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Nick Krontiris Profile picture
@nick_krontiris
Jun 13 • 7 tweets • 2 min read Twitter logo Read on Twitter
The findings of this one suggest that carotid artery intima‐media thickness is associated with the long‐term risk of developing first‐ever carotid plaque, independent of several traditional cardiovascular risk factors. Image
- This study undertook an individual participant data meta‐analysis of 20 prospective studies from the Proof‐ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline carotid artery intima‐media thickness (CCA‐IMT)...
...and incident carotid plaque involving 21,494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline.
- Mean baseline age was 56  years, 55% were women, the median follow‐up was 5.9 years, with 8,278 individuals developing first‐ever carotid plaque.
- Carotid intima‐media thickness measured at the common carotid artery at baseline was positively and approximately log‐linearly associated with the long‐term risk of developing carotid plaque.
- This association was independent of several traditional cardiovascular risk factors and was robust across several subgroup and sensitivity analyses.
Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies (open access)

doi.org/10.1161/JAHA.1…

#Atherosclerosis #MetabolicSyndrome

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More from @nick_krontiris

Nick Krontiris Profile picture
Jun 16
This systematic review finds that overall the literature suggests that daily low-carbohydrate intake is not likely to negatively affect psychological well-being, or that this type of diet is worse than any other in this respect. Image
- This systematic review evaluated the impact of a carbohydrate-restricted or ketogenic diet on psychological outcomes.
- The potential synergistic effect of carbohydrate restricted diets/ketogenic diets and physical activity or social factors on psychological outcomes was also considered.
Read 14 tweets
Nick Krontiris Profile picture
Jun 15
The findings of this one in mice suggest that dietary nitrate is capable of preserving mitochondrial bioenergetics during skeletal muscle disuse, and maintain mitochondrial-specific function during short-term (but not long-term) limb immobilization. Image
- Skeletal muscle disuse reduces muscle protein synthesis rates and induces atrophy, events associated with decreased mitochondrial respiration and increased reactive oxygen species (ROS).
- Since dietary nitrate can improve mitochondrial bioenergetics, this study examined whether nitrate supplementation attenuates disuse-induced impairments in mitochondrial function and muscle protein synthesis rates.
Read 9 tweets
Nick Krontiris Profile picture
Jun 15
Here, compared with men at the lowest end of the normal BMI spectrum, increased risk for an early acute coronary event was detectable already within the normal range of BMI at the age of 18 years, increasing to >5‐fold in the highest weight category at the age of 40 years. Image
- Coronary heart disease remains the dominant cause of death worldwide.
- This study aimed to determine whether body mass index at conscription predicts early acute coronary events among men in Sweden.
Read 7 tweets
Nick Krontiris Profile picture
Jun 15
This one found that among patients with newly diagnosed diabetes, a reduction in exercise frequency was related to increases in the risk of pneumonia and upper respiratory tract infection in Korean adults. Image
- The risks of both pneumonia and upper respiratory tract infection increased when moderate-to-vigorous physical activity frequency was reduced from ≥ 5 times of moderate-to-vigorous physical activity/week to a state of physical inactivity.
- However, a reduction in moderate-to-vigorous physical activity frequency from ≥ 5 to < 5 times/week only increased the risk of pneumonia.
Read 5 tweets
Nick Krontiris Profile picture
Jun 15
Here, a triple agonist that interacts with GLP-1, neuropeptide Y1&Y2 receptors, regulated insulin secretion in rat and human pancreatic islets, promoted insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo and reduced food intake and body weight in rats. Image
- Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY).
- PYY1–36 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system nuclei that control appetite regulation in the brain including the brainstem area postrema and nucleus tractus solitarius, where it has an orexigenic effect.
Read 9 tweets
Nick Krontiris Profile picture
Jun 15
This one in mice suggests that chronic inflammation, and specifically IL-6 levels, may lead to increases in frailty and physical decline due to skeletal muscle changes that are mediated by changes in mitochondrial regulation and autophagy. Image
- This study focuses on a humanized inducible IL-6 model "due to the significant homology between mouse and human IL-6 at the amino acid level".
- The goal of this study was to better understand the role of IL-6 in frailty.
Read 8 tweets

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