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Daniel Grimaldes MD🇧🇴 Profile picture
@DrGrimaldesJ
Jun 8 • 4 tweets • 2 min read Twitter logo Read on Twitter
The #HEPATOCINS🧬 induced by #EXERCISE🏃‍♂️

✔️Improves insulin sensitivity, inflammation and mitochondrial function
✔️IMPROVING AND PREVENTING: METABOLIC SYNDROME, HYPERTENSION, TYPE 2 DIABETES AND NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)🔥
Exercise not only induces secretion of myokines (skeletal muscle) but also Hepatokins 👉 proteins secreted by the liver

✅Type of exercise Frequency 👉Hepatocin👉Effect

🏃‍♂️Aerobic, 90 min/day, 3-5 days/week👉Adropin🧬👉reduces arterial stiffness and improves endothelial function
🏃‍♂️Aerobic, 120 min/week👉 ANGPTL4🧬👉 absorption of fatty acids and use as energy fuel

🏃‍♂️Aerobic 30-45 min/day, 3 days/week or 🏋️‍♀️Resistance, 3 days/week👉Fetuin A, Fetuin B, FGF21🧬👉 Type 2 Diabetes Prevention
🏃‍♂️Aerobic 12 mts/min up to 30 min, reach 60 min or Resistance 3 series of 5 repetitions, 3 sessions/week🏋️‍♀️👉FST🧬👉improve muscle disorders mdpi.com/2077-0383/10/3… Image

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More from @DrGrimaldesJ

Daniel Grimaldes MD🇧🇴 Profile picture
Jun 9
Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

1️⃣Mg2+ Deficiency

Causes: los dietary Mg ínstame, impared gastrointestinal absorption, drugs, ethanol abuse, genetic factors, impaired renal function Image
Moderate/subclinical deficiency of Mg 2+ induces low-grade chronic inflammation < inflammatory cytokines and production of free radicals < hypertension, cardiovascular disorders, metabolic syndrome and diabetes
tandfonline.com/doi/full/10.21…
openheart.bmj.com/content/5/1/e0…
2️⃣ Mg 2+ and Obesity

Obese subjects > their energy comes from the diet rich in refined cereals and simple sugars > they have liver catabolism of very active glucose.

✔️Several enzymes of glucose oxidation pathways are dependent on Mg 2+
Read 18 tweets
Daniel Grimaldes MD🇧🇴 Profile picture
Jun 9
#WALKING🚶‍♂️ CAN HALF THE INFLUENCE OF GENES ON #OBESITY

❎ Watching too much television📺 can worsen your genetic tendency towards obesity,
✅ But you can cut the effect in half if you walk briskly for an hour a day🚶‍♂️⌚, report researchers at the sciencedaily.com/releases/2012/…
American Heart Association's 2012 Scientific Sessions on Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism

❌A sedentary lifestyle🛌 marked by watching TV 4 hours a day increased genetic influence by 50 percent👀
🤓 Each gene that increases BMI 👉 was associated with 0.13 kilograms/square meter (kg/m 2 ) in BMI.
🚴‍♂️ The highest level of physical activity significantly reduced Obese genes 👉 reducing BMI 👉 comparing 0.08 vs. 0.15 kg/m 2
Read 5 tweets
Daniel Grimaldes MD🇧🇴 Profile picture
Jun 8
Food😋 sources of neurotransmitters🧠
mdpi.com/2072-6643/10/5…
Sources of #Acetylcholine (ACh):
Eggplant, bitter orange, common bean, foxglove, mistletoe, mung bean, nettle, pea, radish, spinach, pumpkin, wild strawberry. Image
Sources of #Glutamate:
Caviar, cheese, crackling, chips, dried cod, fish sauces, gravies, instant coffee powder, meats, miso, mushrooms, noodle dishes, oyster sauce, Parmesan cheese, ready-to-eat meals, salami, savory snacks, seafood, seaweeds, soups, spinach, stews, tomato Image
Read 13 tweets
Daniel Grimaldes MD🇧🇴 Profile picture
Jun 8
WHAT TIME DEADLINE IS IDEAL FOR DINNER WITHOUT AFFECTING OUR HEALTH? frontiersin.org/articles/10.33…

>Nonagenarians and Centenarians were studied in a city in Italy. Image
➡️It was shown that his longevity was based on:
✔️Eat vegetables🥬, fruits🍎 and animal protein (meat)🥩
✔️Moderate physical activity continues🏃‍♂️🚶‍♂️
✔️Low carbohydrate diet
🎯The most striking thing is that they HAD DINNER at 7:30 PM🕰️ and DID NOT EAT FOR 17.5 hours every day after dinner.

They made a comparison with people with metabolic diseases (diabetes, hypertension, etc) that just eating dinner at 9 pm changed their health.👈
Read 4 tweets
Daniel Grimaldes MD🇧🇴 Profile picture
Jun 8
😋Consumption of #KIWI 🥝 improves #DREAM 😴

✔️ Kiwis have been shown to contain melatonin (24 µg/g) 👉 regulates circadian rhythm 👉 reconciles and maintains sleep.
✔️ Kiwis contain serotonin (5.8 µg / g) 👉 improves sleep and mood. Image
✔️Kiwis contain folate 👉 improve folate status 👉 improve sleep
Since Folate (Vit. B9) deficiency has been linked to insomnia and restless leg syndrome.
Consuming 2 kiwis🥝🥝 1h before going to bed for 4 weeks significantly improved total sleep time😴 as measured by actigraphy (16.9%) and sleep efficiency (2.4%) mdpi.com/2072-6643/15/1…
pubmed.ncbi.nlm.nih.gov/21669584/
pubmed.ncbi.nlm.nih.gov/36998905/
Read 4 tweets
Daniel Grimaldes MD🇧🇴 Profile picture
May 1
Synergistic Action of Membrane-Bound and Water-Soluble Antioxidants in Neuroprotection:
ZEAXANTHIN, LUTEIN, VITAMIN E, VITAMIN C AND OMEGA-3
mdpi.com/1420-3049/26/1…
The potential of dietary micronutrients to maintain membrane fluidity and prevent chronic inflammation focuses on membrane-soluble components that act synergistically (zeaxanthin, lutein, vitamin E and AGPI omega-3) and water-soluble components (vitamin C and various phenols).
The prevention of neurodegeneration during aging and the support of optimal brain function throughout life require the protection of the structure and function of the membrane
Read 18 tweets

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