Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
0bFuSc8 Profile picture
0bFuSc8
@0bFuSc8
4/8/15 16:23:42
Nov 20 • 5 tweets • 3 min read
1/🔁🧬The #H5N1 found in the O'ahu HI outbreak is clade 2.3.4.4b genotype A3:

➡️Genotype A3 has been been circulating in wild birds & it's detectn is consistent w/spread via migrating wild birds

➡️A3 is distinct from B3.13/cattle subclade
**Not linked to US dairy cattle outbrk Image
Image 2/➡️A3 is related to D1 (D1.1 & D1.2 seen in other #H5N1 outbrks along Pacific Flyway)
– D1.1 & D1.2 are both reassortants of A3 & North Am LPAI

➡️This doesn't mean the O'ahu outbrk is directly linked to D1 outbrks – Only that there are multiple subclades in wild birds currently Image
Image
Sep 20 • 7 tweets • 3 min read
1/📈+7 new #H5N1 affected CA herds as @HelenBranswell suspected – @CDFAnews reports +7 for a total of 17 on their page:

– All 7 herds "in a group targeted for testing due to elevated risks from their recent connections with the initial affected premises"

cdfa.ca.gov/AHFSS/Animal_H…

Image 2/🚩Locations for CA #H5N1 affected herds continue to only be disclosed as "Central Valley"

▶️NOTE: @CDFAnews is testing all herds w/in 6mi of a known #H5N1 +ive premises as well as herds w/epi links
– Good to see active case finding measures instead of waiting for Sx or…⤵️⤵️
Sep 7 • 8 tweets • 3 min read
1/⚠️@HealthyLivingMo reports 1st case of #H5 #AvianFlu in MO:
▶️Adult w/underlying conditions
▶️Hospitalized Aug 22, tested +ive for FluA
▶️Since recovered, d/c'ed home
⛔️No known animal exposure
✅#H5 detected through normal flu surveillance by MO pub health & conf'd by @CDCFlu Image 2/▶️1st case of #H5 detected via flu surveillance nationally, & not through outbreak testing

▶️Addl testing ongoing at @CDCgov – should confirm subtype (likely #H5N1 as there's no other #H5 #AvianFlu in the US)

🧬Sequencing vital to ID clade; whether this is B3.13 or not
Sep 6 • 10 tweets • 5 min read
1/🔁🧬– #H5N1 Update: – The 10 seqs uploaded to GISAID 8/31 are now also on SRA & @nextstrain – all are from cattle (locations are inferred):
▶️6 from CO
▶️3 from WY
 – 1 seq has PB2 D740N
 – 1 seq has PB2 A676V ("bulk tank")
 ***More on these⤵️***
▶️1 from ID

cc @RajlabN

Image
Image 1B/▶️The 6 #H5N1 seqs from CO group near each other

▶️The 3 #H5N1 seqs from WY also group near each other
Image
Image
Sep 5 • 8 tweets • 3 min read
1/🆕🧬Update: – Sequencing of #H5N1 from CA herds:
– Virus is 2.3.4.4b genotype B3.13
– “nearly identical” to seqs of CO herds
– This means this was NOT a new spillover
– Consistent w/spread from cattle

** But **⤵️

cc @HelenBranswell @RickABright
latimes.com/environment/st…


Image
Image 2/▶️** While it’s good news there hasn’t been a new, 2nd spillover of #H5N1 from wild birds to cattle, it’s a CLEAR indicator @USDA’s #H5N1 testing reqs are INADEQUATE (or being skirted).

⚠️If this spread was indeed due to interstate cattle mvmnt, why wasn’t it picked up >>
Sep 3 • 8 tweets • 3 min read
1/🇰🇭🆕@WHO DON on case of #H5N1 in 15yo girl in #Cambodia (died Aug 20):
– Recall, this was Cambodia's 10th human case & 2nd death

***🧬Interesting detail *** – virus confirmed to be #H5N1 clade 2.3.2.1c BUT internal genes are from H5 clade 2.3.4.4b viruses, a novel reassortant Image 2/▶️The DON states, "This novel reassortant influenza A(#H5N1) virus has been detected in human cases reported in Cambodia since late 2023."

🔗 who.int/emergencies/di…
Image
Aug 11 • 15 tweets • 6 min read
1/🔄Appreciate summary on 6 cats w/#H5N1 B3.13 from CO by Colorado Vet Med Assoc (CVMA):
– Only 1 assoc w/known infected dairy farm
– 3 = known indoor/outdoor cats; hunted mice/ small birds & spent time w/owners
– 2 = indoor only cats; Ø direct exposures

(H/t also @thijskuiken)
Image 2/➡️5 of 6 cases presented w/similar clinical signs & disease progression:
– Initial lethargy & ↓appetite
– Followed by progressive resp signs in some &
– Progressive neurologic signs in most

NOTE: – Presentation indistinguishable from rabies once neurologic signs presented
Jul 30 • 5 tweets • 3 min read
1/⚠️Wyoming, we have an #H5N1 PROBLEM⚠️
– 45 WY cattle seqs (initially shared to SRA 6/14) were re-uploaded to GenBank, now w/actual collectn date & locatn
– Collectn date = 4/29 **BUT**
– WY's 1st & only affected herd was confd June 6

@HelenBranswell @Alexander_Tin @RickABright


Image
Image
Image 2/ – This is either a mistake w/collectn date,
or WY did what OK did – collected samples from an infected herd & then SAT on them for over a month & likely only submitted them once the financial support program rolled out.

