolicSyndrome #Cholesterol #Triglycerides
doi.org/10.1016/j.athe…
#MetabolicSyndrome #Cholesterol #Triglycerides
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