Teddy Hla Profile picture
Jun 19 10 tweets 6 min read Twitter logo Read on Twitter
Next up Dr Stuart Gilon
discussing with detailed evidence. #UKECPR23 @tamishtah @iceman_ex @MLSCourse
@tscquizzato great work
onlinelibrary.wiley.com/doi/full/10.11…
Initial #shockable rhythm is better. ARREST trial remains key. Gotta talk about this when chatting the #ECPR thelancet.com/article/S0140-…
Bear in mind - ARREST trial selects shockable rhythm patient. But BLS is key. Looking at old study in Amsterdam pubmed.ncbi.nlm.nih.gov/12104106/
Difference in PE patients however. This is from Prague OOHCA post hoc analysis #UKECPR23 pubmed.ncbi.nlm.nih.gov/37172033/
jamanetwork.com/journals/jama/… Prague OOHCA study. Pre-hospital ROSC is highly beneficial.
Final study: Dutch Multicentre study - median time to ECPR is however longer. and variable institutional experience. e.g., < 10 cases in 1 year. pubmed.ncbi.nlm.nih.gov/36720132/
High volume centres defined as >12 cases / year has significantly significant better outcomes journals.lww.com/ccejournal/Ful… @iceman
@MLSCourse
In summary - ECPR evidence from trial suggest evidence is greatest when truly refractory, initial rhythm is shockable and rapid initiation of ECPR @MLSCourse @tamishtah @iceman_ex #UKECPR23

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More from @teddyhla

Jun 19
Dr Nicholas Barrett, president of @EuroELSO discussing Research in this area, especially clinical data registries @iceman_ex @MLSCourse @tamishtah #UKECPR23
Image
But what #kind of #registries ? - Patient, Specialty, Device ? e.g., Abiomed Imeplla registry data. Regulatory process is different - FDA normally requires RCT. Abiomed registry data was compelling , resulting in +++ impella uptake in USA. #UKECPR23
Read 16 tweets
Jun 19
Session 1 : Starting with recapping #latest evidence in #ECPR with Drs James Raitt, Stuart Gilon, and Dr Nick Barrett with @doctorbrijpatel #UKECPR23 @Novicelearner9 @djlowcock @tamish @DineshCallum @MLSCourse
Dr James Raitt - Cons in EM and PHEM at Thames Valley Air Ambulance - cardiac arrest ; where are we now? #UKECPR23
Read 15 tweets
Oct 25, 2022
Carolyn Calfee Clinical and Biological phenotypes of ARDS
- what do they have in common?

ARDS : subgrouping since the begining
- sepsis vs. non sepsis
- hyper vs. hypoinflamm
- reactive vs uninflamed
#ventilation #ards #phenotypes #LIVES2022
Are clinical phenotypes biologically distinct?
looking at Trauma vs. Non trauma

ICAM-1 , SP-D, vWF, sTNFr-1 are different.
What about in "Direct" vs. "indirect"
or "Diffuse" vs "focal" -- sRAGE comes up again.

pubmed.ncbi.nlm.nih.gov/17944012/
#ventilation #ARDS #LIVES2022
Image
Read 13 tweets
Oct 25, 2022
Mariangela PELLEGRINI
Uppsala- Sweden
"Do we Need a biological definition of ARDS"

- Berlin definition has NO Diffuse alveolar damage .
- the Berlin defn does not capture well
Frohlich - different definitions specificity of 0.63, 0.42, 0.31 even!
#ventilation #ards #LIVES2022
academic.oup.com/bja/article/11…
The BJA article by Frohlich.
Fibrosis only starts after 7 days
Thille article : atsjournals.org/doi/full/10.11…
In essence, different disease processes are happening to the lung at different times in the "ARDS"
pubmed.ncbi.nlm.nih.gov/24429204/
Read 14 tweets
Oct 25, 2022
ARDS - new definition or phenotypes by @GicoBellani refreshing with Kigali definition of ARDS - useful not just low resource but during pandemic in supposedly high income settings and only draw back is no PEEp requirement #ards #ventilation #LIVES2022 @ESICM
@GicoBellani @ESICM Resolved versus confirmed ARDS
- prospectively applying Berlin definition did work but if ya wait 24 hrs and re-measure P/F ratio, you end up stratifying much better.
- Better separation of groups

pubmed.ncbi.nlm.nih.gov/29632996/
#ventilation #LIVES2022
@GicoBellani @ESICM Whichever definition - american european consensus or Berlin or Kigali -- all goes back to Ashbaugh original paper in 1967

thelancet.com/journals/lance…

Why are we so confused when it comes to ARDS definition ?

#ards #ventilation #LIVES2022 @ESICM
Read 12 tweets
Oct 25, 2022
Next : Mypinder SEKHON on cardiac arrest in COVID-19 era.

Works in Vancouver
COVID 19 era cardiac arrest ARE a lot less sexy with all the PPE. #als #covid19 #resuscitation #LIVES2022
@ESICM
@ESICM Let's look at epidemiology. Northern Italy, Manhattan - COVID hit hard and has impact on other diseases.

e.g., OHCA in Italy during COVID 19 massive spike.
Read 9 tweets

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