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Christie Laura Grace Profile picture
@_HeartofGrace_
Aug 18, 2024 • 104 tweets • 53 min read • Read on X
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1/ A 🧵combining a bunch of 🧵s on cGAS STING and modRNA and LNP harms, including peer reviewed studies, specific injuries, with substack and podcast at the end.
"BREAKING STUDY PUBLISHED 10/17/2023: Foreign dsDNA can cause strokes via cGAS STING":

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2/ Length of the dsDNA plasmid drives strength of cGAs STING and the immune system. Cleaning it up and lowering amounts is a false statement.
Even in low amounts, longer pieces of dsDNA cause the most harm. 6/20
activatiohttps://x.com/_HeartofGrace_/status/1804274300255457685 Image
3/ T CELLS, have their OWN cGAS STING Pathway! DNA PLASMIDs can interact w/ cGAS STING OF T CELLS, causing FUNCTION of T CELLS to be: IMPAIRED, cause T CELL DEATH, IMPEDE T CELL PROLIFERATION, hindering an effective immune response, and CANCER.

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4/ STING Type III (R71H-G230A-R293Q) Common in European and Middle Eastern populations. this variation of STING has the highest prevalence of AUTOIMMUNE DYSFUNCTION AND AGRESSIVE CANCER RATES. Common in European and Middle Eastern populations.
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5/ A little map of injuries and image of a variation of STING and how that relates to mRNA NLP injuries

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6/ Another cGAS STING thread (this is not the spike protein)


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7/ CANCER: COMBINED" FEEDBACK LOOP of cGAS STING/ APOBEC: DNA plasmid in LNP +DS RNA triggers cGAS STING AND induction of DNA deaminase APOBEC3A + nuclear DNA damage: Dysregulation/feedback loops of cGAS STING meets APOBEC (DIFFERENT MULTI-HIT mechanism)

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8/ COVID JABS CAUSING MULTI SYSTEM ORGAN DAMAGE /FAILURE through (hyper) ACTIVATION/DYSREGULATION of cGAS STING pathway by interacting with DNA PLASMID contamination, SPIKE PROTEIN. (variants of STING and mutation of STING)

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9/ "Rapid Onset of Paralysis after COVID 19 Vaccination: potential cause: cGAS-STING "hyper" Activation a WITH INCREASED activation due to physiolgical differences in teenager compared to adult.
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10/
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11/ "p53 acts on the cGAS STING pathway in tumor suppression. cGAS STING has multiple roles in both driving cancer and stopping it."
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12/ There's a reason why hydroxychloroquine works with lupus and other autoimmune conditions (hydroxychloroquine works on the cGAS STING pathway).

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13/ "How plasmid DNA will track to the nucleus before it gets degraded in the cell. First it gets recognized by cGAS, ..., and actually PROTECT it from being broken down, and zip it right to the nucleus.:
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14/ cGAS STING DUOX2 and pancreatic cancer

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15/ berrant activation of cGAS STING pathway can cause neurodegeneration, leading to Alzheimer's and other neurological disorders. This is a complex process, and aggregation of proteins with amyloid structures forming is part of this pathway process.
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16/ cGAs STING during fetal development of lens


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17/ activation of the cGAS-STING pathway by POLE mutation likely contributes to advantageous survival of endometrial cancer patients with POLE mutations, as cGAS-STING pathway is associated with anti-tumor activity via stimulation of inflammatory genes

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18/ "Here is a list of many types of cells that are tied to cGAS STING. cGAS STING can be activated by pieces of DNA plasmid that exists currently as contamination in the current mRNA covid vaccines that utilizes plasmids. "

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19/ Now we tie cGAS STING to GSK-3, and the implications of disease, especially, amyloid (no spike needed!)

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20/ Our previous study found an increased accumulation of cytosolic dsDNA and expression of cGAS and STING in FLSs and synovial tissues from patients with RA. In addition, a positive correlation between the cGAS immunoreactive score"

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21/ More cgas sting interactions (like manganese)
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22/ cGAS STING pathway (DNA plasmid contamination can do this) activation and implications for prognosis, immune infiltration, and tumor metastasis in implications for prognosis, immune infiltration, and tumor metastasis

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23/ Lyme's disease and cgas sting (know anyone getting paid to do a study on this?

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24/ Brain injury, including seizures and strokes, have been recently found in studies this past year, to have involvement in activation by the cGAS STING pathway.

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25/ cGAS STING, dead box and cancer


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26/ I did this all to get sh1t on and used for a year, especially by people who pretended to be my friend and said they would help my dad. Scientists in THESE circles. Nice people.

cGAs STING injury and kidney injury link x.com/search?lang=en…
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27/ Pulmonary tumor after vaccination. cGAs STING and the lung

x.com/search?lang=en…
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28/ cGAS STING pathway: there are four different types of STING--This is dependent on race. European and Middle Eastern race share one distinct form. Africans another. Asians. And the indigenous. And within this pathway mutations exist.


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29/ impacts of the cGAS STING pathway activation with increased inflammation in hearing loss and tinnitus. The activation of the cGAS STING pathway by way of DNA plasmid contamination and the spike protein in Pfizer and Moderna MRNA vaccines...
x.com/search?lang=en…
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30/ cGAs STINg and carcinoma

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31/ cGAS STING, RA, and mod RNA injuries


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32/ cGAs STING T Cell Lymphoma after covid injection

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33/ cGAs STINg Alzheimer's


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34/ "GAS STING engages in what is called a 2:2 binding stoichiometry with DNA... two cGAS molecules bind to two DNA molecules. This is crucial for the activation of cGAS, leading to the production of cGAMP, which subsequently activates the STING

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35/ around 40 bp can still activate cGAs STING, two strands of it. That is it

No volume needed


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36/ ANCA-Associated Vasculitis after Moderna COVID-19 Vaccination (case report):
cGAS STING

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37/
How Chronic inflammatory demyelinating polyneuropathy (CIDP) is caused by cGAS STING pathway interactions--Case Studies: patients experiencing AIDP after AstraZeneca COVID vaccine.


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38/ Covid injections can cause virus reactivation, by the cGAS STING pathway. cGAS STING pathway can be activated by: DNA plasmid contamination, the spike protein, bacteria, and positive charges in the covid vaccines.


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39/ manganese activates cGAS STINg, and researchers want to add it to LNP platform

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40/ f it hasn't become painfully clear yet, one would think it is imperative regardless of situation, to do everything possible, to keep inflammation down in the body, and to not trigger the cGAS STING pathway. Repeated activation of this pathway is tied cancer. The activation itself causes genomic instability and mutations.

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41/ Cerebral venous thrombosis after COVID-19 vaccines


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42/ Role of cGAS STINg in tumor environment


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43/ cgas sting, and tumor evasion without integration


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44/ DNA Plasmid/Spike activate cGAS STING pathway, and cause progression of Adenomyosis, and other harms. (STUDY):


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45/ not only did hydroxychloroquine interfere with the ACE2 receptor according to studies, HCQ and CQ block the binding of dsDNA (should do the same with spike) to cGAS, thus attenuating the underlying activation of the STING pathway mediated by cGAMP

46/ cGAS STING Path and Genetics Edition. TL;DR: Variations in cGAS STING pathway, immune system, hormones, and genes—XX versus XY--are the reasons.

47/cgas sting again at the molecular level
48/ The cGAS-STING pathway promotes the development of preeclampsia, in pregnancy, which is dangerous to the mother and baby. Preeclampsia can impair fetal growth, decreasing supply of oxygen and can lead to preterm birth, stillbirth, or infant death. DNA plasmid pieces and spike protein can activate the cGAS STING pathway.
49/ cGAS STING Pathway Activation in the BRAIN: "cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice"


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50/ High cGAS and STING expression was associated with a higher incidence of NRAS/KRAS mutations, which are linked to poor prognosis in several cancers.


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51/ The Role of cGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention"


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52/ NO SV40 NEEDED! WHAT about MODERNA? Exactly! HMMM? There is no sv40 there. Been posting about cGAS STING since last October causing Aortic dissection, myocarditis, autoimmune, and cancer involvement.
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53/ mRNA "vaccines" contain DNA plasmid, and spike protein, which can activate a pathway--cGAS STING, and drive ONCOGENE EXPRESSION and MUTATIONS W/OUT SV40!! "cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in BREAST CANCER"

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54/ countless hours, making these threads.
If I counted them up I would probably, i dont know what

GAS STING, IS the unifying mechanism for "vaccine" injury, not just for autoimmune and cancer, but CLOTS too! Platelets and Megakaryocytes have cGAS STING activation for CLOT formation!

