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Nick Krontiris Profile picture
@nick_krontiris
Jun 15 • 7 tweets • 2 min read Twitter logo Read on Twitter
Here, compared with men at the lowest end of the normal BMI spectrum, increased risk for an early acute coronary event was detectable already within the normal range of BMI at the age of 18 years, increasing to >5‐fold in the highest weight category at the age of 40 years. Image
- Coronary heart disease remains the dominant cause of death worldwide.
- This study aimed to determine whether body mass index at conscription predicts early acute coronary events among men in Sweden.
- This was a population‐based Swedish cohort study of conscripts (n=1 668 921; mean age, 18.3 years; 1968–2005), with follow‐up through linkage to the nationwide Swedish patient and death registries.
The follow‐up period started at the date of conscription (baseline) and ended on December 31, 2017.
- This study identified elevated BMI in adolescence to be associated with a high relative risk of early acute coronary events detectable already within the normal weight range at the age of 18 years, increasing to >5‐fold in the highest weight category at the age of 40 years.
Body Weight in Adolescent Men in Sweden and Risk of an Early Acute Coronary Event: A Prospective Population‐Based Study (open access)

doi.org/10.1161/JAHA.1…

#Obesity #MetabolicSyndrome

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More from @nick_krontiris

Nick Krontiris Profile picture
Jun 16
This systematic review finds that overall the literature suggests that daily low-carbohydrate intake is not likely to negatively affect psychological well-being, or that this type of diet is worse than any other in this respect. Image
- This systematic review evaluated the impact of a carbohydrate-restricted or ketogenic diet on psychological outcomes.
- The potential synergistic effect of carbohydrate restricted diets/ketogenic diets and physical activity or social factors on psychological outcomes was also considered.
Read 14 tweets
Nick Krontiris Profile picture
Jun 15
The findings of this one in mice suggest that dietary nitrate is capable of preserving mitochondrial bioenergetics during skeletal muscle disuse, and maintain mitochondrial-specific function during short-term (but not long-term) limb immobilization. Image
- Skeletal muscle disuse reduces muscle protein synthesis rates and induces atrophy, events associated with decreased mitochondrial respiration and increased reactive oxygen species (ROS).
- Since dietary nitrate can improve mitochondrial bioenergetics, this study examined whether nitrate supplementation attenuates disuse-induced impairments in mitochondrial function and muscle protein synthesis rates.
Read 9 tweets
Nick Krontiris Profile picture
Jun 15
This one found that among patients with newly diagnosed diabetes, a reduction in exercise frequency was related to increases in the risk of pneumonia and upper respiratory tract infection in Korean adults. Image
- The risks of both pneumonia and upper respiratory tract infection increased when moderate-to-vigorous physical activity frequency was reduced from ≥ 5 times of moderate-to-vigorous physical activity/week to a state of physical inactivity.
- However, a reduction in moderate-to-vigorous physical activity frequency from ≥ 5 to < 5 times/week only increased the risk of pneumonia.
Read 5 tweets
Nick Krontiris Profile picture
Jun 15
Here, a triple agonist that interacts with GLP-1, neuropeptide Y1&Y2 receptors, regulated insulin secretion in rat and human pancreatic islets, promoted insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo and reduced food intake and body weight in rats. Image
- Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY).
- PYY1–36 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system nuclei that control appetite regulation in the brain including the brainstem area postrema and nucleus tractus solitarius, where it has an orexigenic effect.
Read 9 tweets
Nick Krontiris Profile picture
Jun 15
This one in mice suggests that chronic inflammation, and specifically IL-6 levels, may lead to increases in frailty and physical decline due to skeletal muscle changes that are mediated by changes in mitochondrial regulation and autophagy. Image
- This study focuses on a humanized inducible IL-6 model "due to the significant homology between mouse and human IL-6 at the amino acid level".
- The goal of this study was to better understand the role of IL-6 in frailty.
Read 8 tweets
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Jun 14
Here, despite younger age at diagnosis, lower prevalence of obesity and diabetes family history, individuals with recently diagnosed type 2 diabetes who had a low birthweight were more likely to have greater use of glucose-lowering medications and a larger burden of comorbidity. Image
- Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset.
- This study examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset.
Read 10 tweets

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