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Emmanuel Profile picture
@ejustin46
May 14 โ€ข 6 tweets โ€ข 3 min read โ€ข Read on X
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๐™‘๐™„๐™๐™๐™Ž๐™€๐™Ž ๐™‡๐™Š๐™‘๐™€ ๐™๐™Š ๐™๐™๐˜ผ๐™‘๐™€๐™‡ !

In 2 months, 10 SARS-COV-2 variants + 9 others pathogens detected in wastewater from aircraft and airport terminals at Singapore Changi Airport, Jan-Feb 2023
medrxiv.org/content/10.110โ€ฆ

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2) The study investigated the feasibility of monitoring SARS-CoV-2 and other pathogens in wastewater from aircraft and airport terminals at Singapore Changi Airport between Jan-Feb 2023.
SARS-CoV-2 and variants were detected in wastewater from both aircraft and airport terminals. Image
3) Several variants of interest were detected in aircraft wastewater 18-31 days before being detected in local wastewater or clinical cases.
Viral load trends from airport terminal wastewater correlated more strongly with local COVID-19 cases rather than global cases ... Image
4) ...indicating it reflected local community infections.
Viral load trends preceded clinical case trends by 2-5 days.
Nine pathogens (5 respiratory and 4 enteric viruses) were detected in aircraft wastewater, demonstrating potential to monitor diseases beyond SARS-CoV-2. Image
5) Airport terminal wastewater yielded more detections and pathogens compared to aircraft wastewater, possibly due to combined traveller and community wastewater.
The study demonstrates the value of aircraft and airport wastewater monitoring for early detection of ... Image
6) ...infectious disease threats and trends. However, challenges remain around sampling, testing, and data sharing globally.

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More from @ejustin46

Emmanuel Profile picture
May 16
๐—ง ๐—ฐ๐—ฒ๐—น๐—น ๐—ฟ๐—ฒ๐˜€๐—ฝ๐—ผ๐—ป๐˜€๐—ฒ๐˜€ ๐—ฎ๐—ณ๐˜๐—ฒ๐—ฟ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—บ๐—ฅ๐—ก๐—” ๐˜ƒ๐—ฎ๐—ฐ๐—ฐ๐—ถ๐—ป๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐˜€

academic.oup.com/jid/advance-arโ€ฆ
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2) Researchers studied the impact of repeated vaccination on the T cell response to SARS-CoV-2 in older nursing home residents (NHR). The study examines the T cell responses in a cohort of NHR and healthcare workers (HCW) over a period of 2 years, using IFN-y ELIspot and flow .. Image
3) ...cytometry.
The results show that prior SARS-CoV-2 infection and female sex are associated with higher T cell responses in NHR but not in HCW. Image
Read 4 tweets
Emmanuel Profile picture
May 15
๐—œ๐—ฑ๐—ฒ๐—ป๐˜๐—ถ๐—ณ๐—ถ๐—ฐ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ผ๐—ณ ๐—ถ๐—ป๐—ณ๐—น๐—ฎ๐—บ๐—บ๐—ฎ๐˜๐—ผ๐—ฟ๐˜† ๐—ฐ๐—น๐˜‚๐˜€๐˜๐—ฒ๐—ฟ๐˜€ ๐—ถ๐—ป ๐—น๐—ผ๐—ป๐—ด-๐—–๐—ข๐—ฉ๐—œ๐—— ๐˜๐—ต๐—ฟ๐—ผ๐˜‚๐—ด๐—ต ๐—ฎ๐—ป๐—ฎ๐—น๐˜†๐˜€๐—ถ๐˜€ ๐—ผ๐—ณ ๐—ฝ๐—น๐—ฎ๐˜€๐—บ๐—ฎ ๐—ฏ๐—ถ๐—ผ๐—บ๐—ฎ๐—ฟ๐—ธ๐—ฒ๐—ฟ ๐—น๐—ฒ๐˜ƒ๐—ฒ๐—น๐˜€

frontiersin.org/journals/immunโ€ฆ
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2) The study analyzed plasma biomarker levels in 101 individuals with long COVID to identify different inflammatory profiles.
Unsupervised clustering revealed three inflammatory clusters: a limited immune activation cluster, an innate immune activation cluster, and ... Image
3) ...a systemic immune activation cluster.
The innate immune activation cluster was associated with older age and higher BMI. The systemic immune activation cluster was associated with older age and higher vaccination rates.
Read 6 tweets
Emmanuel Profile picture
May 15
๐—ฃ๐—ฟ๐—ฒ๐˜€๐—ฒ๐—ป๐—ฐ๐—ฒ ๐—ผ๐—ณ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ฅ๐—ก๐—” ๐—ถ๐—ป ๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐˜€๐˜‚๐—ฟ๐˜ƒ๐—ถ๐˜ƒ๐—ผ๐—ฟ๐˜€ ๐˜„๐—ถ๐˜๐—ต ๐—ฝ๐—ผ๐˜€๐˜-๐—–๐—ข๐—ฉ๐—œ๐—— ๐˜€๐˜†๐—บ๐—ฝ๐˜๐—ผ๐—บ๐˜€ 2 ๐˜†๐—ฒ๐—ฎ๐—ฟ๐˜€ ๐—ฎ๐—ณ๐˜๐—ฒ๐—ฟ ๐—ต๐—ผ๐˜€๐—ฝ๐—ถ๐˜๐—ฎ๐—น๐—ถ๐˜‡๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐Ÿ˜จ