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55/
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56/
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57/

PHYSICAL LAB TEST ASSAY: HOW to TEST the VACCINE INJURED and THOSE who have DIED from VACCINE INJURY if cGAS STING was part of the INJURY due to SPIKE protein, DNA PLASMID PIECES ETC from AUTOIMMUNE ATTACK resulting in MYOCARDITIS, Aortic Dissection, mulit organ system failure, Cancer progression at TUMOR SITE, AutoImmmune Neuropathy, AIDP, SFN, and more: BELLBROOK LABS Transcreener cGAMP cGAS Assay directly measures cyclic GMP-AMP (cGAMP) produced by cyclic GMP-AMP synthetase (cGAS, C6orf150, 2'3'-cGAMP Synthetase). These cGAMP measurements allow researchers to effectively determine the enzyme's activity.Image
58/ Layman's terms: The cGAS STING pathway is a very complex system in our bodies that protects us from infection. It is also a part of autoimmune disorders, neurodegeneration, organ injury and failure, myocarditis, AAD, and CANCER.


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59/ Protocol to induce and assess cGAS-STING pathway activation in vitro" Perhaps some of the scientists who are doing tests on the vaccine injured, or those who have died from injuries, due to multi organ failure, myocarditis, aortic dissection, auto immune attack on any organ, on the nerves, on the brain

some people are disgusting, immoral, liars, and thieves

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60/
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61/ MYOCARDITIS: Inflammation and damage to the heart by DNA plasmid contamination and spike--activation of the cGAS STING pathway causes damage including MYOCARDITIS after COVID "VACCINATION" Transfection of the cardiomyocyte (layman's explanation at the end)
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62/ GUT MICROBIOME, and COVID: The microbiota in your gut is responsible for peripheral cGAS-STING activation, promoting resistance to systemic viral infections like COVID. If you give an antibiotic during a viral infection, you risk inactivation of cGAS STING to deal with that viral infection, systemically. Your gut microbiome is not some lone ranger just hanging out. Drinking, smoking, AND specific antibiotic use, will knock down numbers of bifidobacteria (some antibiotics, even one course will reduce for A YEAR).

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63/ There's a lot of talk right now about P53 and cancer. This is a lot of science for 4 AM. P53 degrades DNA exonuclease TREX1 via TRIM24, causing cytosolic dsDNA accumulation thus, triggering cGAS STING. Loss of cGAS STNIG activation means loss of tumor suppression. Right now, there is a small molecule that should hit the market (probably in three years give or take), that has nothing to do with a gene, that goes right in, and acts on STING, regressing colon cancer tumors from 70-90%.
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64/ cGAS STING is the primary pathway for many of the harms caused by the 💉 (outside of the genomic integration concern)


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65/ cGAS STING!!!


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66/ GAS STING Pathway Activation by DNA Plasmid Contamination, SPIKE, and LPS in modRNA "vaccines": AIDP, Myocarditis, Stroke, Aortic Dissection, and More: Overview, and Biopsy Methods for Detection. When DNA integration testing fails to produce results, this pathway, should.

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67/ All the same pathway--myocarditis, stroke, rapid aortic dissection, neurodegenration, autoimmune demylenating polyneuropathy, fbirosis, RA, IBD, and other disorders: cGAS STING pathway. The DNA plasmid contamination and SPIKE can activate and send into a feedback loop. Image
68/ Super stack on how a positive feedback loop is generated by the 💉: cGAS STING Pathway activation by DNA Plasmid Contamination, SPIKE, and LPS in modRNA "vaccines": AIDP, Myocarditis, Stroke, Aortic Dissection, and More: Overview, and Biopsy Methods for Detection.
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69/

MEGA THREAD ON MULTIPLE PATHWAYS AFFECTED BY DNA PLASMID CONTAMINATION that exists as a CpG motif, and potential negative health outcomes, depending on exposure (dose amounts unknown/duration/frequency. cGAs STING included


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67/ Recognition of DNA by cGAS is dependent on DNA length. Double-stranded DNA (dsDNA) longer than 20 bp activates cGAS, inducing dimerization of cGAS and resulting in the formation of a 2:2 DNA/cGAS complex, whereas dsDNA less than 20 bp is not able to induce cGAS dimerization and activation"

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68/ Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy" The cGAS STING pathway is activated by exogenous (from the outside) ds(double stranded) DNA.


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69/ going back to the new year time. Well before Valentines day anyways

treacherous


Autoimmune diseases can be triggered by abnormal activation of the cGAS STING pathway. There are options to inhibit the cGAS STING pathway. The cGAS STING pathway is activated by exogenous DNA. Plasmid DNA contamination in RNA "vaccines" is, considered to our cells, to be exogenous (from the outside) DNA. "Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses"Image
70/ nhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy" The cGAS STING pathway is activated by exogenous (from the outside) ds(double stranded) DNA. DNA plasmid contamination is exogenous DNA.

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71/ Activin A alleviates neuronal injury through inhibiting cGAS-STING-mediated autophagy in mice with ischemic stroke dsDNA is exogenous DNA. Plasmid DNA contamination in covid RNA vaccines is exogenous DNA. Exogenous DNA activates the cGAS STING pathway in cells.

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72/ cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium"

degusting pigs


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73/ Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats


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74/ nhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration"


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75/ Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury"


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76/
There is a clinical trial on cGAS STING with IBS in kids correlating exogenous DNA--right now. cGAS STING pathway activation by pieces of DNA that do not belong, Maybe for vaxx injured, target it as last resort?



dont you wish you could go back in time, and never ever interact or cross paths with some people, ever?

me tooImage
77/A lso, zeta potential with its impact on biodistribution, the specific molar ratio required to transfect the cardiomyocyte, the charge causing clots, remodeling the inside of the blood vessels, and the DNA plasmid causing activation of cGAS STING pathway and it's impact on so many organ systems, not to mention the cancer implications and how it satisfies the muti hit cancer theory, progressing cancer

78/ Spike protein activates the Sting pathway.


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79/

dna/rna hybrids, dna plasmid, spike, ssDNA and dsDNA, and some other things activate cGAS STING

Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer (dsDNA activates the cGAS-STING. Plasmid DNA IS dsDNA)


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80/ Nerve pain, chronic peripheral neuropathic pain, chronic central neuropathic pain, and inflammation can be caused by exogenous dsDNA interacting with the cGAS-STING pathway, resulting in a chain reaction. Plasmid DNA contamination in the RNA vaccines IS dsDNA.

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81/ Happy new Year. Time to jump right in. Do or do not--there is no try. For the science folks: Read these two in tandem: 1: "Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases" "Suppression of cGAS Activity" "Suppression of MITA Activity"



they all ignored this, including AMLOST everyone in these circles, with an exception of people who knew this was true, including a politician

two of the of the scientists even went on podcasts who knew of everything I was posting, called giradot an LNP expert, who are currently writing papers. about cgas sting while gutting me again, while another let them drag me, and watched with glee

What great peopleImage
82/ CLNICAL TRIALS ARE IN PROCESS ON THE HARMS OF EXOGENOUS DNA ON CHILDREN! "Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS)

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83/ dsDNA in💉activates "STING", and may cause: Subarachnoid haemorrhage, Hypoxia, injure mitochondria, neurodegeneration, MS, Lupus, ALS, PRION disease, brain cancer, AGS, SAVI, chronic neuroinflammation, increased tumor growth, impaired T-lymphocyte, and more.
Dec 2023
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84/ more cGAS STING


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85/ Background on cGAS–STING Pathway: Cancer cells contain high levels of cytosolic DNA. The cGAS–STING signaling axis is a major sensor of cytosolic DNA and triggers the innate immune response, leading to the production of pro-inflammatory cytokines, including type I interferons.

dec 5 Image
86/
December, 2023
Thyroid damage and auto immune is linked to dsDNA. dsDNA is found in the current plasmid DNA contamination. This is slightly different in the thyroid ( histone H2B)


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87/ Nov 26, 2023

cGAS STING pathway is activated by ds DNA ( plasmids) in cells (outside nucleus). It is complicated, and interacts with helicases, like DEAD box (DDX#) Proteins. Dysregulation in cGAS-STING pathway, like DDX41, can lead to tumor formation (cancer). cGAS STING can be mutated

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88/ DEAD BOX ! Dead box! and cGAS STING!

cGAS STING pathway is activated by ds DNA ( plasmids) in cells (outside nucleus). It is complicated, and interacts with helicases, like DEAD box (DDX#) Proteins. Dysregulation in cGAS-STING pathway, like DDX41, can lead to tumor formation (cancer). cGAS STING can be mutated


These same scientists, doc, etc told me I did not know what I was talking about here either.

