See? It's always been an unscientific narrative and it always will be.
2021 Jan 7
Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology pmc.ncbi.nlm.nih.gov/articles/PMC78…
March of 2021, we learned of increased TGF-b signaling.
Published: 30 March 2021
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself nature.com/articles/s4146…
November of 2021, the very protein that contributes to PAH and COPD in the HIV+ appeared at citation #20.
Published: 15 November 2021
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis nature.com/articles/s4146…
"20. Schwartz, O., Maréchal, V., Le Gall, S., Lemonnier, F. & Heard, J. M. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med 2, 338–342 (1996)."
She told everyone and they still decided to FUCK the kids, HILARIOUS!
"We also included HIV Nef as a positive control for downregulating both MHC-I and MHC-II (30, 31), and SARS-CoV ORF8a/b proteins as a negative control."
She also observed Protein E operate mechanistically as HIV's Tat which contributes to increased TGF-b signaling and CFTR silencing (not observed in ME/CFS).
"We found that in addition to ORF8, SARS-CoV-2 E, M, and ORF7a substantially down-regulated MHC-I within the cells expressing these viral proteins."
"Finally, the Tat protein of human immunodeficiency virus interacts with FBL and U3 snoRNA, impairing pre-rRNA processing and depleting mature ribosomes."
"These children reported a quality of life comparable to peers with serious illnesses like cancer or cystic fibrosis, with many expressing a deep sense of ineffectiveness and loss of confidence."
Might as well lie to children to more, not like they'll remember anything with their blob brains.
Published: 23 July 2024
Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein nature.com/articles/s4159…
Could have saved them, chose not to. Is that not the legacy of many?
HIV Tat Protein Induces the TGF-β Signaling Pathway and Suppresses the CFTR Biogenesis and Activity by microRNA-Regulated Gene-Silencing Mechanism faseb.onlinelibrary.wiley.com/doi/abs/10.109…
Could have saved them, were too MEntally ill and weak to do so.
Pathogenesis of HIV-Associated Pulmonary Hypertension
Potential Role of HIV-1 nef pmc.ncbi.nlm.nih.gov/articles/PMC31…
"The HIV-PH mechanism remains unknown, but HIV proteins such as Tat and Nef may play a role. HIV-1 Nef is a broad-spectrum adaptor protein that may affect HIV-infected and uninfected pulmonary vascular cells."
@CatchTheBaby Akiko Iwasaki told everyone to expect amyloid deposition through SR-B1 involvement and the phosphorylation of tau 217.
2023 Apr 10
Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants pmc.ncbi.nlm.nih.gov/articles/PMC10…
@CatchTheBaby "We also included HIV Nef as a positive control for downregulating both MHC-I and MHC-II (30, 31), and SARS-CoV ORF8a/b proteins as a negative control."
@CatchTheBaby Monday, January 13, 2025
NIH-funded study finds cases of ME/CFS increase following SARS-CoV-2 nih.gov/news-events/ne…
See? It's always been an unscientific narrative to suggest individuals have developed ME/CFS, hasn't it?
2022 Apr 26
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment pmc.ncbi.nlm.nih.gov/articles/PMC91…
"The most common cause of familial PD dysfunctional autophagy is associated with the expression of dominant mutants of LRRK2 (leucine-rich repeat kinase 2). LRRK2 mutations disrupt both DA neurons as well as the astrocytes."
Published: 23 July 2024
Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein nature.com/articles/s4159…
CFTR and colorectal cancer susceptibility: an urgent need for further studies cell.com/trends/cancer/…
We can thank the MEntally ill morons who drew parallels to ME/CFS for the lack of a Treatment as Prevention strategy, which accomplishes exactly what it says.
"Further, CP size increases tracked with blood levels of proteins known to increase as Alzheimer’s disease worsens, like pTau217, and with others that rise in response to brain injury, like Glial fibrillary acidic protein (GFAP)."
@raghu_venugopal Sold right up the river by those in academia, the MEdical establishment, and "advocacy" groups that drew parallels between Long Covid and ME/CFS.
@raghu_venugopal Deprived of forty years of evidenced based medicine related to HIV and left to suffer Tat-like mediated pathophysiological processes.
@raghu_venugopal Published: 30 March 2021
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself nature.com/articles/s4146…
@MeetJess "Finally, the Tat protein of human immunodeficiency virus interacts with FBL and U3 snoRNA, impairing pre-rRNA processing and depleting mature ribosomes."
@MeetJess Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders pmc.ncbi.nlm.nih.gov/articles/PMC10…