onlinelibrary.wiley.com/doi/10.1002/jmโ€ฆ
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2) This case-control study investigated the presence of SARS-CoV-2 RNA in plasma, stool, urine, and nasopharyngeal samples in previously hospitalized COVID-19 survivors with (n=57) and without (n=55) persistent post-COVID symptoms, on average 27 and 26 months ... Image
3) ...after infection respectively. No viral RNA was found in plasma, stool, or urine of those with ongoing issues. SARS-CoV-2 RNA was detected in 3/57 nasopharyngeal samples (5.25%) of the symptomatic group but none in the asymptomatic controls, implying potential reinfection ..
Read 4 tweets
Emmanuel Profile picture
May 15
๐™Š๐™ฃ๐™š ๐™ค๐™› ๐™ฉ๐™๐™š ๐™ข๐™–๐™ž๐™ฃ ๐™š๐™ฃ๐™ฉ๐™ง๐™ฎ ๐™ฅ๐™ค๐™ž๐™ฃ๐™ฉ๐™จ ๐™›๐™ค๐™ง ๐™ƒ5๐™‰1 : ๐™„๐™๐™„๐™๐™ˆ3

(๐˜ฃ๐˜ข๐˜ค๐˜ฌ ๐˜ต๐˜ฐ ๐˜ข ๐˜ค๐˜ฐ๐˜ฎ๐˜ฑ๐˜ญ๐˜ฆ๐˜ต๐˜ฆ ๐˜ด๐˜ถ๐˜ฎ๐˜ฎ๐˜ข๐˜ณ๐˜บ ๐˜ต๐˜ฉ๐˜ช๐˜ด ๐˜ด๐˜ต๐˜ถ๐˜ฅ๐˜บ ๐˜ต๐˜ฉ๐˜ข๐˜ต ๐˜ธ๐˜ฆ ๐˜ฑ๐˜ฐ๐˜ด๐˜ต๐˜ฆ๐˜ฅ 1 ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ต๐˜ฉ ๐˜ข๐˜จ๐˜ฐ)
biorxiv.org/content/10.110โ€ฆ
Image
2) Interferon-induced transmembrane protein 3 (IFITM3) is an innate immune protein that is upregulated during viral infections and restricts a variety of enveloped viruses, including influenza virus. Image
3) There are common genetic variants in the human population that negatively impact IFITM3 expression and activity. These IFITM3 deficiencies have been linked to more severe influenza virus and SARS-CoV-2 infections in humans. Image
Read 7 tweets
Emmanuel Profile picture
May 15
๐™ƒ5๐™‰1 ๐™ƒ๐™ช๐™ข๐™–๐™ฃ ๐™ฉ๐™ค ๐™๐™ช๐™ข๐™–๐™ฃ ๐™ฉ๐™ง๐™–๐™ฃ๐™จ๐™ข๐™ž๐™จ๐™จ๐™ž๐™ค๐™ฃ ?

"The study only found strong support for human transmission of the virus when a single large cluster was included in the transmission model"
journals.plos.org/plosone/articlโ€ฆ
Image
2) The study analyzed 177 cases of H5N1 avian influenza infection from 113 sporadic outbreaks and 26 cluster outbreaks in Indonesia between 2005-2009. It examined transmission patterns within households. Image
3) The overall household attack rate was 18.3% and secondary attack rate was 5.5%. Risk of infection was higher for those aged 5-17, those with direct zoonotic exposure, and those in smaller households. Image
Read 5 tweets
Emmanuel Profile picture
May 15
๐™’๐™๐™–๐™ฉ ๐™ž๐™› ๐™‘๐™„๐™๐™๐™Ž๐™€๐™Ž, ๐™˜๐™ค๐™ฃ๐™ฉ๐™ง๐™ž๐™—๐™ช๐™ฉ๐™š๐™™ ๐™ฉ๐™ค ๐™ฉ๐™๐™š ๐™€๐™“๐™๐™„๐™‰๐˜พ๐™๐™„๐™Š๐™‰ ๐™ค๐™› ๐™ฉ๐™๐™š ๐™ƒ๐™๐™ˆ๐˜ผ๐™‰ ๐™Ž๐™‹๐™€๐˜พ๐™„๐™€๐™Ž, ๐™–๐™จ ๐™ฌ๐™–๐™จ ๐™˜๐™š๐™ง๐™ฉ๐™–๐™ž๐™ฃ๐™ก๐™ฎ ๐™ฉ๐™๐™š ๐™˜๐™–๐™จ๐™š ๐™ฌ๐™ž๐™ฉ๐™ ๐™ฉ๐™๐™š ๐™‰๐™€๐˜ผ๐™‰๐˜ฟ๐™€๐™๐™๐™ƒ๐˜ผ๐™‡๐™Ž?๐Ÿ”ฅโšก๏ธ

iflscience.com/oldest-known-hโ€ฆ
Image
2) Researchers from the Federal University of Sรฃo Paulo have discovered the oldest known human viruses in Neanderthal bones that are over 50,000 years old. The viruses found include adenovirus, herpesvirus, and papillomavirus. Image
3) This finding suggests that Neanderthals could have been affected by the same viruses that affect humans today. While the viruses may not have directly caused the extinction of Neanderthals, it adds weight to the theory that viruses may have played a role in their extinction. Image
Read 4 tweets

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