THIS delayed science, actually delayed trying to warn people, by dragging me through the mud while focusing on sv40 and defamed me. I think some people do not owe just ME an apology, but to apologize to others for covering me up, slandering me, defaming me, and dragging me through the mud for over a year, it meant this info was sh1t on while they sh1t on me. How terrible!

Think about that
What great people.Image
89/his study comes in handy. The cGAS-STING pathway "sees" aberrant nucleic acids. The DNA plasmids are already aberrant in more than one way--it's bacterial, recombinant, has CpG motifs, AND, according to the study breakdown in the thread below, is being mutated inside the LNP!

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90/
The cGAS-STING pathway in humans, can detect and be activated by pieces of DNA, bacterial DNA, AND RNA (all are in the LNP!) If activated (which is outside of the nucleus), this can lead to multiple diseases, including autoimmune disease and cancer.


When these people sh1t on me, they sh1t on everything I was posting here, with malicious intent.
While people kept getting harmed, while articles were written about green monkey DNA.
Think about thatImage
91/
They all ignored it while people kept getting harmed.
DNA contamination found in c@vid vaccines IS dsDNA. Humans have a pathway called, cGAS–STING pathway. This pathway can be activated by dsDNA (PLASMID DNA), causing autoinflammatory, autoimmune, degenerative disease, and cancer.

we are now into november, 2023. The only thing being discussed was SV40 and DNA plasmids. Think about this.. dragged through media channels while people were harmed and died. I have no good words here.



What great people.Image
92/Npv 15 2023
DNA PLASMID CONTAMINATION in mod RNA "vaccines" does NOT have to enter the nucleus to cause cancer. Recent advances have now expanded the roles of cGAS-STING to cancer. Highly aggressive, unstable tumors have evolved to co-opt this program to drive tumorigenic behaviors. "The cytosolic DNA-sensing cGAS-STING pathway in cancer": can be activated by dsDNA outside of the nucleus, which can be in the form of DNA plasmid contamination, which was recently found by multiple scientists in the c@vid "vaccines", thus, causing aggressive, unstable cancer.

I was told I did not now what i was talking about, by scientists i these circles, and that I was a piece of sh1t

By doing this, that buried everything I was talking about, for a YEAR, all for the pleasure of beating someone up online

what great people

93/ oo. SAME PATHWAY (cGAS) Acute myocardial infarction is accompanied by massive cardiomyocyte necrosis and tissue inflammation. In multiple studies, it was reported this extensive cardiomyocyte necrosis is also associated with elevated circulating mtDNA

Right there. November 2023--I talked about mtDNA and myocarditis

94/
nov 15 2023


DNA PLASMID CONTAMINATION in modRNA vaccines can cause STROKES Same pathway as CANCER. IT does NOT need to enter the nucleus. cGAS-STING pathway is mediator in response to dsDNA. DNA plasmid contamination is dsDNA.

(I was told everything that was said by CR. Receipts)Image
95/ dsDNA [PLASMID CONTAMINATION IN LNP/modRNA ] CAN CAUSE STROKES via cGAS STING


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96/ rumble cgas sting (I was supposed to record something similar MONTHS ago but my friend /podcaster had a baby, which is more important,

rumble.com/v58fgjp-the-pa…
97/ cGAS STING Pathway activation by DNA Plasmid Contamination, SPIKE, and LPS in modRNA "vaccines": AIDP, Myocarditis, Stroke, Aortic Dissection, and More: Overview, and Biopsy Methods for Detection.

christiegrace.substack.com/p/cgas-sting-p…
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98/ CANCER: "COMBINED" FEEDBACK LOOP of cGAS STING AND APOBEC: DNA plasmid in LNP +DS RNA triggers cGAS STING AND induction of DNA deaminase APOBEC3A + nuclear DNA damage:

christiegrace.substack.com/p/cancer-combi…
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99/ Hydroxychloroquine! But, it's not just antiviral. Look what it is doing to cGAS!


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100/ this actually occurs via cgas sting, apobec, a couple of other things, and one mechanism I a waiting to finish writing and submit on.


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More from @_HeartofGrace_

Christie Laura Grace Profile picture
Oct 25
💉🚨 Preprint: Aldehyde Impurities in Ionizable Lipid mRNA-LNP Formulations: Mechanistic Links to Cancer Susceptibility in Genetically Vulnerable Individuals. ONE TEST ALONE COULD HAVE CHECKED FOR ALL OF THIS.
Some Aldehydes are known carcinogens. The ionizable lipids in the mRNA LNP plarform contain aldehydes. Aldehydes exist as impurities in the ionizable lipids, and are responsible for forming the adducts that Moderna found to cause almost 50% of the mRNA (found inside the LNP) to have a loss of translation--loss of spike protein made.

🦠Some have heard about researchers that looked at the N1 methyl pseudouridine used in the mRNA stating that was the cause of junk proteins being made (frame shifting, loss of translation--spike protein is already bad), but those researchers DID NOT state they used the methods that Moderna and others used to see the ionizable lipids are causing these adducts to form where the ionizable lipids are covi]alently bonding (strongest bond in nature) and effectively gluing themselves to the mRNA inside the COVID vaccine, adn that these adducts caused the junk proteins to be made. I stated this in 2023. I am saying it AGAIN. MODERNA EVEN SAW IT.

🌟To help exlpain this, the mRNA that makes spike protein has negative charges to it. The DNA plasmid contamination has negative charges to it. The ionizable lipids have a positive charge, meaning they stick together, that is one reason the companies used the ionizable lipids. The impurities which are in the form of ALDEHYDES were found to cause the adduct formation. These things are ALL inside f the COVID vaccine in the LNP.

👀In the first paper below, I highlight a concern that these ALDEHYDES could form BONDS with HUMAN proteins, HUMAN RNA, and HUMNA DNA. This means creating adducts with things in our cells--bind to them. Some of our body processes could recognize this is happening and get rid of the cell on its own where this would happen. If one of these lipids binds with a protein, it could interrupt what a protein does. if an ionizable lipid bonds with our RNA, it could interupr that process. if it manages to get in the nucleus, now we have a different set of concerns, because the positive charged lipid (and the DNA plasmid) can interact with human chromatin, and possibly bond with the DNA inside, and mutate it--no integration needed.

🚨What I addressed further, in this new paper, is that certain ALDEHYDES have been found to be of a risk for people who have certain gene variants, like BRCA2 in LOW AMOUNTS. Getting exposed to aldehydes does not mean you will get cancer, but cigarette smoke, alcohol, and other things contain ALDEHYDES.

Aldehydes are highly reactive chemicals that can attach to DNA or proteins inside our cells. Usually, our bodies have enzymes that clean up aldehydes quickly, preventing damage. But research shows that even tiny amounts of aldehydes can be dangerous in certain situations, particularly for people with genetic vulnerabilities (gene mutations).

Most people have an enzyme called ALDH2 that helps the body break down acetaldehyde, a toxic byproduct created when alcohol or certain chemicals are metabolized. But about 30–50% of people of East Asian descent and a smaller percentage of people in other groups carry a variant called ALDH2*2, which makes this enzyme work poorly. When ALDH2 doesn’t clear acetaldehyde quickly enough, even tiny amounts can build up inside cells and bind to DNA or proteins, creating what scientists call aldehyde adducts. These adducts can damage the cell’s genetic material and interfere with DNA repair one reason why people with this variant have a much higher risk of cancers in the mouth, throat, esophagus, and sometimes the breast.
This connection between inherited enzyme deficiencies and the chemistry of new drug delivery systems like the LNP hasn’t been fully explored yet. This is one reaosn I wrote this paper.