@RajlabN @cbarbermd
@HelenBranswell @RickABright
#H5N1
Jul 27 • 13 tweets • 3 min read
1/⚠️@UKHSA upgraded it's situational assessment for #H5N1 B3.13 from level 3 to 4 (of 6):
✅This clear, accurate risk assessment is appreciated

—Points I'd like to touch on:—
1⃣Onwards transmission to poultry
2⃣↑Risk of reassortment
3⃣No apparent ↓xmsn w/↑biosecurity measures
Image 1B/ ***Disclaimers:***
– This assessment describes the chance of #H5N1 B3.13 causing outbreaks in humans (in general), not the risk to specific individuals
– None of this should be taken to mean a B3.13 pandemic in humans is imminent
Jun 24 • 5 tweets • 3 min read
1/⚠️The #H5N1 detection in a cat from Harmon Co, OK is **genotype B3.13**
• There've been NO reported OK dairy herds affected
• But 10 of 12 retail milk samples processed in OK tested PCR +ive
• Only 1 detection in a wild bird in JAN this yr & none in poultry flocks



Image
Image
Image
Image 2/ Harmon Co is in southwest OK, on the border w/TX. – OK is in the central flyway & borders states that've had cattle herd detections (TX, NM, KS, CO – 3 of which had early detections)
– This cat could’ve traveled into TX & been exposed to B3.13 there (dairy herd, poultry farm…
Image
Image
Jun 9 • 7 tweets • 3 min read
1/📢@CDCgov @EIDjournal early release by @utmbhealth team responding to an early #H5N1 dairy cattle outbreak (March):
• Illness in cattle 1st seen MAR 6
•⚠️Several workers had ILI Sx, missed work MAR 4–6⚠️

wwwnc.cdc.gov/eid/article/30…
Image 1B/⚠️Workers w/ILI Sx MAR 4–6:
– Maternity worker treated for ILI Sx (Rx not specified)
– 2 milkers w/ILI Sx stayed home
– Notes "rumors of […] conjunctivitis among TX dairy farm workers"
– Ø conjunctivitis/ severe illness/ hospitalizations reported in workers from this farm
Apr 23 • 8 tweets • 3 min read
More info (some concerning) on our ongoing, multi-state #H5N1 outbreak in dairy cattle from the always thorough & informative @sciencecohen:


#HPAI
1/science.org/content/articl… 🚨 Concerning 🚨 – Vets relay anecdotes of dairy workers w/flu-like Sx who don’t not want to be tested or seen by docs.

I’m guessing there’s been a lack of clear communication w/these workers (often migrants, non-English speaking or undocumented)

@RickABright #H5N1 #HPAI
2/ Image
Apr 20 • 4 tweets • 2 min read
Good to see @CDCgov's #H5N1 update, but this isn't at all clear about (IMO much needed) surveillance in dairy farm/ other farm workers.

Epi field study/ site visit are good steps but likely not nimble enough to address the current situation.
#HPAI #AvianFlu
1/

Image
Image I rly hope the One Health Approach cited means more is in the works in terms of surveillance (in cows as well as humans), but IDK how much authority @CDCgov has at dairy farms.

@USDA @USDA_APHIS aren't recommending testing for asymptomatic cows and >>

#H5N1 #HPAI #AvianFlu
2/
Apr 20 • 5 tweets • 3 min read
Promising news: per @nmpf's CSO, research is underway from @US_FDA & @USDA
to eval impact of pasteurization (& other processes) on #H5N1 #HPAI in milk:
(Thx @Alexander_Tin)

cc: @RickABright @HelenBranswell @thijskuiken @MarionKoopmans @KrutikaKuppalli
#AvianFlu
1/ Some more details here also on the clinical course of #H5N1 #HPAI in dairy cattle & timeline on farms:



cc: @RickABright @HelenBranswell @thijskuiken @MarionKoopmans @KrutikaKuppalli @EckerleIsabella
#AvianFlu
2/ tinalexander.github.io/notes/2024/04#…


Image
Image
Image
Aug 21, 2022 • 5 tweets • 7 min read
@nicolamlow @angie_rasmussen Yup, the @PIDJournal report on the 2 cases exported to the UK is *much* more informative than that mess in @LancetRespirMed.

NOTE though, there have already been multiple reports from India that "tomato flu" is #HFMD (that the Lancet authors basically ignored) >>

1/ @nicolamlow @angie_rasmussen @PIDJournal @LancetRespirMed Health alerts in May from the districts in Kerala that were 1st affected already stated the colloquially termed "tomato flu" is #HFMD

thehindu.com/news/national/…

2/
Feb 14, 2020 • 9 tweets • 22 min read
14FEB (via @ChannelNewsAsia)
Singapore confirms 9 new #COVID19 cases, bringing the total to 67.

• 6 of the new cases are linked to the Grace of God Church cluster.

@KrutikaKuppalli @HelenBranswell @ScottGottliebMD @UNMC_DrKhan @MackayIM @V2019N



1/ @ChannelNewsAsia @KrutikaKuppalli @HelenBranswell @ScottGottliebMD @UNMC_DrKhan @MackayIM @V2019N 14FEB contd
• Grace of God Church cluster now has 13 cases

• Unclear if the other 3 new #COVID19 cases have known links to travel/transmission chain.
(Awaiting @sporeMOH report.)

• 6 (-1) cases remain in critical care/ICU

• 2 discharges (total recovered cases = 17)

2/