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Lazarus Long Profile picture
@LazarusLong13
Sep 19, 2024 • 6 tweets • 4 min read • Read on X
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"Brain on Fire" " starring Chloë Grace Moretz is on Netflix now.

It's the story of the @nypost journalist who got autoimmune encephalitis - specifically, anti-NMDAR encephalitis.

Guess what COVID can give you?

/1

netflix.com/us/title/80128…
Image
It is the most common kind of autoimmune encephalitis, hitting women at a 4 to 1 ratio.

Nice, right? It can be very difficult to diagnose, so say hello to a psychiatric diagnosis.

. ncbi.nlm.nih.gov/pmc/articles/P…
Anti–NMDA-receptor encephalitis is the most common type of autoimmune encephalitis.14 It frequently affects young women (female-to-male ratio of 4:1; median age, 21 years).14, 15
There are numerous cases documented.

Here is one.



Here are 8 more.

elsevier.es/en-revista-neu…
jneuroinflammation.biomedcentral.com/articles/10.11…

Confirmed trigger factors for anti-NMDAR encephalitis are tumours and herpes simplex encephalitis.1,2 Two studies have suggested a possible association between the HLA class I allele B*07:02 and the HLA class II allele DRB1*16:0.3 In this case, we suspect that SARS-CoV-2 infection acted as a trigger for the onset of anti-NMDAR encephalitis.
We identified eight case reports in which anti-NMDAR encephalitis (characteristic disease symptoms and detection of NMDAR antibodies in CSF) occurred with a time delay of 3 days to 3 weeks after the manifestation of COVID-19 disease (Table 1). Four of the identified 8 patients developed symptoms with a time delay of less than one week. The age of the patients ranged from 23 months to 53 years and consisted of four males and four females.
The mechanism may look like this. Diagram of mechanism.
More detailed yet👇....hit this study for even more.

Utterly fascinating.

"Just a cold" is not fascinating. I like my viruses boring and not thought of as, and I quote👇👇, "an autoimmune virus."

ncbi.nlm.nih.gov/pmc/articles/P…

Possible pathophysiology of anti-NMDAR encephalitis induced by SARS-CoV-2. During acute COVID-19 infection, viral particles, including NSP8 and NSP9, are released. The released proteins are recognized by T cells, leading to activation of B cells, which become plasma cells and produce IgM and later IgG antibodies against NSP8 and NSP9. I SARS-CoV-2-associated endothelitis and IL-17 produced by activated T cells disrupt the blood–brain barrier, allowing NMDAR antibodies to enter the CNS. IL-6 alters glial activity and initiates neutrophil granulocyte migration leading to further blood-brain b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598743/
Why do I mask? Because I don't want a brain on fire.

But you should go watch "Brain on Fire" with a friend.

But only while wearing an N95. Image

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More from @LazarusLong13

Lazarus Long Profile picture
Nov 2
Thread of debunking the myth that "babies should not be masked."

A baby uninfected is better than a baby infected.

If you oppose masking babies, you are immediately for infecting babies.

Let's get to it. A most excellent instruction page on how to mask babies. Suck it antimaskers.
This solves an equity problem.

Not everyone has the money or technical skill to build a baby buggy PAPR.

Just like not everyone has the money to buy an adult PAPR.

Are you for people on SNAP being able to protect their babies? Or not?

Most can rustle up the money to buy some uber cute baby masks!

This is the link from the baby zine.

These need to be fit tested.

Now, let's get into the good stuff. The "OMG Laz has gone too far! We've got him!"

You better bring your A game.

aliexpress.us/item/325680749…
Read 39 tweets
Lazarus Long Profile picture
Oct 22
If you are Covid Aware you have probably been avoiding the dentist. Well, the dental studies have come to you.

This edition? #CovidAwareSoReducingDentalVisits - Water flossing (WF) edition.

Or, as I like to think of it, the Gum Salon.

Thread.
Flossing is necessary for those super tight contact points as you see in the above thread, and is great to remove plaque down 1 mm deep in the gum line (gently).

InterDental Brushes are fantastic and go down 2-3 mm into the gum line to remove plaque.

And WFs in general, are, well, amazing!!

They basically go back and forth with InterDental Brushes on which is better as far as being the top of the food chain for overall cleaning of the space between your teeth.

But.