One paper was first published around 2017--researchers found small amounts of aldehydes could be carcinogenic in BRCA2 (Aldehydes Pose a Threat to BRCA2 Mutation Carriers).

BRCA2 is a gene that helps repair DNA, and even very small amounts, aldehyde can overwhelm the cell’s defenses, causing DNA damage before repair enzymes have a chance to fix it. This isn’t just a lab curiosity. It means that in cells where DNA repair is already slightly compromised, aldehydes can trigger a cascade of problems: stalled DNA replication, chromosome breaks, and potentially, cancer risk.

💉Here’s why this is relevant to LNPs:

the aldehydes in the nanoparticles are carried inside lipids that protect them from being broken down in the bloodstream. The enzymes in our body won't get to them. Once the LNP enters a cell, the aldehydes could theoretically reach the cytoplasm and even the nucleus, where DNA resides. That means they might interact with the cell’s DNA before detoxifying enzymes can clear them, much like what was observed in the BRCA2 experiments. That means damage to DNA.

It’s important to stress that these findings are based on chemical and cellular studies, not evidence of harm in people. But they do highlight a concept called genetic vulnerability which means that some individuals carry gene variants that reduce their ability to clear aldehydes or repair DNA. In these people, even very low exposure to reactive aldehydes could be more risky.

BRCA2 mutations are known for increasing cancer risk in several organs, not just breast cancer, but primarily epithelial tissues. Based on research and clinical data, the main associations are breast cancer, ovarian cancer, pancreatic cancer, melanoma, prostate cancer, and other areas.

BRCA2 is not the only concern when it comes to ALDEHYDES.

🧬P53

Our DNA has a guardian and that is called p53, a protein that monitors damage, halts the cell cycle, and triggers repair or cell death. But when p53 is mutated, which is found in half of all cancers, this protection is lost.

Aldehydes, like acetaldehyde from alcohol, are highly reactive molecules that can damage DNA. Normally, ALDH2 detoxifies them, but people with the ALDH2*2 variant clear them poorly, letting DNA-damaging aldehydes accumulate.

These molecules can create mutations in TP53, especially at critical hotspots, amplifying cancer risk in tissues like the esophagus, breast, and throat.

Cells also rely on this other thing called the Fanconi anemia (FA) pathway to repair complex DNA damage, including aldehyde induced interstrand crosslinks. When FA function is compromised, or ALDH2 is deficient, DNA lesions persist, replication stalls, and chromosomal instability rises creating a perfect storm for mutations and cancer.

Aldehydes can react with other genes too--which I wrote about in this paper.

Some people might have different mutations at the same time, and sometimes these cluster, and have nothing to do with one another, and sometimes they do.

This is not saying anyone is getting cancer from these ALDEHYDES that are present in the ioniazble lipids, this is showing yet another ignored area of risk, that the FDA, TGA, EU, and other countries ALL AROUND THE WORLD IGNORED.

one does nto get to say "they totally did not think about the dna plasmid inside the lipid" or "they totally did not think about the adducts". one does not get to say the FDA or anyone else "totally did not think about the aldehydes in the LNP"

If you're gonna claim expert status and work for the FDA or anyone else, it should not have to be pointed out to you by a scientist typing on social media.

Again, our bodies usually clear aldehydes, but some people with certain gene variants can be more susceptible to harm. The aledhydes in the LNP are not being inhaled or drank, where we have some processes to help get rid of them--they were direcrly injected in to the human bodiy. The studies show that the impurities (aldehydes) increase with storage time, and temperature, meaning there are more of them most likely than what they find at first when they make them, and as the modRNA gets warmer, the lipids break down MORE, and cause MORE aldehydes to form.

ICHm7 guidelines for drugs and gentoxicity that the FDA and others are supposed to follow have rules on gentoxocity tests, adducts, aldehydes, and other concerns.

It is interesting that PFIZER and Moderna did not show that they tested their LNP and full product on cells that divide rapidly. Moderna used outdated legacy tests and placed the ionizable lipid next to a non dividing cell at rest, a PBMC that won't even blink at the ionizable lipid, it cannot go inside of it without the full LNP, and that is what they submitted for their "proof" of genotoxicity testing.

It is also interesting that ICH M7 clearly discusses in their guidelines this test called the HPRT (hypoxanthine-guanine phosphoribosyltransferase) assay that is used in actively dividing mammalian cells to detect point mutations, chromosomal rearrangements, and replication stress caused by reactive aldehydes or other DNA damaging agents.

If HPRT testing had been applied to cells exposed to LNP derived aldehydes or linearized plasmid DNA, it could have revealed if these things inside the LNP increased mutation rates or other concerns, but none of the companies did that, adn the FDA and other countries just said it was all OK.

Heavy science says that the HPRT assay detects mutations in a specific mammalian gene, HPRT, which is essential for purine salvage. Cells with HPRT mutations survive in media containing toxic purine analogs, allowing researchers to measure mutation frequency. Because it uses actively dividing mammalian cells, it can capture point mutations, chromosomal changes, and replication errors caused by reactive aldehydes or DNA damage which are effects that bacterial tests like the Ames assay often miss.
In simpler terms, The HPRT test looks for DNA mutations in normal mammal cells. If the gene mutates, cells survive a toxic chemical, so researchers can count mutations after being exposed to something.

Moderna did not do any test that we know of that was relevant for checking for adducts forming, or mtuations, and we have not seen if Pfizer did either.

The PBMC does not actively divide, and that is what Moderna submitted with the ames test to regulators. They used PBMCs which are immune cells, not dividing to "show" that the covid vaccines are not capable of harming genes, but the lipids on their own, cannot even get inside, they need the full LNP for that.

And as we have seen, the FDA points fingers at the drug companies, and the drug companies point fingers back at the FDA.

If you have the emans, and the funding, one does not need to get animal tissues, or particiapants in a study to check this. Get some vials of mRNA, and some dividing cells like the HPRT assay and show that adducts are forming or not. Show that mutations are hapepning or not in people. You do not need a large cohort testing for 100 things--you just need to test this ONE thing.

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Would you allow aldehydes to be injected into you, right into your cells, hitching rides on the mRNA and the DNA plasmid?
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Sep 9
🚨💉NEW PREPRINT! MODERNA found IMPURITIES in the IONIZABLE LIPIDS in modRNA/ LNP COVID "vaccines" are COVALENTLY BONDING to the modRNA, forming ADDUCTS lab tests. WHAT they DID NOT EXPLORE, is that THIS SAME BOND, CAN OCCUR with HUMAN RNA/DNA/PROTEINS=POTENTIAL GENTOXIC.

This is a very long read, and it MUST be. The link to the paper is below. I will be uploading a second version to correct some small grammatical errors and update on the shielding concerns, and other interactions.

In 2023 I made a thread on this, which I linked up to, and I presented this information at the Covid Conference with Dr. McMillian, Charles Rixey, Stephanie Seneff, Dr McCairn and others, and it was largely ignored despite many views.

Layman's terms first.

🔵The picture of the COVID modRNA LNP is below.

♨️The PEG on the outside of the LNP hides it for a time from the immune system of the human body, so it travels all over without being detected, and gets into cells.

Studies have shown this can last for days in the body before the immune system discovers it.

⚫️The DSPC is there for "stability", and so is the cholesterol.

⏺️There are two other types of lipids that are called IONIZABLE lipids. SOME already have a charge--this charge is a POSITIVE CHARGE, called cationic (+) and the other ionizable lipids are neutral and waiting to GAIN a charge when they enter the cells of the human body.

🔶Internally, the ORANGE lines represent the modified RNA, which are approximately 2-3 pieces per LNP. These things carry the instructions, the blueprint, for cells in the body to make (express) the COVID spike protein in the human body. When the LNP enters the cells, that is called "transfection" and when the protein is made, that is called "expression".

The APPROXIMATE molar ratio of lipids in the lipid nanoparticle (LNP) formulations used for Pfizer-BioNTech and Moderna COVID-19 vaccines is as follows:

⏺️Ionizable lipid: 50

⚫️DSPC (helper lipid-): 10

🔵Cholesterol: 38.5

♨️PEG2000-DMG (PEGylated lipid): 1.5

That means the ionizable lipids are making up about HALF of the molar ratio (weight will be shown soon).

