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Emmanuel Profile picture
@ejustin46
Feb 22 • 11 tweets • 5 min read • Read on X
Scrolly
"After centuries of pestilence and decades of global vaccination, MEASLES VIRUS (MeV) genotypes CAPABLE of EVADING VACCINE-INDUCED IMMUNITY HAVE NOT EMERGED"

IS IT SURE ? Image
2) If we strongly recommend vaccination for measles, the question of whether the measles virus (MeV) has mutated, and requires a change of vaccine, nevertheless seems important for us. Image
3) First there was a thread from our friend @jukka235 with the example of several countries including, for example, Austria. A Country with a high level of measles vaccinations, which has not stopped vaccinating during the pandemic and is experiencing a strong outbreak
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4) Then there was this Eurosurveillance letter on a virus mutation discovered in Italy.
eurosurveillance.org/content/10.280…
Image
5) Certainly the substitution rate of MeV (left) is in no way comparable to that of SARS-COV-2 (right)
Image
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6) However, several studies have addressed the subject of MeV mutations.

"Measles Encephalitis: Towards New Therapeutics"
researchgate.net/publication/33…
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7) "Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteins"
sciencedirect.com/science/articl…
Image
8) "Collective Measles Virus Mutations Linked to Fatal Encephalitis"
genengnews.com/news/collectiv…
9) "Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors"
ncbi.nlm.nih.gov/pmc/articles/P…
Image
10) and to end, an interesting article :

"Study reveals how measles virus mutates and spreads in the human brain"
news-medical.net/news/20231221/…
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11) If the hypothesis of the re-emergence of measles following the weakening of the immune system linked to multiple reinfections with SARS-COV-2, possible mutations of MeV remains in our opinion, a plausible hypothesis, to be followed.

Thanks for reading 🙏 Image

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More from @ejustin46

Emmanuel Profile picture
Feb 24
AVOID REINFECTION 🙏

LONG-TERM RISKS of RESPIRATORY DISEASES in patients INFECTED with SARS-CoV-2

"3 cohorts were included in this study; 112,311 individuals in the COVID-19 group, 359,671 in the contemporary group, and 370,979 in the historical group" thelancet.com/journals/eclin…
Image
2) "Individuals who survived the first 30 days of COVID-19 exhibited an increased risk of asthma HR 1.49; bronchiectasis HR 1.30; interstitial lung disease HR 1.81; lung cancer HR 1.39 ..." Image
3) Fig. Cumulative hazards of incident respiratory outcomes in COVID-19 group (A) Asthma outcome; (B) Bronchiectasis outcome; (C) Chronic obstructive pulmonary disease outcome; (D) Interstitial lung disease outcome; (E) Pulmonary vascular disease outcome; (F) Lung cancer outcome Image
Read 6 tweets
Emmanuel Profile picture
Feb 24
RNA DETECTION and PERSISTENCE in BODY FLUIDS associated with SEXUAL ACTIVITY (saliva, semen, vaginal secretion, urine and faeces/rectal secretion).

INCLUDED STUDIES : A total of 182 studies with 10 023 participants. bmjopen.bmj.com/content/14/2/e…
Image
2) RESULTS
"The combined proportion of individuals with detection of SARS-CoV-2 was 82.6% in saliva, 1.6% in semen, 2.7% in vaginal secretion, 3.8% in urine and 31.8% in faeces/rectal swabs Image
3) The maximum viral persistence for faeces/rectal secretions was 210 days, followed by semen 121 days, saliva 112 days, urine 77 days and vaginal secretions 13 days. Culturable SARS-CoV-2 was positive for saliva and faeces."

Thanks for reading 🙏
Read 5 tweets
Emmanuel Profile picture
Feb 23
AMAZING SCIENCE ARTICLE !

A SPIKING FEVER
Long neglected, LASSA FEVER is surging in West Africa. Researchers want to know why

In September 2023, 13-year-old Ngozu Ofozor was preparing to go home after spending 2 weeks in the Lassa Fever Isolation Ward science.org/content/articl…
Image
2) Lassa fever has long been concentrated in endemic areas in Nigeria, Guinea ... But in recent years, cases of the deadly hemorrhagic disease have been popping up in other parts of West Africa. With climate change and population growth, the virus is expected to extend its reach Image
3) Scientists isolated the virus from 14 specimens of multimammate mouse, Mastomys natalensis, so-called because of its long rows of nipples for nursing big litters.
science.org/doi/10.1126/sc…
Image
Read 11 tweets
Emmanuel Profile picture
Feb 23
CHOLESTEROL and COVID-19
Therapeutic opportunities at the host/virus interface during cell entry.
life-science-alliance.org/content/7/5/e2…
Image
2) "Targeting host factors that support virus entry, replication, and propagation provide opportunities to lower SARS-CoV-2 infection rates and improve COVID-19 outcome. This includes cellular cholesterol, which is critical for viral spike proteins to capture the host machinery Image
3) for SARS-CoV-2 cell entry.
Once endocytosed, exit of SARS-CoV-2 from the late endosomal/lysosomal compartment occurs in a cholesterol-sensitive manner. In addition, effective release of new viral particles also requires cholesterol. Image
Read 5 tweets
Emmanuel Profile picture
Feb 23
RISKS of AUTOIMMUNE DISEASE after COVID-19 ! 😨

Results: A total of 3,908,592 patients were included.
"Cutaneous vasculitis, polyarteritis nodosa and hypersensitivity angiitis had the highest risk ratios frontiersin.org/journals/immun…
Image
2) Overall, psoriasis, rheumatoid arthritis, and type 1 diabetes had the highest incidence during the study period, and of these, psoriasis and diabetes were more likely after COVID-19."

Fig. Adjusted risk ratio for autoimmune disease within 1 year after COVID-19 vs. no COVID-19 Image
3) Table 3 : Risk of autoimmune disease by positive antinuclear antibodies (ANAs) status. Image
Read 4 tweets
Emmanuel Profile picture
Feb 23
LONG COVID
How SARS-COV-2 "SEEDS" INFECTION from BONE MARROW to the PLATELETS?
(layman terms) Image
2) Bone marrow plays a vital role in the immune system by producing various types of cells. The production of immune cells is essential for maintaining an effective immune response to protect the body and unfortunately these cells in bone marrow are infected by the SARS-COV-2 Image
3) SARS-COV-2 infects macrophages present in bone marrow using a receptor other than ACE2, Neuropilin-1
(We will come back in another thread on the different entries of SARS-COV-2 into cells which cannot be limited to ACE2)
biorxiv.org/content/10.110…
Read 9 tweets

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