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Michal Tal, PhD Profile picture
@ImmunoFever
Oct 29 • 6 tweets • 3 min read • Read on X
1/I finally have a moment to tell you why I think there's something really huge here in @arthur_courtin's new study. Because there's this superfamily of temperature sensing proteins I'm low key obsessed with and I don't think we have given enough consideration in immune cells...
2/Your ability to feel the heat of 🌶️ capsaicin depends on a protein called TRPV1, a critical member of the TRP superfamily of proteins. TRPV1 and the other TRPs aren't just expressed on nociceptive and peripheral neurons, but also immune cells and control inflammation responses A figure about TRP protein regulation of inflammation from https://pubmed.ncbi.nlm.nih.gov/38473965/
Image
3/ Some of you may recall that the TRP protein superfamily made the spotlight with the 2021 Nobel to David Julius and @ardemp
@ardemp 4/While it's clear that the TRP proteins play an important role in host defense and inflammation, we have barely scratched the surface. You can scroll up and down in the linked thread to see some recent papers starting to explore this space:
5/TRP proteins such as TRPM3 have also been implicated in #pwME with clear implications for other infection associated chronic illnesses.
6/ TRPM3 then started popping up in Long COVID as well: frontiersin.org/journals/immun…

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More from @ImmunoFever

Michal Tal, PhD Profile picture
Oct 1
1/ The term "chronic EBV" used to elicit an🙄from many (most?) clinicians before this enormous study profiling over a million service people for decades found a causative association between Epstein Bar Virus (EBV) and Multiple Sclerosis (MS). science.org/doi/10.1126/sc…
2/ One must consider that most people are infected with EBV. For many, it would just have been one of many unremarkable "colds" without any directly associated lasting disease. Remarkably, the Bjornevik et al study found that EBV could take over a decade to trigger MS. Image
3/ EBV, like other Herpesviruses, integrate themselves into the DNA of infected cells and express just a few latency genes as they wait for the right opportunity to reactivate. (side note that JAK/STATs are important suppressors of EBV reactivation- inhibit these with caution!) table describing latency and reactivation of herpesviruses from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706188/
Read 6 tweets
Michal Tal, PhD Profile picture
May 11
One of the craziest things I learned last week at #AAI2024 was that we have more free-floating extracellular mitochondria in our blood than white blood cells. This was not in any textbook that I ever read!

And the original paper:
sci.news/biology/cell-f…
faseb.onlinelibrary.wiley.com/doi/10.1096/fj…
Wow! Thank you so much for all these interesting and thoughtful responses on all the different threads. I'm going to try to compile some of the most thought provoking ones into this thread to keep track. 2/
From @dysclinic 3/
Read 8 tweets
Michal Tal, PhD Profile picture
Feb 10, 2023
You've likely heard about gas stoves and indoor air pollution. But we don't have a gas stove. Yet, we had an indoor air pollution mystery that took me and my husband (both PhDs) 11 nights of bad air to figure out.

What the heck was going on? A 🧵 1/18
One morning in December I woke up and saw the PurpleAir (air quality sensor) bright red. A color I hadn't seen it since the wildfire smoke in California. A color I never expected to see living in the quiet suburbs of Boston. 2/
As you can see, we've had some air pollution peaks in our house before and since, all around 7pm, with thin little spikes that go quickly up and quickly back down. For a few of them I remember - I burned some brioche in the toaster, or I waited too long to stir the chili... 3/
Read 20 tweets
Michal Tal, PhD Profile picture
Sep 15, 2022
I learned something tremendous yesterday.
MENSTRUAL STIGMA is a driving force behind the tremendous diagnosis delays and lack of treatments available for gynecological diseases. This is a tremendous quality of life issue and this is something WE CAN CHANGE!!! 1/3 ImageImageImageImage
If we never talk about menstruation, those who are new to it have no way of knowing if what they are experiencing is "normal". Is it supposed to be this painful? Is there supposed to be this much bleeding? Are you supposed to still be able to focus and work and function? 2/3 Image
Perpetuating cultural taboos on topics such as menstruation and pregnancy loss has an enormous negative impact on many many people's quality of life. STOP IT NOW. Be part of the solution. Start talking and stay curious! 3/3 Image
Read 4 tweets
Michal Tal, PhD Profile picture
Aug 30, 2021
1/ Can intramuscular vaccination induce an immune response that protects against not only disease (#COVID19), but viral infection and transmission of #SARSCoV2 in the local mucosa? In a new preprint by @GeorgieNahass et al we found that saliva may be KEY🧵
medrxiv.org/cgi/content/sh…
2/ Secreted *mucosal* antibodies 💦 protect from infection or spread of infection in the mucosa of the nose 👃 and mouth 👄. *Circulating* antibodies 🩸prevent systemic infection and disease. Which antibodies do we make after vaccination? @SalivaStudy💉
3/ We measured antibodies against the #SARSCoV2 receptor binding domain (RBD) in *plasma* & *saliva* from convalescent or vaccinated individuals and tested their neutralizing potential using a replication competent rVSV-eGFP-SARS-CoV-2.

VIDEO:
#COVID19
Read 19 tweets
Michal Tal, PhD Profile picture
Jun 8, 2021
1/I've read many of your #scienceorigin stories, and after hesitating to share something so deeply personal, I've decided to because I imagine that many kindred experiences have been unfolding across the world over the last year. My #science origin story is one of loss and fear
2/that sparked a lifelong obsession with infectious disease. Before the pandemic, when I would speak to the public about the importance of vaccines, I would begin: Have you ever been afraid of something that was much smaller than you? Tiny.. so tiny you can't even see it? I am. "Vaccines are the greatest life saving device in history. Be part of the solution." My son decided to join me on stage and I gave the rest of the talk with him in my arms.
3/I think now there are so many out there who know this fear, who lost loved ones or lost part of themselves because of a tiny pathogen they never saw coming... If you encourage and cultivate all those budding young scientists, who knows what we could accomplish in the future...
Read 17 tweets

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