🧬We also know that there is DNA BIOTECH plasmid containing various parts to it, including promoters that make it do it's job in E Coli when they are using it to generate the RNA in the drug labs, and Pfizer's plasmid contains the SV40 promoter.

The Mod RNA and pieces of DNA BIOTECH plasmid have what is called a phosphodiester backbone, which is HIGHLY NEGATIVE CHARGED (-). In the photo below, you can see the CHARGED IONIZABLE lipids clustered around the orange pieces of modRNA because positively charged things and negatively charged things are attracted to one another.

There are other ionizable lipids that are there, and again, they have not GAINED their positive charge yet (protonated) and when they enter the cells of the human body, THEY WILL.

🔬Moderna scientists, paid for by MODERNA, wanted to take a closer look at what is happening with the ionizable lipids and their interactions with the modified RNA in the LNP, and used special equipment and a process that HAS NEVER BEEN USED BEFORE TO TRACK WHAT IS GOING ON INSIDE THE LNP
called reversed-phase ion pair high performance liquid chromatography (RP-IP HPLC), although, SIMILAR tests have been done on pharmaceuticals in the past to detect the formation of ADDUCTS that have been found to occur that led to certain drugs being pulled off the market. This allowed them to see a reaction that was never before seen with these lipids and the modified RNA.

🧪The Moderna scientists found that a small number (when we talk volume and number of the ionizable lipid particles ( it will not be small anymore when you do the math in each DOSE of this stuff), contain impurities, and these impurities are causing the ionizable lipids to COVALENTLY bond--the strongest bond in nature, to the mod RNA, which altered it's function. When positively charged particles are attracted to negatively charged particles, that is electrostatic bond--like velcro--it can be undone. A covalent bond is like SUPER GLUE. If you think of the ionizable lipid like a ball of chocolate chip cookie dough, then think of the dough like the ionizable lipid itself, and the chocolate chips like the impurities.

🤦What MODERNA did not explore, is that this type of bonding is ABSOLUTELY POSSIBLE IN THE HUMAN BODY. SCIENCE IS SCIENCE.

This type of covalent bonding, if happening in the lab between the positively charged lipids can absolutely happen in the human body, although it has never been checked. It is currently untested, but organic chemistry and molecular biology concepts tells us this is absolutely plausible.

❓What does this mean, theoretically?

1⃣THE ionizable lipids CAN PROTECT THE MOD RNA AND DNA PLASMID FROM BEING BROKEN DOWN IN THE HUMAN BODY.

McKernan and others have discussed the the DNA plasmid itself is by design, more resistant to the body breaking it down by what are called NUCLEASES. Some plasmid DNA fragments are inherently more stable than RNA because they are double-stranded and have secondary structures that resist exonucleases.

If a positively charged lipid covalently or even electrostatically associates with these DNA plasmid fragments, it could shield them from degradation by nucleases--making them stay in the body longer, making them stay in the cells longer, and have more time to get to the nucleus without being broken down. But there is more.

The same is true for the modRNA. Studies have shown the modRNA can be found in human plasma and blood for at least 28 days. N1-Methyl-Pseudouridine is more resistant to degrading, but the addition of bonded lipid particles can make that process take longer, because of the science of charges.

🌟It’s mainly electrostatics and steric hindrance. Here’s how it works:

Nucleases recognize and bind to the negatively charged phosphate backbone of nucleic acids. If a positively charged lipid binds, it neutralizes or masks part of that negative charge, making it harder for the nuclease to dock efficiently.

Many lipids are bulky compared to a single nucleotide. If a lipid is attached to the DNA fragment, it physically blocks access of the nuclease’s active site to the phosphodiester bond it wants to cleave. Lipid binding can change the hydration shell or local ionic environment around the DNA, which can reduce enzyme activity, because nucleases often require a precise ionic environment to catalyze cleavage.
This means--the DNA plasmid and mod RNA can resist getting degraded not by just it's structure, but by the ADDED CHARGE TO IT.

TIME FOR SCIENCE AND BACK AGAIN TO LAYMAN's AFTER THIS: FROM THE PAPER:

⭕️1.Adductomics and the Mapping of Covalent Modifications

Adductomics is the science of mapping chemical changes/chemicals/impurities that attach themselves to the body’s core molecules like DNA, RNA, and proteins. These changes, called adducts, form when highly reactive chemicals bind tightly to these molecules through what is called a covalent bond. The covalent bond is the strongest bond in nature. Since the 1990s, scientists have developed advanced tools like mass spectrometry, high-performance liquid chromatography, and immunoassays that can detect extremely rare adducts in very small tissue samples. Taken together, the complete collection of these chemical modifications within a cell or tissue at any point in time is known as the “adductome.”

Adducts are created through predictable chemical reactions. Often, small reactive molecules from the environment, diet, medications, or even the body attack sensitive sites on DNA and proteins, and can damage them. For example, aldehydes can attach to proteins, while carcinogens like polycyclic aromatic hydrocarbons and nitrosamines can attach directly to DNA bases, and damage them. The body’s own processes can also generate reactive oxygen or nitrogen species during stress or inflammation, which can damage DNA by creating lesions like 8-oxo-guanine (which can be passed down to the next generation). Even though these events may be rare, and when adducts form they can interfere with how DNA is copied, how RNA is read, or how proteins fold and function in the human body. This interference can trigger mutations, immune reactions, or structural changes that may ultimately contribute to cancer, autoimmune disease, organ injury, or neurological disorders.

While the body has repair systems to correct much of this damage, some adducts escape repair. If they occur in critical regions of DNA, like tumor suppressor genes or oncogenes, they can directly trigger the development of cancer. DIRECTLY.

Other adducts may interfere with protein signaling, distort chromatin structure, or generate abnormal immune responses which would make the body’s immune system attack itself. Historical drug failures highlight these risks: fialuridine caused lethal liver toxicity by integrating into mitochondrial DNA; troglitazone damaged DNA and proteins in the liver; and benoxaprofen produced photoreactive adducts that killed cells. Drugs like these have been pulled from the market.

☑️1.1 Genotoxic impurities (GITs) and regulatory thresholds

Regulators like the FDA have long known that small amounts of unwanted, reactive chemicals called genotoxic impurities can slip into pharmaceutical products during manufacturing. These impurities matter because they can bind directly to human DNA and cause mutations, raising the long-term risk of cancer. To protect patients, international rules like the ICH M7 guideline were created THAT REQUIRE drug companies to identify and control IMPURITIES THAT REACT WITH OUR DNA (proteins and other nucleic acids), to test them in the lab, and make sure their amounts stay below a strict safety limit. That limit, called the threshold of toxicological concern, is typically set at 1.5 micrograms per day. If a drug contains more than this amount, the company must provide proof that the impurity is safe or lower it below the threshold. When drugs have bypassed these safety concerns, it was usually discovered after the drug had already been on the market and then the drug was pulled from human use.

The U.S. Food and Drug Administration adds another layer of oversight, requiring drug makers to detect impurities early in development using highly sensitive technologies. The FDA agrees with the international threshold approach but warns that for chemicals already known to cause cancer, or for those with structures likely to form DNA adducts, even stricter limits may be needed, meaning those amounts for safety are sometimes even lower.

✔️There is historical precedent for why this matters. Some drugs have been pulled from the market because impurities or breakdown products formed DNA adducts and triggered genotoxicity.

❗️⁉️THE FDA DID NOT REQUIRE TESTING THESE LIPIDS IN THE COVID VACCINES FOR ADVANCED GENOTOXICITY IN THE SAME WAY OTHER DRUGS HAVE BEEN TESTED IN THE PAST, AND THE FDA AND OTHER REGULATORS ALLOWED THE LIPIDS IN THE LNP BE LISTED AS EXCIPIENTS.

FAILURE

In drug manufacturing, an excipient is any substance included in a medication or therapeutic formulation that is not the active drug itself. Excipients serve supportive roles and they help deliver the drug effectively, stabilize it, improve taste or appearance, or control how it is released in the body.

🚨This risk may be higher if fragments of DNA plasmid from the manufacturing process are present, since they provide extra binding sites and are entering cells, so now the impurities are hitching a ride with the DNA plasmid wherever it goes--in our cells, tissues, in pregnant women, and if it goes to the nucleus, it can go there too. It can interact with cGAS STING pathway, can enter the nucleus with the DNA, and covalently bind to other nucleic acids it comes in contact with, LIKE OUR DNA, and interact with histones, and the DNA itself inside the nucleus of cells, without any dna plasmid integrating into the human genome, which can potentially mutate human DNA.

