Daniel Brittain Dugger Profile picture
Jun 14 20 tweets 5 min read Read on X
I'll never forget the betrayal of my family members and take comfort in knowing you losers fucked yourselves and won't be here long, LMAO.

Go on, lie to those kids some more. Image
See? It's always been an unscientific narrative and it always will be.
2021 Jan 7
Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
pmc.ncbi.nlm.nih.gov/articles/PMC78…Image
March of 2021, we learned of increased TGF-b signaling.
Published: 30 March 2021
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
nature.com/articles/s4146…
November of 2021, the very protein that contributes to PAH and COPD in the HIV+ appeared at citation #20.
Published: 15 November 2021
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
nature.com/articles/s4146…
"20. Schwartz, O., Maréchal, V., Le Gall, S., Lemonnier, F. & Heard, J. M. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med 2, 338–342 (1996)."
2023 Apr 10
Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Akiko Iwasaki
pmc.ncbi.nlm.nih.gov/articles/PMC10…
She told everyone and they still decided to FUCK the kids, HILARIOUS!
"We also included HIV Nef as a positive control for downregulating both MHC-I and MHC-II (30, 31), and SARS-CoV ORF8a/b proteins as a negative control."
She also observed Protein E operate mechanistically as HIV's Tat which contributes to increased TGF-b signaling and CFTR silencing (not observed in ME/CFS).
"We found that in addition to ORF8, SARS-CoV-2 E, M, and ORF7a substantially down-regulated MHC-I within the cells expressing these viral proteins."
March 26, 2024
SARS-CoV-2 targets ribosomal RNA biogenesis
cell.com/cell-reports/f…
"Finally, the Tat protein of human immunodeficiency virus interacts with FBL and U3 snoRNA, impairing pre-rRNA processing and depleting mature ribosomes."
Long COVID Is Fueling a Mental Health Crisis in Children
unmc.edu/healthsecurity…
"These children reported a quality of life comparable to peers with serious illnesses like cancer or cystic fibrosis, with many expressing a deep sense of ineffectiveness and loss of confidence."
Might as well lie to children to more, not like they'll remember anything with their blob brains.
Published: 23 July 2024
Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein
nature.com/articles/s4159…Image
Could have saved them, chose not to. Is that not the legacy of many?
HIV Tat Protein Induces the TGF-β Signaling Pathway and Suppresses the CFTR Biogenesis and Activity by microRNA-Regulated Gene-Silencing Mechanism
faseb.onlinelibrary.wiley.com/doi/abs/10.109…
Could have saved them, were too MEntally ill and weak to do so.
Pathogenesis of HIV-Associated Pulmonary Hypertension
Potential Role of HIV-1 nef
pmc.ncbi.nlm.nih.gov/articles/PMC31…
"The HIV-PH mechanism remains unknown, but HIV proteins such as Tat and Nef may play a role. HIV-1 Nef is a broad-spectrum adaptor protein that may affect HIV-infected and uninfected pulmonary vascular cells."
Could have saved them, chose not.
HIV and Chronic Obstructive Pulmonary Disease
Is It Worse and Why?
pmc.ncbi.nlm.nih.gov/articles/PMC31…
"IV-infected persons might have increased susceptibility to apoptosis because the HIV proteins Tat and Nef may induce endothelial cell apoptosis."
Johnny, your mother should have named you Whitney, LMAO! Image

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More from @dbdugger

May 19
@CatchTheBaby Akiko Iwasaki told everyone to expect amyloid deposition through SR-B1 involvement and the phosphorylation of tau 217.
2023 Apr 10
Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
pmc.ncbi.nlm.nih.gov/articles/PMC10…
@CatchTheBaby "We also included HIV Nef as a positive control for downregulating both MHC-I and MHC-II (30, 31), and SARS-CoV ORF8a/b proteins as a negative control."
@CatchTheBaby Monday, January 13, 2025
NIH-funded study finds cases of ME/CFS increase following SARS-CoV-2
nih.gov/news-events/ne…
Read 31 tweets
Apr 27
Ironically, Chertow observed persistence in the basal ganglia of six individuals, the same sitting at the table.

How will the MEntally ill sacrifice them today, LMAO!!! Image
See? It's always been an unscientific narrative to suggest individuals have developed ME/CFS, hasn't it?
2022 Apr 26
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment
pmc.ncbi.nlm.nih.gov/articles/PMC91…Image
"The most common cause of familial PD dysfunctional autophagy is associated with the expression of dominant mutants of LRRK2 (leucine-rich repeat kinase 2). LRRK2 mutations disrupt both DA neurons as well as the astrocytes."
Read 30 tweets
Apr 25
It is still mindboggling anyone listens to the dumbasses who drew parallels between Long Covid and ME/CFS. Not observed in ME/CFS, is it? Image
Published: 23 July 2024
Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein
nature.com/articles/s4159…
CFTR and colorectal cancer susceptibility: an urgent need for further studies
cell.com/trends/cancer/…
Read 12 tweets
Apr 22
We can thank the MEntally ill morons who drew parallels to ME/CFS for the lack of a Treatment as Prevention strategy, which accomplishes exactly what it says.
February 10, 2026
Long COVID Linked to Alzheimer’s Disease Mechanisms
nyulangone.org/news/long-covi…
"Further, CP size increases tracked with blood levels of proteins known to increase as Alzheimer’s disease worsens, like pTau217, and with others that rise in response to brain injury, like Glial fibrillary acidic protein (GFAP)."
Read 69 tweets
Feb 16
@raghu_venugopal Sold right up the river by those in academia, the MEdical establishment, and "advocacy" groups that drew parallels between Long Covid and ME/CFS.
@raghu_venugopal Deprived of forty years of evidenced based medicine related to HIV and left to suffer Tat-like mediated pathophysiological processes.
@raghu_venugopal Published: 30 March 2021
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
nature.com/articles/s4146…
Read 24 tweets
Feb 6
@MeetJess SARS-CoV-2 targets ribosomal RNA biogenesis
pubmed.ncbi.nlm.nih.gov/38427561/Image
@MeetJess "Finally, the Tat protein of human immunodeficiency virus interacts with FBL and U3 snoRNA, impairing pre-rRNA processing and depleting mature ribosomes."
@MeetJess Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders
pmc.ncbi.nlm.nih.gov/articles/PMC10…
Read 4 tweets

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