If you have gum recession, you may have this Image
Read 19 tweets
Lazarus Long Profile picture
Oct 8
#CovidAwareSoReducingDentalVisits - less mouth open = less 'vid risk.

I am a GREAT flosser. My family thought we had genetic gum disease.

Below we can see rubber stick on the left, floss on the right, and a InterDental Brush (IDB) in the middle.

See the problem?
/1 Image
A couple more example pics on why I am sick to my stomach thinking of all that money wasted.

We THOUGHT we had great dentists. Not a single one mentioned IDBs, and how the bristles allow all interdental spaces to be reached.

And it gets better!

/2 Image
Image
IDBs actually reach down in between the gum and teeth - 2-3 mm. Floss? Only 1-2 mm.

As plaque grows down into and touches your gums, that's what causes them to get inflamed - and begin to retreat (very simplified).

If you brush that space? Problem solved.

/3 Floss, Interdental Brushes, and Waterpics Use all of them - floss works great for those narrow spaces. Interdental Brushes (IDB) work great in larger spaces. Waterpics work great immediately after eating, as you want to wait for an hour eating acidic/sweet just like regular brushing. It is a mistake to NOT IDB. Multiple studies indicate IDB is good, including this RCT where IDB was better than flossing (free version - great how to brush) - with people with chronic periodontitis. Students found IDB to be better. But IDB is better than rubber picks is better than floss. IDB way better ...
Read 25 tweets
Lazarus Long Profile picture
Oct 7
Covid Aware Teeth

The Calcium Lactate Rinse. Cheap, super easy to do - and it really enhances your fluoride uptake to re-enamel your enamel.

It's just not very well known, despite being very well supported within studies - and very cheap.

Mix 1/8 tsp with 1 oz water. Shake
thoroughly, till the granules disappear. Takes a few or 20 shakes, then just wait. Rinse for 1 minute. Spit out.

Immediately brush with fluoride or fluoride rinse.

There might be a better powder
amazon.com/dp/B0DHXX9LYC?…

1/8 tsp
amazon.com/dp/B0D5LH3K1H?…

pmc.ncbi.nlm.nih.gov/articles/PMC38… Image
I use the same 1 oz shaker as my stannous fluoride rinse comes in.

(That fluoride rinse was $4 cheaper at my dentist than this $24.

My Prevident 5000 ppm actually did not need a prescription - if bought from my dentist, as a couple of side notes.)

amazon.com/3M-ESPE-PerioM…
Read 24 tweets
Lazarus Long Profile picture
Sep 18
.On the one hand, we have study after study showing 36% or so rate of LongCovid.

On the other, we have the WHO saying the rate of LongCovid is only 6%.

I got curious. What drugs are the WHO smoking - and can I get some?

🧵. Image
My 36% comes from the latest massive meta:
eatg.org/hiv-news/more-…

But what about that 6%?

Turns out it's this old chestnut from 2022.

And there are such major players on it...so many I can't even screenshot them all.

But I fear no title - and neither

jamanetwork.com/journals/jama/… Image
will you.

The problem with this 6%? There are 200+ symptoms in the LongCovid symptoms constellation.

This study focuses on three clusters.

Which is incredibly vague, which is normal for the WHO.

So, after digging through the f***ing supplement, there are a few symptoms Image
Read 10 tweets
Lazarus Long Profile picture
Sep 7
COVID is as transmissible as measles?!

"BUT, BUT, measles can infect up to 90% of people they are in contact with!"

So can COVID.

Time to wake up. The lecturer tried to promote sales of a flax oil product, and many elderly people were lured to attend by the promise of free eggs, Xinhua News Agency reported. He gave three lectures on Jan 10 and 11 in a Tonghua classroom while not wearing a mask, with each lecture lasting about 2.5 hours. A total of 97 people, most of them retirees, attended the lectures in a classroom whose doors and windows were closed, the China CDC report said. The lecturer went to a pharmacy at noon on Jan 10 due to muscle pain and other symptoms, indicating he was likely at an early stage of the disease then, it ...
weekly.chinacdc.cn/en/article/doi…

govt.chinadaily.com.cn/s/202102/20/WS… Image
So, some will be pushing back - always welcome, albeit this is anticipated.

Rnaught is just an estimate.

The famous measles 12-18 is shown below.

But the R0 of 6-8 has the most estimates.

Free
sci-hub.se/https://doi.or…

Pay
sciencedirect.com/science/articl… Image
Read 8 tweets

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