🚨CAN THE POSITIVELY CHARGED LIPIDS ADD TO THE DNA PLASMID ENTERING THE NUCLEUS OR ON THERE OWN IF THE POSITIVE CHARGE IS THERE WHILE BOUND TO THE DNA PLASMID? YES!!!!

STUDIES HAVE SHOWN THAT A POSIVIE CHARGE IS A NUCLEAR LOCALIZATION SIGNAL--NLS.

"The classical nuclear localization signals (cNLS)
As shown in Table 1, the cNLS encompass two categories, termed “monopartite” (MP) and “bipartite” (BP) [16]. MP NLS are a single cluster composed of 4–8 basic amino acids, which generally contains 4 or more positively charged residues, that is, arginine (R) or lysine (K). The characteristic motif of MP NLS is usually defined as K (K/R) X (K/R), where X can be any residue [17]. For example, the NLS of SV40 large T-antigen is 126PKKKRKV132, with five consecutive positively charged amino acids..."
The SV40 is NOT the large T antigen, but IT IS THE POSITIVE CHARGE THAT DRIVES IS ASSISTING TO DRIVE IT RIGHT INTO THE NUCLEUS.

‼️‼️At present, no adductomic or genotoxicity studies have been completed specifically to know. For the human body, that means we simply do not know if these impurities could cause mutations or other genetic damage. Without direct testing, their safety cannot be assumed.

❗️🔥3. Mechanistic Deep Dive of Temperature and Charge
the Arrhenius principle:

The way lipid–mRNA adducts form is not random. Two key factors drive the process: temperature and the electrical charge on the lipids. Inside the LNP itself, there are four types of lipids, and one type, the cationic lipids, are electrostatically bound to the RNA because the lipids have a positive charge and are attracted to the negative charge on the modified RNA backbone. But here’s the thing, the impurities in some of these lipids are creating A COVALENT BOND WITH THE MODIFIED RNA, MEANING IT IS PERMANENT, AND FORMING AN ADDUCT. From basic chemistry, we know that higher temperatures make chemical reactions happen faster, and this principle plays out in the modRNA vaccines. In experiments, the amount of modified RNA grew steadily as storage temperatures increased. When vaccine formulations were kept at body-like warmth temperatures, far more RNA became chemically altered than in samples stored cold or frozen. What this means is that the hotter the environment, the more the RNA instructions inside the vaccine risk being chemically damaged before they ever get a chance to work in the body.

Heat also changes the way the lipid nanoparticles behave physically. At warmer temperatures, the lipids become more fluid and mobile, making it easier for them to bump into and react with the RNA bases. These collisions increase the odds of chemical binding, and once one modification occurs, the same strand of RNA can accumulate several more adducts. This doesn’t just lower the amount of modified RNA; it creates a mix of slightly different, chemically altered RNA fragments.

CHARGE AGAIN!
Charge adds another layer to the story. The ionizable lipids in the nanoparticles carry positive charges under certain conditions (some of the lipids inside the LNP are ionizable, meaning they can gain a positive charge, while some already have a positive charge), especially at the body’s natural pH or in acidic environments.

Some of these lipids already have a charge while in the vial itself, but when others enter the body, which is what they were MADE to do, they BECOME ionized and now carry a charge when they hit lower pH in the cells, which means, there will be THE SAME REACTIVE PLACES ON THOSE LIPIDS THAT WERE NOT YET REACTIVE UNTIL THEY HIT THE HUMAN CELLS, WHICH MEANS, THERE ARE NEWLY CREATED REACTIVE IMPURITIES THAT ARE BEING REALIZED AS THE IONIZABLE LIPIDS ENTER THE CELLS OF THE HUMAN BODY, CAPABLE OF FORMING NEW ADDUCTS WITHIN THE HUMAN BODY, AND CAN REACT WITH HUMAN RNA, HUMAN DNA, AND HUMAN PROTEINS.

MORE!!!

🚨🚨🚨🚨🚨4. Hypothetical In Vivo Implications

A key question raised by the work of Packer and colleagues is whether the same chemical reactions they saw happening inside the vaccine particles in the lab might also happen inside the human body after injection. They found that certain reactive lipids—the ionizable lipids. in the vaccine can chemically (covalent bond) attach themselves to the RNA, creating an ADDUCT. The original Moderna study only looked at this effect on the mRNA inside the nanoparticles.

If these reactive lipids are still attached to the nanoparticles (they are free floating, they are attached to the modified RNA inside the COVID vaccine, and attached to the pieces of DNA plasmid contamination inside of the covid vaccine), when injected into the human body, they may continue reacting with the mRNA during circulation or once the modified RNA is released inside cells. The consequence of this is that the mRNA can no longer make protein, which has already been shown clearly in the lab.

A second possible target of the electrostatic bond and covalent bond attachment of the impurities that are like chocolate chips inside of the lipid chocolate chip cookie (poor analogy I know) is DNA plasmid fragments that have been found in COVID vaccine batches. DNA has the same kinds of vulnerable chemical sites as the modified RNA. THE REACTION SHOULD BE THE SAME, BASED ON KNOWN SCIENCE. If the reactive lipids bind to these DNA fragments, they could create new complexes, including but not limited to : DNA PLASMID ADDUCTS, HYBRID modRNA: DNA PLASMID PIECES, and weird clusters—it is NOT a ONE FOR ONE BINDING situation. If these modified DNA pieces enter the nucleus of a cell, where the cell’s own chromosomes are stored, they might interfere with normal DNA processes, and BIND to things in the NUCLEUS—INCLUDING HUMAN DNA.

🚨 Even without fully integrating into the cell’s DNA, damaged fragments could cause problems if the cell tries to repair or copy them. This is most likely in actively dividing cells, when the protective barrier around the DNA temporarily breaks down, creating opportunities for foreign genetic material to get close to the cell’s chromosomes. Another concern is cGAS STING, as cGAS STING pathway is not just sensitive and highly reactive to DNA PLASMID PIECES< IT IS ALSO REACTIVE TO CHARGE—AND IF DNA PLASMID PIECES ARE BUMPING UP AGAINST CGAS STING WITH A CHARGE—THIS MIGHT INCREASE THE IMMUNE SYSTEM REACTION EVEN MORE.

🔃Proteins in the body are another potential target. Proteins are made up of building blocks that have chemical “hot spots” the same way DNA and RNA do. Toxicology research has long shown that reactive chemicals like aldehydes and epoxides can bind to proteins, which can change their shape or disable their function. If that happens here, it could inactivate important enzymes, cause proteins to fold incorrectly (leading to stress inside cells), or create altered protein fragments that the immune system might mistake as dangerous, sparking inflammation. OUR BODY contains a large number of proteins that do different things in our body—we have motor proteins that carry things to other cells in the body—just numerous amounts of proteins.

That said, whether these reactions reach significant levels inside the body depends on several factors: how quickly the reactions happen, how concentrated the reactive lipids are, and where they end up. Inside the nanoparticles, the lipids are close to the modified RNA AND the DNA PLASMID pieces, making reactions more likely. But once released into the bloodstream, these reactive species may also encounter natural “scavengers” like glutathione and blood proteins, which can neutralize them. This means their window of opportunity to damage DNA, RNA, or proteins might be relatively short. The outcome depends on whether they reach critical targets before being neutralized. HOWEVER, studies have shown that the modified RNA in the COVID vaccines is persisting in some people for at least 28 DAYS. While the N1-Methylpseudouridine has been largely pointed out to be the cause of the RNA not degrading, MODERNA has shown the some of the lipids ARE covalently bonding to the modified rna, which means the lipids attached to the modified RNA may be INTERFERING with the body’s ability to break it down too.

If these reactions do happen inside the body, even at low levels, the potential consequences could include DNA damage, activation of the body’s emergency DNA repair systems, mitochondrial stress that generates harmful free radicals leading to ROS and the potential for different types of lesions, or long-term changes in how genes are regulated. Proteins that are chemically altered could misfold or act as new triggers for the immune system. Modified RNA or DNA could set off innate immune sensors like cGAS-STING, which in turn activate inflammation pathways. These outcomes remain theoretical but are based on well-established chemistry and biology.

🚨❗️🌟CANCER QUESTIONS--COULD THESE THINGS OCCUR???

1. What the lipids are doing

The ionizable lipids are designed to bind RNA electrostatically, then release it in the cell.
But impurities (aldehydes, electrophilic fragments) can covalently bond to RNA or DNA (shown by Moderna’s adduct data in vitro).

Once a covalent adduct is made, it’s a permanent chemical modification --it's not a reversible binding.

2. Pathways to cancer (hypothetical)

Point mutations may occur ff a reactive lipid or its aldehyde forms an adduct with DNA during replication, it can mispair = mutation.

DNA crosslinking or strand breaks: might occur if some aldehyde adducts create double-strand breaks if replication forks collapse.

Epigenetic disruption is a hypoethcial concern, if Lipid adducts with DNA-binding proteins (histones, polymerases) could change chromatin packaging.

p53 targeting impact of these things= If mutations land in p53 or other guardians, repair and apoptosis fail = survival of damaged cells.

3. Dose and multiple exposures

Each dose introduces hundreds of TRILLIONS up to quadrillions of lipid molecules
If 1% are reactive, that’s still trillions of potential adducts.

With two or three doses, exposures aren’t simply additive because:
Adducts from Dose 1 may persist if DNA damage wasn’t repaired).
Dose 2 or 3 could hit the same cells again, compounding lesions.
More chances for “second hits” in already mutated cells or pre-cancerous lesions.

🚨❗️FDA and ICH M7 R2

Are these impurities going t opass or fail the ICH standards for genotxicity?

While this is all theoretical, this is also based on known and well established scientific principles.

There is NO REASON these adducts are not forming in our cells. An immediate halt to this platform must occur and studies done (which can happen fast) even using cow's blood, human blood, with these lipids to see if this is also occurring, because if it is, then we have a QUANTIFIABLE PROBLEM HERE--ADDUCTS FORMING IN THE HUMAN BODY--ADDUCTS FORMING WITH OUR DNA, OUR RNA, AND OUR PROTEINS.

If you are a scientist with a lab, instructions are given in the paper how to detect what is happening, without using blood of someone who is injured.

Prove it WRONG. THAT is your job.

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Sep 8
💉A few weeks ago, I made a long post describing an additional concern (different than DNA plasmid) regarding the modified RNA and LNP platform and the potential for harm in the human body. That post received 200 bookmarks in less than 24 hours. I don't take back anything I said. I converted that post into a paper that should be released from the pre-print server today or tomorrow. The contaminant may violate FDA/CBER/HHS ICH M7 (R1) guidelines for the threshold of human exposure. I will post the paper with layman's terms explanation and included here and on my substack as soon as it goes live. This needs immediate review by CDC, FDA, and HHS.
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Mar 26
🚨💉🦠PREPRINT! Journal has it now. NEW theoretical MULTI AXIS MECHANSM by spike protein, SHARED DISEASE and worse between LONG C@VID and C@VID V@CCINATION via ion channel dysfunction, and AUTO ANTIBODIES TO THE PROTEINS OF THE SODIUM CHANNEL!
Short summary below👇

THIS IS THE SHARED THEORETICAL MECHANISM:

I am about to release two more papers to preprint and journals in next 24 hours on worse symptoms, clots, and cancer.

I cannot write the summary I wanted, I have to go back to writing. This is al I got.
I must get back to writing, and sleep sometime.

✅Ion channels are tiny gateways in our cells that control how ions (like sodium, potassium, and calcium) move in and out. This

is crucial for sending signals in our nerves, regulating our immune system, and keeping our cells functioning properly.

This spans ALL of our physiological processes--ALL CELLS.

When ion channels don’t work correctly— ion channel dysfunction can cause a wide range of health issues, including neurological disorders, chronic pain, and immune system problems. Mast cell. So many things--head to toe. Not just nerve symptoms. All symptoms. Clots, All of it. Vascular permeability. All of it.

I am completing deeper dive on this because there just was not enough room in the paper to do it--exact further mechanisms on organ injury and cancer. This includes but not limited to myocarditis and organ injury. Antibodies against the areas and more with dysfunction of the ion channels in tandem with cGAS STING, MACROPHAGE, ZETA PPOTENTIAL, HORMONES, GENETIC MUTAIONS, PAMPS and DAMPS, and more.

Both C@VID-19 infection and v@ccination MIGHT, theoretically, contribute to ion channel dysfunction through immune system overactivation, chronic inflammation, and the production of autoantibodies that mistakenly attack ion channels.

The cGAS-STING pathway, which detects viral threats, can become overactivated, leading to persistent inflammation and autoimmune reactions. Additionally, the spike protein from SARS-CoV-2 shares structural similarities with certain ion channel proteins, which may lead the immune system to mistakenly target these channels, causing transient or chronic dysfunction. In some cases, this immune response may be self-limiting, resolving over time, while in others, it may lead to long-term autoantibody production, resulting in sustained neurological, cardiovascular, and muscular symptoms.

cGAS AMPLIFIES the feedback loops, while macrophages get dysregulated in the consumption of the charged lipids, the vessels in capillaries and arteries become permeable, clots--next paper in 24 hours will show full on mechanisms--tissue damage. The eyes, the whole body. Brain. IN SOME PEOPLE.

Can cause people to have all kinds of things getting misdiagnosed or as secondary effects. Bed bound. Death

This could if, THEORETICALLY, with severe gain of function mutations present in ion channel encoding for proteins in ion channel, cause cascade of immune system, autoantibody attack against proteins of ion channel, appear sepsis like, and cause death.

Heart attack.. SIDS. Sudden adult death.

FOR WOMEN--this paper shows that estrogen has an impact on ION CHANNELS and how that if a woman is menstruating and still has estrogen present, each month, a flare may occur, and cause worsening autoimmunity, which is not to say men have not suffered, but why WOMEN are suffering from these symptoms MORE. Could be worse all the time. Immune reaction worse. Initial injury worse.

Also, WHITE EURPOEANS and middle eastern background compared to African, Asia, and indigenous, while still suffering harms, have higher levels of STING activation due to variation in STING pathway making more susceptible to dysregulation, meaning more autoimmunity and harms than others in white and middle eastern background.

ALSO--women have dysregulation in gut brain axis due to estrogen.

Due to their role in nerve signaling, muscle function, immune regulation, and cardiovascular stability, dysfunctional ion channels can lead to widespread symptoms, including
SFN LIKE symptoms, AIDP LIKE symptoms. GBS like symptoms, transverse myelitis,
tachycardia, bradycardia, palpitations, arrhythmias, hypotension, hypertension, dizziness, fainting, syncope, chest pain, blood pooling in the legs, poor circulation, orthostatic intolerance, POTS-like symptoms, brain fog, migraines, chronic headaches, vertigo, tingling, numbness, neuropathy, tremors, muscle weakness, myoclonus, ataxia, seizures, hypersensitivity to light and sound, temperature dysregulation, fatigue, autonomic dysfunction, memory problems, difficulty concentrating, muscle cramps, muscle spasms, muscle stiffness, twitching, myopathy, exercise intolerance, paralysis episodes, myalgia, difficulty swallowing, loss of fine motor control, nausea, vomiting, bloating, diarrhea, constipation, gastroparesis, IBS, abdominal pain, acid reflux, swallowing difficulties, shortness of breath, hunger, hyperventilation, irregular breathing, chest tightness, chronic cough, respiratory muscle weakness, hormonal imbalances, ovarian dysfunction, irregular periods, amenorrhea, infertility, PCOS, thyroid dysfunction, insulin resistance, unexplained weight loss or gain, frequent urination, bladder dysfunction, incontinence, difficulty urinating, interstitial cystitis, kidney dysfunction, chronic inflammation, autoimmune disease, increased susceptibility to infections, mast cell activation syndrome, histamine intolerance, allergies, skin rashes, hives, anxiety, panic attacks, depression, mood swings, irritability, insomnia, hypersomnia, depersonalization, derealization, heat intolerance, cold intolerance, excessive sweating, lack of sweating, lightheadedness, vision disturbances, difficulty adjusting to light changes, tinnitus, and sensitivity to sound, smell, or touch.

This is NOT the complete list!

Organ injury, hypo or hyper thyroid like symptoms--that whole list on the Pfizer data dump: run through them. Specific ion channels are 4--also acetylcholine channel.

The cGAS-STING pathway detects foreign or self damaged DNA inside cells, triggering an immune response.

When SARS-CoV-2 infects cells or lingers as viral remnants, it can overactivate, leading to prolonged immune responses that may mistakenly target self-proteins, including ion channels. This process can contribute to autoantibody formation against ion channels, which may explain persistent symptoms following COVID-19 infection or, in rare cases, vaccination. THIS is combined with macrophage polarization and spike protein on ion channels-theoretical.

Because the spike protein shares structural similarities with certain ion channels, the immune system may temporarily mistake ion channels for the virus, leading to transient dysfunction. In some cases, once the immune system resets, symptoms resolve. However, in other individuals, this misdirected immune response is chronic, leading to persistent autoimmune-mediated ion channel dysfunction.

This could explain why some individuals experience long-term neurological, cardiovascular, or muscular issues after infection or vaccination.

This does not say that sv40 and biotech plasmids with other properties of spike are not present. This paper could not address that and does not discount.

Add in dna plasmids amplifying cgas sting and macrophage and charged lipids impacting further, and recipe for disaster.

The possibility of transient versus chronic ion channel dysfunction due to cGAS-STING activation and autoantibodies is URGENT need for testing for ion channel autoantibodies in individuals experiencing post-COVID or post-vaccine symptoms.

Identifying these autoantibodies could lead to better-targeted treatments, distinguishing between cases that may resolve over time versus those requiring immunotherapy. Research into the mechanisms behind autoimmune ion channel dysfunction will be crucial for improving diagnosis and treatment options for those affected by these complex conditions.

There is current drugs present that cost under ten dollars for ion channel dysfunction like tegretol. I am not a medical doc and this is not treating or DXing anything. Always check with your doc.

People are suffering spread the word. This is theoretical.

For those with labs, get testing!!!!

I have to go now and write.
I am ONLY answering emails and calls right now form doctors I am arranging meetings with. If you have questions, ask the experts in your circles.

I cannot chat about this or answer questions. If you want summaries, load into grok or whatever you choose. I must go.

I have work to do and messaging slows me down.Image
2/ The cGAS-STING Pathway, Ion Channel Dysregulation, and Immune Responses: Implications for Autoimmunity, Inflammation, Long COVID, and Post-Vaccination Responses

osf.io/preprints/osf/…Image
@drdrew
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@JohnBoweActor
@DiedSuddenly_
@SenatorRennick
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People told me to wait-I cannot. I am writing fast and two more are coming in 48 hours.
@RepThomasMassie

@TheChiefNerd

@EthicalSkeptic

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@Pinzie
Read 12 tweets
Christie Laura Grace Profile picture
Feb 24
1/ 🚨💉🧬 Hot off the presses, March 2025, almost one year later, "next gen mRNA"

"CpG ODN-adjuvanted, alum-adsorbed, virus-like particle (VLP) vaccine displaying the hexaproline stabilized Spike (S) protein and the Nucleocapsid, Membrane, and Envelope proteins of SARS-CoV-2." Image
2/

(This requires access, so I will screen shot) sciencedirect.com/science/articl…Image
3/ The sentence reads like a nightmare to me: " CpG ODN-adjuvanted, alum-adsorbed, virus-like particle (VLP) vaccine displaying the hexaproline stabilized Spike (S) protein and the Nucleocapsid, Membrane, and Envelope proteins of SARS-CoV-2."
Read 29 tweets
Christie Laura Grace Profile picture
Feb 23
The material that has gone into humans is research grade at best. That means RG. Fit for animals but not humans.
I dare say it was even fit for animals.

I know because it was my job.

I know the difference between research grade, cGMP (which still has its issues, One just need to research any 483 form with the FDA, or having worked designing the stuff).

I designed recombinant proteins custom, fusion proteins with specialty RNA, lipids, custom work for those who have suffered from genetic disease and cancer.

Those are small batches for clinical trials that are highly filtered by expert teams with all eyes on every vial, clean as can be, with small cohorts of maybe a few dozen people, and a liter of material. And with all that, there is still side effects because that platform is flawed on multiple levels. I can cite study after study right now on the reasons why it that is, and to pull them all from my profile, and so could others.

Sludge was allowed to be injected into over 5 billion people.

Non-coding RNA can cause cancer. Fact.

Multiple studies including done by experts who out rank anyone here in the US or the UK over in Korea have done the tests stating that the modified RNA is breaking inside the LNP. This renders it non coding, which means it can't make anything and it's only function is going to be to interfere with other cellular mechanisms with the concern of causing cancer. It can cause transient concerns which can activate pathways regardless if it is degraded in the cells.

The lipids themselves have been used in multiple studies injected into animals and have been found to cause disease and cancer because of the disruption of the continual injection and what damage has occurred as a result of exhaustion of the mononuclear phagocyte system. That's something you are not familiar with and what I'm stating here is not known to most people reading this.

Positively charged lipids have an impact on cellular function and if they aggregate an areas they can do damage.

The modified RNA has been shown to have oncogenic properties.

This modified RNA also has been known to frame shift inside the ribosome causing junk proteins to be made which is irrelevant because....

Moderna did their own study with their own researchers only a couple of years ago which they paid for using special equipment and they found (packer et Al 2021) that the impurities in the positively charged lipids are covalently bonding to any nucleic acid they come in contact with including the modified RNA inside the lipid nanoparticle creating what is called an adduct and it is occurring in about 10 spots per piece of RNA in each of the particles which, will cause the same issue and cause the slippage in the ribosome causing non-coding issues which means we're back to the cancer possibility with the junk protein being made with aggregation and misfold of a spike protein that is already known to have amyloid properties related to neurodegenerative disease.

The lipid nanoparticle itself contains high levels of the original starter biotech plasmid which was housed in e coli and grown up to make the modified RNA. On this piece of plasmid which is circular which you can look up anywhere, It contains multiple parts and the one moderna used is slightly different than the one Pfizer used. There is a spot for the protein gene of interest. I can show you a video of you would like and you are a smart guy and it was done by a biotechnology student. There's also an antibiotic resistant gene, And a few other sections and on the Pfizer plasmid there is what is called the SV40 promoter which is minus the large T antigen However is still a very strong promoter. The CMv promoter also a strong promoter.

These are circular and they were not digested properly or removed from any of the batches and it all went into humans.

The scale of harm that could theoretically be on deck is unlike anything our civilization has ever seen when it comes to the potential harms.

I've heard people say they don't want to scare people.

The amount of cancer and autoimmune around myself and others is staggering. People in their 30s at my clinic have cancer. People in their twenties. 17-year-olds with brain tumors. A 9-year-old boy just got taken to the children's hospital here a couple months ago with myocarditis right after... Guess what?

That promoter can have transient expression in ways I'm not typing here because I'm writing a paper on it and when it's shown exactly what it is doing in cells aside from its other activity and how it can interfere with the proteome, in ways that people are not currently checking which will take time and sales turn over and the proteome is going to start replacing and making adjustments and fusion proteins are going to start to occur in some people (if they aren't already.... Fusion protein is often present in lymphoma, piers).

Then we have the issue with biodistribution and they lied about the whole thing including studies that prove more than once with full data to back peer-reviewed that the particle itself has a different biodistribution in pregnant animals compared to non-pregnant animals that it goes to the lymph nodes 8 times more and that means everything is going to the lymph nodes eight times more including eight times the spike protein eight times the RNA 8 times the positively charged lipids eight times the DNA plasmid contamination and any other god-awful contamination that exists that we know about which is occurring often like bacteria and other plasmids and cross-contamination from other projects because it is a well-known fact that this occurs and any 483 will show you this in every other plant on the planet.

This thing was never going to save anyone.

This needs to be taken very seriously.
@piersmorgan PS

I ranted that all from my phone using voice to text. I apologize for any grammatical errors
1/ plasmid dna can be taken up by a lymphocytes when injected into the muscle.

That's the biotech plasmid.

In pregnant females this happens at eight times the volume regarding lipid nanoparticles going into their lymph nodes while they are experiencing changes in their immune system but it also goes to the placenta.

Typing from my phone here

x.com/_HeartofGrace_…
Read 35 tweets

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